Inhibition and excitation of thoracic spinoreticular neurons by electrical stimulation of vagal afferent nerves

Thies, Roger; Foreman, Robert D.

doi:10.1016/0014-4886(83)90238-8

Cited by 37 publications

(10 citation statements)

References 26 publications

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“…In the cat model, an inhibition of sham rage in decerebrated animals was described 17 . Later experiments that characterized the consequences of electrical stimulation of vagal afferents for somatosensory functions underlined the role of the vagal nerve for endogenous pain modulation 18,19 …”

Section: Discussionmentioning

confidence: 99%

“…17 Later experiments that characterized the consequences of electrical stimulation of vagal afferents for somatosensory functions underlined the role of the vagal nerve for endogenous pain modulation. 18,19 Interestingly, stimulation of vagal afferents can not only lead to inhibition of nociception but also to facilitation. Ren et al 20 have described such a biphasic response of spinal nociceptive transmission following electrical stimulation of cervical vagal afferents depending on the intensity of stimulation.…”

Section: Discussionmentioning

confidence: 99%

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Subdiaphragmatic vagal afferent innervation in activation of an opioidergic antinociceptive system in response to colorectal distension in rats

Gschossmann¹,

Mayer²,

Miller³

et al. 2002

Neurogastroenterology Motil

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In a number of different experimental paradigms of somatic pain, there is evidence for a vagally mediated antinociceptive system. This pathway probably involves opioid mechanisms. However, whether this pathway is activated in visceral pain or if it involves subdiaphragmatic vagal afferents is unclear. The aim of the present study was to determine whether subdiaphragmatic vagal afferents mediate antinociception in response to a visceral stimulus and whether this involves an opioid pathway. Colorectal distension was performed in fasted, conscious male Sprague-Dawley rats using a balloon catheter connected to an electronic distension device. The number of abdominal contractions (visceromotor response) in response to a tonic colorectal distension (60 mmHg for 10 min) was recorded. Experiments were performed in sham or subdiaphragmatically vagotomized, perineural vehicle- or capsaicin-treated rats (to functionally denervate vagal afferents) before and after administration of naloxone (25 mg kg(-1) bodyweight intraperitoneally). Vagotomy, capsaicin and naloxone pretreatments all significantly enhanced the visceromotor response to colorectal distension. The effect of naloxone in capsaicin-treated rats did not appear to be additive. These results suggest that activation of subdiaphragmatic afferents, which can be blocked by capsaicin, may play a role in opioid-dependent antinociceptive pathways activated by a noxious visceral stimulus.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Subdiaphragmatic vagal afferent innervation in activation of an opioidergic antinociceptive system in response to colorectal distension in rats

Gschossmann¹,

Mayer²,

Miller³

et al. 2002

Neurogastroenterology Motil

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“…Several neurophysiological studies reported that VNS had predominantly inhibitory effect on activity of lumbar and thoracic spinal neurons (Thies and Foreman, 1983;Hobbs et al, 1989;Ren et al, 1991;Evans et al, 1994). In addition, the vagal afferent stimulation has been found to suppress the spike frequency and c-fos expression occurring in trigeminal and trigeminothalamic neurons in response to noxious orofacial stimulation (Bossut and Maixner, 1996;Bohotin et al, 2003b).…”

Section: Introductionmentioning

confidence: 98%

Vagal afferent modulation of spinal trigeminal neuronal responses to dural electrical stimulation in rats

2012

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“…The baroreceptor-reflex mechanism may therefore be inadequate to account for this phenomenal non-response in the HF component of HRV to time-related BP increases. In Mechanism III, Kirchner et al (2000) have found that vagus nerve stimulation attenuates pain, while Thies and Foreman (1983) and Chandler et al (1991) have reported that stimulation of cervical, thoracic and cardiac vagal afferents suppresses secondary nociceptive neuronal activities via the spinothalamic and spinoreticular tracts of the nociceptive ascending spinal pathways. These findings suggest that vagus nerve stimulation is associated with pain suppression.…”

Section: Activation Of Vagus Nerve Activity To Suppress Dysmenorrhea-mentioning

confidence: 99%

Specific Physiological Responses in Women with Severe Primary Dysmenorrhea during the Menstrual Cycle

Park

Watanuki

2005

J. Physiol. Anthropol.

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This study examined the specific physiological responses of women with primary dysmenorrhea during the severely painful menstrual (days 1-2 of menstruation) and the non-painful follicular phases (days 5-8 after the onset of menstruation). Subjects consisted of 10 severe primary dysmenorrheic (Group P) and 10 non-dysmenorrheic women (Group C) with regular menstrual cycles. However, only 9 out of 10 and 8 out of 10 subjects of Groups P and C participated during the follicular phase. Physiological measures were taken in a resting state for 60 min. In the menstrual phase, the pain ratings and secretory immunoglobulin A (s-IgA) concentrations of Group P were significantly higher than those of Group C, with relatively significant decreases in the leg-skin temperature in the former as well. In addition, the systolic (SBP) and diastolic blood pressure (DBP) at 45 min after rest in Group P were significantly higher than those found in Group C. These reactions strongly suggest activation of the sympathetic-adrenal-medullary axis (SAM axis) by painful stress. Furthermore, the low-frequency (LF) component of the SBP variability (SBPV) was significantly higher in Group P than Group C, even during the follicular phase. These findings imply that Group P may well have elevated activities of the SAM axis throughout the whole menstrual cycle. As such, it suggests that dysmenorrheic women may be affected by certain stressors other than pain per se and pain-derived emotions throughout the whole menstrual cycle. The findings also indicate that women with dysmenorrhea have more sensitive responses to the SAM system than non-dysmenorrheic women during stress. Moreover, the high-frequency (HF) component of heart rate variability (HRV), or the index for the vagus nerve activity, displayed a consistently higher value in Group P than C. It is postulated that the human body may have responded to pain in an attempt to maintain the homeostatic state by enhancing vagus nerve activity.

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Inhibition and excitation of thoracic spinoreticular neurons by electrical stimulation of vagal afferent nerves

Cited by 37 publications

References 26 publications

Subdiaphragmatic vagal afferent innervation in activation of an opioidergic antinociceptive system in response to colorectal distension in rats

Subdiaphragmatic vagal afferent innervation in activation of an opioidergic antinociceptive system in response to colorectal distension in rats

Vagal afferent modulation of spinal trigeminal neuronal responses to dural electrical stimulation in rats

Specific Physiological Responses in Women with Severe Primary Dysmenorrhea during the Menstrual Cycle

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