Inhibiting Aβ toxicity in Alzheimer's disease by a pyridine amine derivative

Zhu, Zhenzhu; Yang, Tao; Zhang, Lei; Liu, Lulu; Yin, Enmao; Zhang, Changli; Guo, Zijian; Chen, Xu; Wang, Xiaoyong

doi:10.1016/j.ejmech.2019.02.052

Cited by 32 publications

(11 citation statements)

References 56 publications

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“…The ROS level was reflected by the DCF fluorescence that is positively dependent on the oxidization of DCFH by intracellular ROS. 59 As shown in Fig. 10A , the green fluorescence intensity of BPBA-treated worms is significantly weakened as compared with that of the control, suggesting that BPBA can inhibit the production of ROS in the worms.…”

Section: Resultsmentioning

confidence: 80%

Concurrent suppression of Aβ aggregation and NLRP3 inflammasome activation for treating Alzheimer's disease

et al. 2022

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Section: Resultsmentioning

confidence: 80%

Concurrent suppression of Aβ aggregation and NLRP3 inflammasome activation for treating Alzheimer's disease

et al. 2022

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“…Collected supernatant was boiled with loading buffer at 100°C for 5 min before being loaded into the gel. A 10–180 kDa protein marker (PR1910, Solarbio, China) was used as an indicator of molecular weight ( Zhu et al, 2019 ). Samples were run at 40 V for 40 min on a stacking gel, and at 80 V for 120 min on a separating gel.…”

Section: Methodsmentioning

confidence: 99%

Autophagy Regulation Influences β-Amyloid Toxicity in Transgenic Caenorhabditis elegans

Lin

Gao

Zhang

et al. 2022

Front. Aging Neurosci.

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Alzheimer’s disease (AD) is a progressive, neurodegenerative disease characterized by the accumulation of amyloid-beta (Aβ) proteins in the form of plaques that cause a proteostasis imbalance in the brain. Several studies have identified autophagy deficits in both AD patients and AD animal models. Here, we used transgenic Caenorhabditis elegans to study the relationship between autophagy flux and Aβ. We labeled autophagosomes with an advanced fluorescence reporter system, and used this to observe that human Aβ expression caused autophagosome accumulation in C. elegans muscle. The autophagy-related drugs chloroquine and 3-MA were employed to investigate the relationship between changes in autophagic flux and the toxicity of Aβ expression. We found that reducing autophagosome accumulation delayed Aβ-induced paralysis in the CL4176 strain of C. elegans, and alleviated Aβ-induced toxicity, thus having a neuroprotective effect. Finally, we used RNA-sequencing and proteomics to identify genes whose expression was affected by Aβ aggregation in C. elegans. We identified a series of enriched autophagy-related signal pathways, suggesting that autophagosome accumulation impairs Aβ protein homeostasis in nematodes. Thus, maintaining normal autophagy levels appears to be important in repairing the protein homeostasis imbalance caused by Aβ expression.

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“…[54] Compound 109, is a polydentate Ndonor ligand and was proved very effective AChE inhibitor. [61] The activity was found to be dose dependant, the compound was tested during in vivo and in vitro experiments, on the basis of its performance, it could be lead compound to combat AD (Alzheimer Disease) in future. The enzyme topo-I (Topoisomerase I), is responsible for relaxing the double strand DNA structure and is one of the causes of DNA repair genes deficiency.…”

Section: Enzyme Inhibitionmentioning

confidence: 99%

Pyridine Derivatives as Biologically Active Precursors; Organics and Selected Coordination Complexes

Khan

2021

ChemistrySelect

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Pyridine (py) is an important heterocyclic compound and is an integral part of various natural products. There are various medicines containing py ring system being available in the market to combat different human ailments. Observing the medicine market, Omeprazole, a widely used py-based drug in medicinal market since 1998. Netupitant (an antiemitic drug, since 2014) is used in combination with another drug to prevent acute and delayed vomiting and nausea associated with cancer chemotherapy led the run towards development of anticancer drugs. Several drugs have been approved by FDA for the treatment of cancer in recent years such as, Abemaciclib (2015), Lorlatinib (2018), Apalutamide (2018) and Ivosidenib (2019). Research on py on the bases of these advancements is an evergreen field and associated with greater hopes to address several disease related issues. Several compounds are in the process of clinical trials and are expected to serve various purposes in days to come. This review article deals with recent findings in py chemistry and its coordination complexes. The medicinal efficiency has been argued for organic and inorganic derivatives. Selected biological applications are hereby discussed as follow up study of our report in 2015. Suitable literature prior to 2015 has also been incorporated in appropriate places in order to cover the scope in broader sense.

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Inhibiting Aβ toxicity in Alzheimer's disease by a pyridine amine derivative

Cited by 32 publications

References 56 publications

Concurrent suppression of Aβ aggregation and NLRP3 inflammasome activation for treating Alzheimer's disease

Concurrent suppression of Aβ aggregation and NLRP3 inflammasome activation for treating Alzheimer's disease

Autophagy Regulation Influences β-Amyloid Toxicity in Transgenic Caenorhabditis elegans

Pyridine Derivatives as Biologically Active Precursors; Organics and Selected Coordination Complexes

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