Inhibiting the posterior medial prefrontal cortex by rTMS decreases the discrepancy between self and other in Theory of Mind reasoning

Schuwerk, Tobias; Schecklmann, Martin; Langguth, Berthold; Döhnel, Katrin; Sodian, Beate; Sommer, Monika

doi:10.1016/j.bbr.2014.08.031

Cited by 34 publications

(28 citation statements)

References 57 publications

(69 reference statements)

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“…Furthermore, dementia affecting medial frontal cortex impairs performance on a series of false belief and mentalizing tasks (Modinos et al, 2009). Inhibiting the medial BA 8 by applying low-frequency repetitive TMS significantly impairs participants' ability to distinguish between one's perspective and another's perspective in a false belief task (Schuwerk et al, 2014b). (Krause et al, 2012) also delivered low-frequency deep repetitive TMS to bilateral medial BA 8 and investigated performance on a task in which mental states are inferred based on eye gaze and facial expression.…”

Section: Dorsomedial Frontal Cortexmentioning

confidence: 99%

Perceiving emotional expressions in others: Activation likelihood estimation meta-analyses of explicit evaluation, passive perception and incidental perception of emotions

Dricu

Frühholz

2016

Neuroscience & Biobehavioral Reviews

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We conducted a series of activation likelihood estimation (ALE) meta-analyses to determine the commonalities and distinctions between separate levels of emotion perception, namely incidental perception, passive perception, and explicit evaluation of emotional expressions. Pooling together more than 180 neuroimaging experiments using facial, vocal or body expressions, our results are threefold. First, explicitly evaluating the emotions of others recruits brain regions associated with the sensory processing of expressions, such as the inferior occipital gyrus, middle fusiform gyrus and the superior temporal gyrus, and brain regions involved in low-level and high-level mindreading, namely the posterior superior temporal sulcus, the inferior frontal cortex and dorsomedial frontal cortex. Second, we show that only the sensory regions were also consistently active during the passive perception of emotional expressions. Third, we show that the brain regions involved in mindreading were active during the explicit evaluation of both facial and vocal expressions. We discuss these results in light of the existing literature and conclude by proposing a cognitive model for perceiving and evaluating the emotions of others.

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Section: Dorsomedial Frontal Cortexmentioning

confidence: 99%

Perceiving emotional expressions in others: Activation likelihood estimation meta-analyses of explicit evaluation, passive perception and incidental perception of emotions

Dricu

Frühholz

2016

Neuroscience & Biobehavioral Reviews

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“…The inhibition of the posterior medial prefrontal cortex (pMPFC) by 1 Hz dmPFC stimulation and its effects on theory of mind (TOM) reasoning has been investigated in 17 healthy students. The discrepancy in reaction times between judging another's and one's own belief was decreased by one single session of 2000 pulses of dmPFC‐DCC–stimulation at 1 Hz . This result was interpreted as support for pMPFC's causal role in establishing perspective differences.…”

Section: Resultsmentioning

confidence: 79%

A Comprehensive Review of Dorsomedial Prefrontal Cortex rTMS Utilizing a Double Cone Coil

Kreuzer

Downar

Ridder

et al. 2019

Neuromodulation: Technology at the Neural Interface

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“…The participants received repeated stimulation at 1 and 10 Hz in two randomized sessions with a 1week intersession interval. The purpose of the 1-week wash-out period was to avoid carry over effects (e.g., Schuwerk et al, 2014). Each rTMS session consisted of 2000 pulses.…”

Section: Rtms Administrationmentioning

confidence: 99%

Testing the role of the posterior cingulate cortex in processing salient stimuli in cannabis users: an rTMS study

Prashad

Dedrick

et al. 2018

Eur J of Neuroscience

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The posterior cingulate cortex (PCC) and precuneus are hubs in the default mode network and play a role in processing external salient stimuli. Accordingly, activation in these regions has been associated with response to salient stimuli using drug cue‐reactivity paradigms in substance using populations. These studies suggest that the PCC and precuneus may underlie deficits in processing salient stimuli that contribute toward the development of substance use disorders. The goal of this study was to directly test this hypothesis using repetitive transcranial magnetic stimulation (rTMS). Using a double‐blind, placebo‐controlled design, we used rTMS to target the PCC and precuneus with a double‐cone coil at 10 Hz (high frequency) and 1 Hz (low frequency) in 10 adult cannabis users and 10 age‐ and sex‐matched non‐using controls. Electroencephalography data were collected before and after rTMS during a modified oddball paradigm with neutral, oddball, self‐relevant, and cannabis‐related stimuli. Cannabis users exhibited increased amplitude in P3 and faster latencies in the P3, N2, and P2 components in response to self‐relevant stimuli compared to controls during baseline that normalized after rTMS. These results suggest that cannabis users exhibited heightened salience to external self‐relevant stimuli that were modulated after rTMS. PCC dysfunction in cannabis users may be related to abnormalities in processing salient stimuli, such those during cue‐reactivity, and provides a potential target for cannabis use disorder intervention.

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Inhibiting the posterior medial prefrontal cortex by rTMS decreases the discrepancy between self and other in Theory of Mind reasoning

Cited by 34 publications

References 57 publications

Perceiving emotional expressions in others: Activation likelihood estimation meta-analyses of explicit evaluation, passive perception and incidental perception of emotions

Perceiving emotional expressions in others: Activation likelihood estimation meta-analyses of explicit evaluation, passive perception and incidental perception of emotions

A Comprehensive Review of Dorsomedial Prefrontal Cortex rTMS Utilizing a Double Cone Coil

Testing the role of the posterior cingulate cortex in processing salient stimuli in cannabis users: an rTMS study

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