Inhibition by Aspirin and Indomethacin of Uterine Hypertrophy Induced by an Iud

Chaudhuri, Gautam

doi:10.1530/jrf.0.0430077

Cited by 8 publications

(1 citation statement)

References 12 publications

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“…Greenwald (1965) observed an increase in leucocytic response inside the IUD-bearing horn of rats treated with phenylbutazone or cortisone acetate. The uterine hypertrophy provoked by an IUD was not prevented by hydrocortisone (Parr & Segal, 1966;Chaudhuri, 1975) but was reduced by aspirin treatment (Chaudhuri, 1975). We confirm our earlier results (Testart & Fresno-Chavez, 1971) and suggest that drugs commonly used in women may limit the effectiveness of an IUD and thus explain certain failures of this contraceptive method.…”

Section: Discussionsupporting

confidence: 85%

The action of anti-inflammatory drugs on the fertility of female rats with intrauterine contraceptive devices

Testart¹,

Gauthier²

1981

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A silk thread (0-0) or a copper wire (0.18 mm diameter) was placed in the left uterine horn of rats, at least 3 days before fertilization. The animals were untreated or given daily injections of 3 mgh hydrocortisone or 30 mg aspirin beginning the day after insertion of the IUD; 2 weeks after coitus, the animals were killed. A longitudinal (less than or equal to 10 mm) silk thread and the copper wire were effective IUDs regardless of treatment. With the short silk thread (less than or equal to 2 mm), implantation occurred in all groups of rats but a high failure rate was observed in hydrocortisone-treated rats (5/9 with implantations). The no. of implantations/no. of corpora lutea (x 100) was much higher (20.4%) in rats treated with aspirin and hydrocortisone than in untreated animals (3.2%) (P less than 0.01). We conclude that the effectiveness of an IUD can be altered by treatment with an anti-inflammatory substance.

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