Inhibition and the right inferior frontal cortex

Aron, Adam R.; Robbins, Trevor W.; Poldrack, Russell A.

doi:10.1016/j.tics.2004.02.010

Cited by 2,643 publications

(2,146 citation statements)

References 77 publications

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“…In healthy control subjects, functional magnetic resonance imaging (fMRI) studies of response inhibition consistently demonstrate the underlying neurobiology to involve activation of the frontalstriatal circuit (Rubia et al, 2001;Aron et al, 2004;Simmonds et al, 2008). The prefrontal cortex (PFC), which includes the dorsolateral prefrontal cortex (DLPFC), orbital frontal cortex (OFC) and the inferior frontal cortex (IFC), plays a central role in executive functioning through its influence on subcortical and posterior cortical regions via extensive anatomical connections to these areas (Croxson et al, 2005;Leh et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Penfold¹,

Vizueta²,

Townsend³

et al. 2015

Psychiatry Research: Neuroimaging

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Section: Introductionmentioning

confidence: 99%

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Penfold¹,

Vizueta²,

Townsend³

et al. 2015

Psychiatry Research: Neuroimaging

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“…The prefrontal cortex (PFC) is essential for cognitive functions such as working memory (Baddeley, 2003;Bodner et al, 2005;Funahashi et al, 1989Funahashi et al, , 1993Fuster, 2003;Goldman-Rakic, 1995;Miller and Cohen, 2001), attention regulation (Dias et al, 1996;Luria, 1966) and response inhibition (Aron et al, 2004;Luria, 1966). Animals or humans with lesions to the PFC exhibit disorganized behaviors like poor working memory, distractibility, impulsivity and hyperactivity (Fuster, 1997;Luria, 1966).…”

Section: Introductionmentioning

confidence: 99%

Stimulation of α2-Adrenoceptors Suppresses Excitatory Synaptic Transmission in the Medial Prefrontal Cortex of Rat

Zhang

et al. 2007

Neuropsychopharmacol

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Stimulation of a 2 -, especially a 2A -adrenoceptor (AR), in the prefrontal cortex (PFC) produces a beneficial effect on cognitive functions such as working memory. a 2 -Adrenergic agonists like clonidine and guanfacine have been used experimentally and clinically for treatment of psychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and schizophrenia. However, the neurophysiological actions of a 2 -ARs in the PFC are poorly understood. In the present study, we recorded field excitatory post-synaptic potential (fEPSP) and evoked excitatory post-synaptic current (eEPSC) in the medial prefrontal cortex (mPFC) of rats, using in vivo field-potential recording and in vitro whole-cell patch-clamp recording techniques, and examined the effects of the a 2 -AR agonist clonidine and the selective a 2A -AR agonist guanfacine on fEPSP and eEPSC. Systemic or intra-mPFC application of clonidine or guanfacine significantly reduced fEPSP in the mPFC, either in anesthetized or freely moving rats. Consistently, bath-application of guanfacine suppressed eEPSC in layer V/VI pyramidal neurons, and this effect was blocked by the a 2 -AR antagonist yohimbine or the G i inhibitor NF023. Moreover, treatment with guanfacine had no effect on paired-pulse facilitation (PPF) of fEPSP and eEPSC. The present study provides the first electrophysiological evidence that stimulation of a 2A -AR inhibits excitatory synaptic transmission in the mPFC through a post-synaptic mechanism.

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“…Furthermore, several studies have found laterality differences in brain activity during response inhibition between children and adults. While response inhibition in adults is typically associated with greater activity in the right hemisphere (Aron, Robbins, & Poldrack, 2004), several studies have found that children display greater activity in the left hemisphere (Bunge, Dudukovic, Thomason, Vaidya, & Gabrieli, 2002; Johnstone, Pleffer, Barry, Clarke, & Smith, 2005). In addition to the studies highlighted above, Hoyniak (2017) recently performed a meta-analysis of 65 studies that have utilized the GNG task to assess inhibition in children aged 2 to 12 years old.…”

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confidence: 99%

Neural Correlates of Response Inhibition in Early Childhood: Evidence From a Go/No-Go Task

Rahman

Carroll

Espy

et al. 2017

Developmental Neuropsychology

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We examined the neural correlates underlying response inhibition in early childhood. Five-year-old children completed a Go/No-go task with or without time pressure (Fast vs. Slow condition) while scalp EEG was recorded. On No-go trials where inhibition was required, the left frontal N2 and posterior P3 were enhanced relative to Go trials. Time pressure was detrimental to behavioral performance and modulated the early-occurring P1 component. The topography of ERPs related to response inhibition differed from patterns typically seen in adults, and may indicate a compensatory mechanism to make up for immature inhibition networks in children.

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Inhibition and the right inferior frontal cortex

Cited by 2,643 publications

References 77 publications

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Stimulation of α2-Adrenoceptors Suppresses Excitatory Synaptic Transmission in the Medial Prefrontal Cortex of Rat

Neural Correlates of Response Inhibition in Early Childhood: Evidence From a Go/No-Go Task

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