Inhibins in Normal Male Physiology

O’Connor, Anne E; Kretser, David Morritz de

doi:10.1055/s-2004-831893

Cited by 85 publications

(58 citation statements)

References 82 publications

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“…INH has been reported to be mainly produced by Sertoli cells in the testes of many animals species [2,23,24,28], including dogs [12]. The blood plasma INH concentration of cryptorchid men [3,7,21] and experimental cryptorchid rats [27] has been found to be lower than in normal men and rats.…”

Section: Discussionmentioning

confidence: 99%

“…Heat shock protein (HSP) 70 is the main protein produced abundantly in some tissues exposed to heat stress [22], and it induces the development of certain tumors [6,18,20]. Inhibin (INH) in male animals is a glycoprotein produced by Sertoli cells [23,24,28] and is composed of two subunits, an α-unit and a β-unit [8,23]. The bioactivity of INH-α is important for spermatogenesis in the testis [11,24,29] and is especially correlated with Sertoli cell function [19,21].…”

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confidence: 99%

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Testicular Superoxide Dismutase Activity, Heat Shock Protein 70 Concentration and Blood Plasma Inhibin-.ALPHA. Concentration of Dogs with a Sertoli Cell Tumor in a Unilateral Cryptorchid Testis

et al. 2007

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ABSTRACT. The proportions of Sertoli cell tumor (SCT), seminoma and Leydig cell tumor in 50 dogs with unilateral testicular tumors were 52%, 36% and 12%, respectively. The rate of occurrence of SCT in the cryptorchid testis was very high (71%). The testicular superoxide dismutase (SOD) activity, testicular heat shock protein (HSP) 70 concentration and peripheral blood plasma inhibin (INH)-α concentration of 10 dogs with a unilateral cryptorchid testis and no testicular tumors, 10 dogs with SCT in a unilateral cryptorchid testis and 10 normal dogs, all aged 5-15 years, were measured in order to identify high risk factors for the occurrence of SCT in the canine cryptorchid testis. The mean SOD activity in cryptorchid testes and SCTs was significantly lower and higher, respectively, than in normal testes (both P<0.01). The mean HSP 70 concentration in both cryptorchid testes and SCTs was significantly higher than in normal testes (both P<0.01). The mean plasma INH-α concentration of the cryptorchid and SCT dogs was significantly lower and higher, respectively, than in normal dogs (P<0.05 and 0.01, respectively). The low SOD activity in the cryptorchid testis, low blood plasma INH-α concentration of the cryptorchid dogs and high HSP 70 concentration in the SCTs may be related to the occurrence of SCT and tumor cell proliferation in canine cryptorchid testes.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Testicular Superoxide Dismutase Activity, Heat Shock Protein 70 Concentration and Blood Plasma Inhibin-.ALPHA. Concentration of Dogs with a Sertoli Cell Tumor in a Unilateral Cryptorchid Testis

et al. 2007

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“…Inhibins have an important role in male reproduction and reproductive organs (O'Connor & De Kretser 2004). Inhibin B is secreted by the testes, found in circulating blood, and correlates with male fertility.…”

Section: Textmentioning

confidence: 99%

Transforming growth factor-β receptor III downregulation in prostate cancer: is inhibin B a tumor suppressor in prostate?

Sharifi

Lechleider

Farrar

2007

Journal of Molecular Endocrinology

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The transforming growth factor-b (TGF-b) pathway plays dual roles in cancer, inhibiting epithelial cell growth under normal physiologic conditions, but promoting invasion and metastasis once growth inhibitory responses are lost. Two recent papers show that TGF-b receptor III is the most common TGF-b pathway component downregulated in prostate cancer. Here, we discuss the implications of these findings and what it may mean about the biology of this disease.

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“…Inhibin A and inhibin B provide endocrine negative feedback from the gonads to the pituitary gonadotrophs, but local autocrine/paracrine actions of inhibins are also evident in tissues that synthesise and secrete them (Hsueh et al 1987, Drummond et al 2004, O'Connor & De Kretser 2004. Disulphide-linked dimers of inhibin subunits form activins, the actions of which are opposed by inhibins in some cell types, most notably the pituitary gonadotroph, but not others .…”

Section: Introductionmentioning

confidence: 99%

Rodent adrenocortical cells display high affinity binding sites and proteins for inhibin A, and express components required for autocrine signalling by activins and bone morphogenetic proteins

Farnworth¹,

Wang²,

Leembruggen³

et al. 2006

Journal of Endocrinology

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Inhibins are expressed in the adrenal cortex, but little is known of their binding or role in the adrenal. The aims of the present study were, first, to establish whether a mouse adrenocortical (AC) cell line expresses inhibins/activins and bone morphogenetic proteins (BMP), along with proteins required for inhibin to antagonise activin and BMP actions and, secondly, to characterise and compare inhibin binding sites and proteins in the rat adrenal gland and AC cells. AC cells were found to: (1) express mRNA for multiple BMPs (BMP-2, -3, -4, -6, -8a), growth/ differentiation factors (GDF-1, -3, -5, -9), Lefty A and B, and the inhibin , A and B subunits (2) secrete inhibin A and inhibin B and (3) express mRNA encoding the inhibin co-receptor, betaglycan, along with activin and BMP type I (ALK2-7) and type II (ActRII, ActRIIB, BMPRII) receptors, and binding proteins (follistatin, BAMBI, gremlin ]inhibin A on both the primary rat adrenal and AC cells. The species of >220 kDa were shown by immunoprecipitation to include betaglycan, the species of 105 kDa is consistent in size with type II receptors for activin/BMP, and that of 62 kDa co-migrates with the inhibin-follistatin complex.In summary, the results show that inhibin A binds selectively and with both high and low affinity to AC cells via multiple binding proteins, including a single betaglycan-like species. The results support the role of glycosylated betaglycan in the high affinity binding of inhibin A, but provide consistent evidence from two independent sources of adrenal cells that inhibin A interacts with several membrane proteins in addition to those currently understood to mediate the anti-activin/BMP actions of inhibin.

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Inhibins in Normal Male Physiology

Cited by 85 publications

References 82 publications

Testicular Superoxide Dismutase Activity, Heat Shock Protein 70 Concentration and Blood Plasma Inhibin-.ALPHA. Concentration of Dogs with a Sertoli Cell Tumor in a Unilateral Cryptorchid Testis

Testicular Superoxide Dismutase Activity, Heat Shock Protein 70 Concentration and Blood Plasma Inhibin-.ALPHA. Concentration of Dogs with a Sertoli Cell Tumor in a Unilateral Cryptorchid Testis

Transforming growth factor-β receptor III downregulation in prostate cancer: is inhibin B a tumor suppressor in prostate?

Rodent adrenocortical cells display high affinity binding sites and proteins for inhibin A, and express components required for autocrine signalling by activins and bone morphogenetic proteins

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