Inhibiting the CB1 receptor in CIH-induced animal model alleviates colon injury
Pei-Pei Wang,
Xiao-Qian Cheng,
Zhan-Jun Dou
et al.
Abstract:Obstructive sleep apnea (OSA) can lead to intestinal injury, endotoxemia, and disturbance of intestinal flora. Additionally, as a crucial component of the endocannabinoid system, some studies have demonstrated that cannabinoid 1 (CB1) receptors are closely linked to the multiple organ dysfunction triggered by OSA. However, the role of the CB1 receptor in alleviating OSA-induced colon injury remains unclear. Here, through the construction of the OSA classic model, we found that the colon tissue of chronic inte… Show more
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