Inhibition by chlorophyllin of 2-amino-3-methylimidazo-[4,5-f] quinoline-induced tumorigenesis in the male F344 rat

Heterocyclic Aromatic Amines Heterocomplexation with Biologically Active Aromatic Compounds and Its Possible Role in Chemoprevention

“…Similar protection against PhIP-induced mammary carcinogenesis in F344 rats by CHL was observed by Hirose et al [55]. Studies on the CHL's influence on the carcinogenic activity of IQ in rats revealed that CHL protected against colon, liver, and small intestine cancers [56]. Furthermore, CHL was proven to protect against PhIP-induced aberrant crypt foci (ACF) in F344 rats, decreasing the uptake of a mutagen from the gastrointestinal tract, as concluded from augmented elimination of unmetabolized PhIP in feces in the presence of CHL [57].…”

DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis

“…Whereas the chemopreventive properties of the inhibitors listed in Table III are known from studies in other model systems, the relationship between inhibition of AIA-DNA adducts and inhibition of AIA tumorigenesis has only been established for CHL as the inhibitor and IQ as the carcinogen (242,244,257). Phenethyl isothiocyanate, however, a well known experimental chemopreventive agent with other chemical carcinogens, did not inhibit PhIP-DNA adduct formation in liver and colon of male Swiss Albino mice (258).…”

Role of Radioprotectors in the Inhibition of DNA Damage and Modulation of DNA Repair After Exposure to Gamma-Radiation

“…Recently, it has also been shown to occur naturally in a constituent of traditional Chinese medicine (Chiu et al 2003). It has chemopreventive, antimutagenic and anticarcinogenic properties (Egner et al 2001;Guo et al 1995). Our lab has explored it radioprotective property in various model systems.…”