Inhibiting factors produced by lactic acid bacteria. 1. Oxygen metabolites and catabolism end-products

Abstract

To cite this version:Jc Piard, M Desmazeaud. Inhibiting factors produced by lactic acid bacteria. 1. Oxygen metabolites and catabolism end-products. Le Lait, INRA Editions, 1991, 71 (5), pp.525-541. <hal-00929265>Lait (1991) Summary -Lactic acid bacteria can produce a variety of antimicrobial compounds which may affect both the lactic acid bacteria themselves as weil as undesirable or pathogenic strains. In this first section, we describe the biosynthesis, mode of action and activity spectra of these inhibitors. Metabolites of oxygen (hydrogen peroxide and free radicals) exhibit a bacteriostatic or bactericidal activity against lactic or non-Iactic flora. When associated with the lactoperoxidase/thiocyanate system, hydrogen peroxide leads to the formation of inhibitory compounds which are bacteriostatic for lactic acid bacteria and bactericidal for Gram-negative bacteria. The antimicrobial activity of organic acids (Iactic, acetic and formic) and of pH are closely linked. It appears that the non-dissociated fraction of these acids is the major inhibitory form. Thus, acetic acid whose pKa is higher than that of lactic acid exhibits the highest inhibitory activity. The antimicrobial activities of diacetyl, acetaldehyde and of the D isomers of amino acids are also described, although their effects are slight in usual lactic fermentations. 8acteriocins are the last type of inhibitory substance produced by some lactie acid bacteria. They will be described in a second section.lactic acid bacteria / oxygen 1 acidity 1 diacetyll acetaldehyde Résumé -Facteurs inhibiteurs produits par les bactéries lactiques. 1. Métabolites de l'oxygène et produits du catabolisme. Les bactéries lactiques sont capables de produire une variété de produits inhibiteurs dont les effets peuvent se répercuter sur la flore lactique el/e-même mais aussi sur les flores indésirables ou pathogènes. Dans cette première partie, nous décrivons les méca-nismes d'apparition, les modes d'action et les spectres d'activité de ces inhibiteurs. Les métabolites de l'oxygène (le peroxyde d'hydrogène et les radicaux libres) peuvent avoir des effets biologiques de

Effect of anaerobic bovine colostrum fermentation on bacteria growth inhibition

“…Besides this pH action, the lactic acid bacteria have the ability to produce antimicrobial compounds called bacteriocins (BURITI & SAAD, 2007), inhibitory substances, such as hydrogen peroxide, diacetyl, oxygen metabolites, and others (PIARD & DESMAZEAUD, 1991). Many lactic acid bacteria play an important role in the production of fermented foods by inhibiting the growth of a wide variety of food spoiling organisms (JACK et al, 1995).…”

Postnatal morphological development and production of short-chain fatty acids in the digestive tract of gnotobiotic piglets

“…The ability to generate organic acids, particularly lactic and acetic acids, present one of the mechanisms by which lactobacilli perform their inhibitory effect upon pathogens (Piard and Desmazeaud, 1991). With decreasing pH values, the inhibitory activity of the above acids increases (Daly et al, 1972), their molecular form being toxic for bacteria.…”

Propiedades probióticas de Lactobacillus spp aislados de biopsias gástricas de pacientes con y sin infección por Helicobacter pylori

“…Este microorganismo puede ayudar a prevenir o tratar diversas enfermedades gastrointestinales, ya sea, impidiendo la ocupación de sitios específicos, produciendo sustancias antagónicas o modulando la respuesta inmune [18][19][20][21] . Producen metabolitos conocidos como sustancias antagónicas, entre ellos, ácidos grasos de cadena corta (AGCCs) y peróxido de hidrógeno (H 2 O 2 ) 22,23 . Uno de los AGCCs es el ácido láctico, que disminuye el pH impidiendo el desarrollo de diversos microorganismos.…”

“…Entre éstas, señala que Lactobacillus spp puede ejercer efecto bactericida sobre H pylori a través de la liberación de bacteriocinas e inhibir su adherencia a células epiteliales. Se ha demostrado que también presenta efecto anti H pylori inhibiendo su ureasa 22,26,27 o produciendo H 2 O 2 , molécula que induce muerte bacteriana mediante un mecanismo de defensa antimicrobiano inespecífico 15,23 .…”