Inhibition by antiarrhythmic and ?-sympatholytic drugs of serotonin uptake by human platelets: Experimentsin vitro andin vivo

Grobecker, H.; Hellenbrecht, D.; Wiethold, G.

doi:10.1007/bf00564894

Cited by 28 publications

(10 citation statements)

References 17 publications

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“…15 A further argument pointing in this direction is the recent demonstration that d,I propranolol as the sole beta blocking agents studied so far is a potent serotonin uptake inhibitor. 16 We do not have any information as to how atenolol behaves in this respect.…”

Section: Discussionmentioning

confidence: 99%

Comparative Trial of Tenormin (Atenolol) and Inderal (Propranolol) in Migraine

Stensrud¹,

Sjaastad²

1980

Headache

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SYNOPSIS Atenolol, 50 mg, b.i.d., and propranolol, 80 mg b.i.d., were given to 28 patients with a presumed diagnosis of migraine, in a placebo‐controlled double‐blind cross‐over study, where each period lasted 6 weeks. In the total material, atenolol was significantly better than placebo in reducing attacks, whereas propranolol showed no definite such effect. In seven patients, the number of headache days was remarkably high (average: 22 headache days in 42 days), which may indicate that they have been inappropriately included in the material or have recorded interparoxysmal headache in addition to attacks. If these patients are excluded, the attack‐reducing effects of both propranolol and atenolol are significant and of equal magnitude.

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Section: Discussionmentioning

confidence: 99%

Comparative Trial of Tenormin (Atenolol) and Inderal (Propranolol) in Migraine

Stensrud¹,

Sjaastad²

1980

Headache

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“…As far as beta-blockers potentiated the effect of histamine in shock [3] the findings that some of these drugs inhibited the histamine release from isolated rat mast cells are of great interest [11,18]. The non-specific activity of beta-blockers was related to the high membrane affinity of these drugs [8,9,14].…”

Section: Introductionmentioning

confidence: 99%

The effect of beta-adrenergic blocking drugs and inhibitors of phosphodiesterase on histamine release from isolated mast cells

Nosáľ

Menyhardtová

1977

Agents and Actions

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Differences in the histamine liberation from isolated rat mast cells after beta-adrenergic blocking drugs were demonstrated. In equimolar concentrations histamine release was induced by Kö 1124, Kö 1500, Kö 1560, Kö 1561 and propranolol. Alprenolol, oxprenolol, propranolol, and trimepranol significantly decreased thehistamine release induced by compound 48-80. The release of granules from cells was inhibited quantitatively more than the release of histamine. This enabled us to surmise the selective effect of beta-adrenergic blocking drugs on cell membranes of mast cells. The possible mechanisms of release reaction are discussed.

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“…Oral administration of propranolol (3 mg/kg) reduced the 5-HT uptake into platelets by 50% in human expts. (Grobecker et al 1973). Similar concentrations of propranolol are probably reached after 2 mg i.v.…”

Section: Discussionmentioning

confidence: 82%

The effect of propranolol on the serotonin concentration in the portal plasma after vagal nerve stimulation in the cat

Pettersson

Ahlman

Bhargava

et al. 1979

Acta Physiologica Scandinavica

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Efferent cervical vagal nerve stimulation in the cat caused a marked increase of the portal plasma 5-HT concentration. This increase was more than two-fold within 15 min of stimulation. After cessation of stimulation portal plasma 5-HT returned to basal levels within 10 min. Treatment with the beta-adrenoceptor antagonist propranolol, in various doses (0.1-2 mg/kg b.wt.), did not abolish but significantly reduced the response to vagal stimulation, particularly during the final part of the stimulation period. The results confirm the existence of a beta-adrenoceptor-mediated release of 5-HT, but also suggest that other mechanisms for 5-HT release may be involved in the response on vagal nerve stimulation.

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Inhibition by antiarrhythmic and ?-sympatholytic drugs of serotonin uptake by human platelets: Experimentsin vitro andin vivo

Cited by 28 publications

References 17 publications

Comparative Trial of Tenormin (Atenolol) and Inderal (Propranolol) in Migraine

Comparative Trial of Tenormin (Atenolol) and Inderal (Propranolol) in Migraine

The effect of beta-adrenergic blocking drugs and inhibitors of phosphodiesterase on histamine release from isolated mast cells

The effect of propranolol on the serotonin concentration in the portal plasma after vagal nerve stimulation in the cat

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