2016
DOI: 10.1016/j.bbrc.2016.07.049
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Inhibiting PPARγ by erythropoietin while upregulating TAZ by IGF1 synergistically promote osteogenic differentiation of mesenchymal stem cells

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Cited by 15 publications
(14 citation statements)
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“…As reported, TAZ binds strongly to the Pro‐Pro‐ X‐Tyr motif found within regulatory regions of RUNX2 and PPARγ . It interacted with RUNX2 and co‐activates RUNX2‐dependent gene transcription, while interacting with PPARγ and repressing its downstream target gene expression . Consistently, our results suggested that Sal B at least partially targeted TAZ to regulate the cells differentiation into osteoblasts or adipocytes.…”
Section: Discussionsupporting
confidence: 89%
See 1 more Smart Citation
“…As reported, TAZ binds strongly to the Pro‐Pro‐ X‐Tyr motif found within regulatory regions of RUNX2 and PPARγ . It interacted with RUNX2 and co‐activates RUNX2‐dependent gene transcription, while interacting with PPARγ and repressing its downstream target gene expression . Consistently, our results suggested that Sal B at least partially targeted TAZ to regulate the cells differentiation into osteoblasts or adipocytes.…”
Section: Discussionsupporting
confidence: 89%
“…TAZ, a transcriptional modulator, could interact with kinds of transcription factors to influence the stem cells fate determination . As reported, TAZ binds strongly to the Pro‐Pro‐ X‐Tyr motif found within regulatory regions of RUNX2 and PPARγ . It interacted with RUNX2 and co‐activates RUNX2‐dependent gene transcription, while interacting with PPARγ and repressing its downstream target gene expression .…”
Section: Discussionmentioning
confidence: 86%
“…Given insulin/IGF-I's role in mesenchymal stem cell (MSC) osteogenesis [22,23,[28][29][30], we hypothesized that insulin promotes proliferation and in vitro osteogenic differentiation of TPCs. Our results indicate that insulin significantly increased TPC proliferation after 3 days of monolayer culture.…”
Section: Discussionmentioning
confidence: 99%
“…Using SEM, we showed that cells in the scaffold attached around the pores, and we highlighted the good morphology and viability of BMMSCs grown under these conditions. Finally, we used ALP-a commonly assessed marker of osteogenesis-to confirm the osteogenic potential of BMMSCs on the scaffolds 29) . We found significantly elevated ALP activity in cells growing on the BMP-6-containing CCM scaffolds.…”
Section: Discussionmentioning
confidence: 99%