Inhibiting mast cell degranulation by HO-1 affects dendritic cell maturation in vitro

Ma, Yuanyuan; Yang, Minwei; Wang, Chunfeng; Ding, Jing; Li, Jiyu

doi:10.1007/s00011-014-0722-8

Cited by 15 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Induction of HO-1 expression in MCs suppressed their degranulation and production of inflammatory cytokines ( Takamiya et al, 2002 ; Yasui et al, 2007 ; Pae et al, 2008 ; Matsushima et al, 2009 ). Furthermore, HO-1-expressing murine MCs restrained dendritic cell (DC) maturation in vitro followed by a decreased capacity of the DCs to provoke proliferation of spleen mononuclear cells ( Ma et al, 2014 ).…”

Section: Effects Of Ho-1 On Mast Cellsmentioning

confidence: 99%

Effects of heme oxygenase-1 on innate and adaptive immune responses promoting pregnancy success and allograft tolerance

Schumacher

Zenclussen

2015

Front. Pharmacol.

View full text Add to dashboard Cite

The heme-degrading enzyme heme oxygenase-1 (HO-1) has cytoprotective, antioxidant, and anti-inflammatory properties. Moreover, HO-1 is reportedly involved in suppressing destructive immune responses associated with inflammation, autoimmune diseases, and allograft rejection. During pregnancy, maternal tolerance to foreign fetal antigens is a prerequisite for successful embryo implantation and fetal development. Here, HO-1 has been implicated in counteracting the overwhelming inflammatory immune responses towards fetal allo-antigens, thereby contributing to fetal acceptance. Accordingly, HO-1 ablation negatively impacts the critical steps of pregnancy such as fertilization, implantation, placentation, and fetal growth. In the present review, we summarize recent data on the immune modulatory capacity of HO-1 towards allo-antigens expressed by the semi-allogeneic fetus and organ allografts. In this regard, HO-1 has been shown to promote alloantigen tolerance by blocking dendritic cell maturation resulting in reduced T cell responses and increased numbers of regulatory T cells. Moreover, HO-1 is suggested to shift the uterine cytokine milieu towards a protective Th2 profile and protects fetal tissue from apoptosis by upregulating anti-apoptotic molecules. Thus, HO-1 is not only a pivotal regulator of the initial steps of pregnancy; but also, an important player in supporting the maternal immune system in tolerating the fetus.

show abstract

Section: Effects Of Ho-1 On Mast Cellsmentioning

confidence: 99%

Effects of heme oxygenase-1 on innate and adaptive immune responses promoting pregnancy success and allograft tolerance

Schumacher

Zenclussen

2015

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Previous studies have demonstrated that hemin regulates the function of various immune cells, such as nature kill cells, neutrophils, dendritic cells, and different subtypes of T cells. [32][33][34][35] Therefore, except for macrophage, multiple targets may contribute to therapeutic effects of hemin in CGR.…”

Section: Discussionmentioning

confidence: 99%

Hemin Promotes Corneal Allograft Survival Through the Suppression of Macrophage Recruitment and Activation

Dai

Cheng

et al. 2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…These cells function in the innate (27) and adaptive immune system (28). MCs may release cytokines that influence the diseased state, and inhibition of MC degranulation by HO-1 disrupted DC maturation in vitro (29). This indicates that for MCs to perform their function in the adaptive immune system, DC maturation and migration may be required.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of heme oxygenase-1 in Kupffer cells blocks mast cell degranulation and inhibits dendritic cell migration in vitro

Yang

et al. 2017

Molecular Medicine Reports

Self Cite

View full text Add to dashboard Cite

Kupffer cells (KCs) influence liver allografts by interacting with other non‑parenchymal cells. However, the exact mechanism remains unclear. Upregulation of heme oxygenase-1 (HO-1) in KCs upon interaction with mast cells (MCs), and the effects on dendritic cell (DC) function, were investigated in the present study. KCs, MCs and DCs were prepared from 8‑10‑week‑old C57BL/6 mice. KCs were pretreated with PBS, dimethyl sulfoxide, hemin (50 µM; HO‑1 inducer), and zinc protoporphyrin (50 µM; HO‑1 inhibitor) for 8 h. Reverse transcription‑polymerase chain reaction and western blotting was performed to determine HO‑1 mRNA and protein levels in KCs, respectively. C‑C motif chemokine receptor 7 (CCR7) surface molecules were measured using flow cytometry, and prostaglandin E2 (PGE2), C‑C motif chemokine ligand (CCL) 19 and CCL21 were measured by ELISA. The Transwell model was used to investigate the migration of DCs. Pretreatment of KCs with hemin induced HO‑1 transcription and protein expression, and interacted with and stabilized MC membranes. When co‑cultured with MCs, the expression of CCR7 on DCs was reduced, and PGE2, CCL19 and CCL21 were similarly decreased. DC migration was also impaired. Upregulation of HO‑1 in KCs blocked MC degranulation and reduced DC migration.

show abstract

Inhibiting mast cell degranulation by HO-1 affects dendritic cell maturation in vitro

Abstract: Inhibiting MC degranulation by HO-1 restrained DC maturation and attenuated the proliferation of SMCs.

Cited by 15 publications

References 33 publications

Effects of heme oxygenase-1 on innate and adaptive immune responses promoting pregnancy success and allograft tolerance

Effects of heme oxygenase-1 on innate and adaptive immune responses promoting pregnancy success and allograft tolerance

Hemin Promotes Corneal Allograft Survival Through the Suppression of Macrophage Recruitment and Activation

Upregulation of heme oxygenase-1 in Kupffer cells blocks mast cell degranulation and inhibits dendritic cell migration in vitro

Contact Info

Product

Resources

About