Inhibition by  -blockade of the ST segment elevation after acute myocardial infarction in man

PELIDES, L. J.; Reid, D S; Thomas, Michael; Shillingford, John

doi:10.1093/cvr/6.3.295

Cited by 142 publications

(27 citation statements)

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“…In these experimental studies, myocardial damage was reduced with agents aimed at decreasing myocardial oxygen consumption (5-9), at increasing coronary flow either directly by reperfusion (10,11) or indirectly by enhancing collateral flow (5,6,12), by enhancinig anaerobic metabolism (13), and by the administration of hyaluronidase (14) and hydrocortisone (15). The application ofthese principles to the therapy of patients with acute myocardial infarction using some of these interventions seems to confirm these experimenital conclusions (4,6,(16)(17)(18)(19)(20)(21).…”

Section: Introductionmentioning

confidence: 67%

“…After dissolving 1 g of venom in 65 ml sodium phosphate buffer, 0.03M, pH 7.4 at 37°C, the sample is applied to a 2.5 x 40-cm column of equilibrated DEAE-cellulose. The nionbound proteins, mostly phospholipase, are washed through at 50 ml/h for [16][17][18] h. A linear salt gradient to 0.5 M NaCl is then begun, and the anticomplementary peak is concentrated and applied to a G-200 column in isotonic saline phosphate buffer, pH 7.4. The final peak is a homogenous band on polyacrylamide electrophoresis (34) (Fig.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Reduction by Cobra Venom Factor of Myocardial Necrosis after Coronary Artery Occlusion

Maroko¹,

Carpenter²,

Chiariello³

et al. 1978

J. Clin. Invest.

247

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Section: Introductionmentioning

confidence: 67%

Section: Methodsmentioning

confidence: 99%

Reduction by Cobra Venom Factor of Myocardial Necrosis after Coronary Artery Occlusion

Maroko¹,

Carpenter²,

Chiariello³

et al. 1978

J. Clin. Invest.

247

View full text Add to dashboard Cite

“…In recent years, several authors have shown, by assessing the degree and extent of ischaemic injury from epicardial electrocardiograms and/or creatinine phosphokinase release, that f-adrenoceptor blocking agents are capable of reducing 'infarct size' in dogs (Maroko, Kjekshus, Sobel, Watanabe, Covell, Ross & Braunwald, 1971) and in man (Pelides, Reid, Thomas & Shillingford, 1972). These beneficial effects of ablockade are thought to be related to a more favourable balance between myocardial oxygen supply and demand in the ischaemic heart.…”

Section: Introductionmentioning

confidence: 99%

Effects of Atenolol on Regional Myocardial Blood Flow and St Segment Elevation in the Canine Myocardium

Berdeaux

Boissier

Giudicelli

1977

British J Pharmacology

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I The effects of atenolol on regional myocardial blood flow (RMBF) and on ST segment elevation were studied both in normal and ischaemic regions of the myocardium in dogs. Some of the experiments were performed with cardiac pacing or after bilateral stellectomy.2 In the absence of cardiac pacing, atenolol (1 mg/kg, i.v.) induced a marked reduction in heart rate and contractile force and a decrease in RMBF, which was of the same magnitude in normal and ischaemic areas. There was no modification in the endo/epi flow ratio. ST segment elevation in ischaemic areas was significantly reduced. 3 Bilateral steliectomy induced similar effects to those of atenolol. Atenolol after bilateral stellectomy exhibited no additional effects. 4 In dogs submitted to cardiac pacing, atenolol no longer decreased RMBF and ST segment elevation. 5 These results demonstrate that with atenolol, there is no correlation between bradycardia and the endo/epi flow ratio while there is one between bradycardia and reduction in ST segment elevation.

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“…Studies with propranolol (e.g. Sommers & Jennings, 1972), oxprenolol (Pelides et al, 1972) and practolol and timolol (Libby et al, 1973) have all shown a decrease in ischaemic injury in dogs associated with a decrease in oxygen demand of the myocardium.…”

Section: Discussionmentioning

confidence: 99%

Effects of a combination of metoprolol and dazmegrel on myocardial infarct size in rats

Bullock

Leprán

Parratt

et al. 1985

British J Pharmacology

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1 The effects ofacute pretreatment with metoprolol, dazmegrel and a combination of these two drugs has been examined on myocardial infarct size in rats. Ischaemic damage was assessed 4 h after coronary artery occlusion in anaesthetized rats and after 48 h of ischaemia in conscious rats. Infarct size was measured histochemically (by using periodic-acid-Schiff diastase reaction for glycogen) and by standard histological examination (haematoxylin and eosin stain). 2 There was some evidence of protection of the myocardium by metoprolol following 4 h of ischaemia (determined histologically) but this was not apparent 48 h after occlusion. 3 When given alone, dazmegrel had no significant effects on infarct size assessed by either method. A clear reduction in the extent of glycogen depletion and histological damage was observed with the combination of metoprolol and dazmegrel 48 h after the onset of ischaemia. This protection was seen to occur in the horizontal plane of the heart, preventing the extension of the infarct towards the posterior wall of the left ventricle and showing some salvage of the epicardial surfaces.

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Inhibition by -blockade of the ST segment elevation after acute myocardial infarction in man

Cited by 142 publications

References 0 publications

Reduction by Cobra Venom Factor of Myocardial Necrosis after Coronary Artery Occlusion

Reduction by Cobra Venom Factor of Myocardial Necrosis after Coronary Artery Occlusion

Effects of Atenolol on Regional Myocardial Blood Flow and St Segment Elevation in the Canine Myocardium

Effects of a combination of metoprolol and dazmegrel on myocardial infarct size in rats

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