Inhibition activities of<i>colchicum luteum</i>baker on lipoxygenase and other enzymes

Ahmad, Bashir; Khan, Haroon; Bashir, Shumaila; Nisar, Muhammad; Hassan, Mukhtiar

doi:10.1080/14756360600586148

Cited by 19 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Keeping in mind its uses as folk medicine, though deserved, this plant has not been extensively subjected to phytochemical and pharmacological investigation. The present study is the continuation of our previous work [22,23].…”

Section: Plant Backgroundsupporting

confidence: 69%

Antibacterial and antifungal activities of teucrium royleanum (Labiatea)

Ahmad¹,

Shah

Bashir

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

Self Cite

View full text Add to dashboard Cite

The crude methanolic extract and subsequent fractions of Teucrium royleanum (Labiatea) were screened for antibacterial and antifungal activities. Against tested pathogens, crude extract and subsequent fractions demonstrated moderate to excellent antibacterial activities. Highest antibacterial activity was displayed by the ethyl acetate fraction against S. typhi (100%), against E.coli (76.7%) and against P. aerugenosa (70.8%) followed by the chloroform fraction against S. typhi (85.7%). Similarly, the crude extract and its subsequent fractions showed mild to excellent activities in the antifungal bioassay with maximum antifungal activity against M. canis (87%) by the chloroform fraction followed by the ethyl acetate (71%) and n-butanol (70%) fractions.

show abstract

Section: Plant Backgroundsupporting

confidence: 69%

Antibacterial and antifungal activities of teucrium royleanum (Labiatea)

Ahmad¹,

Shah

Bashir

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…luteum Baker, an annual herb which is widely distributed in the Western Himalayas, has been used by practitioners of traditional medicine for the treatment of gout, diseases of liver and spleen, rheumatoid arthritis, and other inflammatory and granulomatous disorders [18,19]. CL methanolic extract has been demonstrated to possess potent lipoxygenase inhibitory activity in experimental studies [20]. Additionally, the principal alkaloid of CL, colchicine, has been demonstrated to prevent polymerization of microtubules in proinflammatory cells and thus inhibit their chemotaxis [6].…”

Section: Discussionmentioning

confidence: 99%

Investigation into the Anti-inflammatory and Antigranuloma Activity of Colchicum luteum Baker in Experimental Models

et al. 2011

View full text Add to dashboard Cite

The present study evaluates the anti-inflammatory and antigranuloma activity of CLHE in experimental models, viz. carrageenan-induced paw edema, subcutaneous cotton pellet implantation-induced granuloma formation, and complete Freund's adjuvant-induced stimulation of peritoneal macrophages in rats. Serum TNF-alpha, IL-6, and IL-1 beta levels were estimated as markers for global effects of inflammation. TNF-R1 protein expression was estimated in stimulated peritoneal macrophages. There was a significant reduction (P < 0.05) of paw edema in the CLHE-treated groups as compared to control. In the cotton pellet-induced granuloma model, there was a significant (P < 0.05) reduction in the dry granuloma weight and serum TNF-alpha, IL-6, and IL-1beta levels in the CLHE-treated group as compared to control. Immunoblot analysis for TNF-R1 also demonstrated a significant reduction in the receptor protein expression on stimulated macrophages. Result of the present study thus demonstrates and validates the antigranuloma activity of CLHE.

show abstract

“…Despite its wide spread use in traditional medicine for treatment of gout and rheumatism, only a few studies have evaluated the efficacy of this medicinal plant in experimental and clinical settings. The methanolic extract of this plant has been shown to possess potent lipoxygenase inhibitory activity in in-vitro experiments (Ahmad et al, 2006). A few clinical studies in alternative medicine have reported symptomatic improvement in patients with RA after the use of polyherbal formulations containing CL extract (Joshi et al, 1973;Javed et al, 2005).…”

Section: Introductionmentioning

confidence: 99%