Inhibiting CSF1R alleviates cerebrovascular white matter disease and cognitive impairment
Katharine E. Askew,
Joshua Beverley,
Emma Sigfridsson
et al.
Abstract:White matter abnormalities, related to poor cerebral perfusion, are a core feature of small vessel cerebrovascular disease, and critical determinants of vascular cognitive impairment and dementia. Despite this importance there is a lack of treatment options. Proliferation of microglia producing an expanded, reactive population and associated neuroinflammatory alterations have been implicated in the onset and progression of cerebrovascular white matter disease, in patients and in animal models, suggesting that … Show more
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