Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle

Dzik, Artur; Lambert-Messerlian, Geralyn; Izzo, Vicente Mário; Soares, Jonatas Borges; Pinotti, José Aristodemo; Seifer, David B.

doi:10.1016/s0015-0282(00)01627-7

Cited by 52 publications

(21 citation statements)

References 21 publications

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“…Phelps et al(1998) found that the estradiol concentration measured on Day 4 of Gn therapy was highly predictive of successful ovulation induction and pregnancy outcome in GnRHa-rFSH cycles. This study confirmed previous studies and expanded some of their findings (Phelps et al, 1998;Ravhon et al, 2000;Dzik et al, 2000;Urbancsek et al, 2005b). We performed dynamic assays of basal inhibin B, estradiol, FSH, and LH.…”

Section: Discussionsupporting

confidence: 89%

“…This study confirmed and expanded the findings from previous studies (Phelps et al, 1998;Dzik et al, 2000;Ravhon et al, 2000). A total of 57 patents undergoing their first cycle of long protocol IVF or introcytoplasmic sperm injection (ICSI) treatment were studied, and serum inhibin B, estradiol, FSH, LH levels were detected four times in the IVF cycle: on Day 3 of the menstrual cycle, before the first administration of Gn (Day 0), on Day 1 after Gn therapy, and on Day 5 after Gn therapy.…”

Section: Introductionsupporting

confidence: 91%

“…Significance of inhibin B measurement after Gn stimulation in predicting the ovarian response and IVF pregnancy outcome Dzik et al(2000) found that the mean baseline inhibin B concentrations and the inhibin B concentration 24 h after exogenous follicle-stimulating hormone ovarian reserve test (EFORT) were significantly higher in good responders than that in poor responders. Thus, they concluded that inhibin B concentration 24 h after EFFORT may provide a method for predicting ovarian response to hyperstimulation in a subsequent IVF cycle.…”

Section: Discussionmentioning

confidence: 99%

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Dynamic measurements of serum inhibin B and estradiol: apredictive evaluation of ovarian response to gonadotrophin stimulation in the early stage of IVF treatment

Miao

Huang

2009

J. Zhejiang Univ. Sci. B

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Abstract:Objective: We dynamically measured serum inhibin B and estradiol in the early stage of hormonal stimulation to predict the ovarian response in in vitro fertilization (IVF) treatment. Methods: A total of 57 patients (<40 years of age) who underwent the first cycle of long protocol IVF or introcytoplasmic sperm injection (ICSI) treatment were included. Serum inhibin B, estradiol, follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels were measured four times: (1) on Day 3 of the menstrual cycle (basal); (2) on the day before the first administration of gonadotrophin (Gn) (Day 0); (3) on Day 1 of Gn therapy; and (4) on Day 5 of Gn therapy. Comparisons of these measurements with ovarian responses and pregnancy outcomes were made and analyzed statistically. Results: (1) On Day 1 and Day 5 of recombinant FSH (rFSH) stimulation, ovarian response, i.e., numbers of follicles, oocytes, fertilized oocytes, and embryos, had a positive correlation (r s =0.46~0.61, P=0.000) with raised inhibin B and estradiol concentrations, but a negative correlation (r s =−0.67~−0.38, P=0.000 or P<0.01) with total rFSH dose and total days of rFSH stimulation. (2) No significant variation (P>0.05) between the pregnant and non-pregnant groups on the basis of mean age or on all hormone concentrations at four times of the IVF cycle was observed. However, all the seven patients aged >35 years did not reach pregnancy. Conclusions: (1) Serum inhibin B and estradiol concentrations obtained shortly after Gn therapy may offer an accurate and early prediction of ovarian response; (2) Low levels of serum inhibin B and estradiol obtained shortly after Gn stimulation indicate the need for a longer period of Gn treatment and a higher daily dosage; (3) No obvious pregnancy difference among patients of age <35 years was found; however, IVF pregnancy outcome is significantly lower in women of age >35 years.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Dynamic measurements of serum inhibin B and estradiol: apredictive evaluation of ovarian response to gonadotrophin stimulation in the early stage of IVF treatment

Miao

Huang

2009

J. Zhejiang Univ. Sci. B

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“…Over the years, several groups have investigated the use of various basal markers such as FSH, age, inhibin B, oestradiol and dynamic tests such as CCCT, OST and G-test. 13,26 Some have reported that inhibin B is useful in predicting ovarian response, 10,11,14,15,27,28 whereas others have reported inhibin B does not add value to FSH, age or oestradiol. 9,17,29 In the menstrual cycle, inhibin B levels progressively rise and are at peak concentration around days 5-6 of the cycle.…”

Section: Discussionmentioning

confidence: 99%

Antral follicle count, anti‐mullerian hormone and inhibin B: predictors of ovarian response in assisted reproductive technology?

Muttukrishna

Mcgarrigle

Wakim

et al. 2005

BJOG

267

159

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Objective The objective of this study was to evaluate the relationship between anti-mullerian hormone (AMH), inhibin B and antral follicle count (AFC) with ovarian response. Design Retrospective study. Setting Fertility unit.Sample AFC was recorded, and a serum sample obtained on day 3 from all patients undergoing in vitro fertilisation (IVF). Patients were given 300 IU/L recombinant follicle stimulating hormone (FSH; Gonal F).The following day blood samples were collected. Methods Serum samples were assayed for FSH, AMH and inhibin B using commercial immunoassay kits and oestradiol using an in house assay. Main outcome measures Response to gonadotrophin stimulation and the number of eggs collected.Results AFC was negatively correlated to age (r ¼ À0.426, P < 0.001). Delta inhibin B (levels of inhibin B on day 4 minus day 3) had the best association to the number of eggs collected (r ¼ 0.533, P < 0.001) followed by basal AMH (r ¼ 0.51, P < 0.001) and AFC (r ¼ 0.505, P < 0.001). The number of eggs fertilised was significantly associated with basal AMH (r ¼ 0.592, P < 0.001) and inhibin B (r ¼ 0.548, P < 0.001). AMH with a cutoff of 0.2 ng/mL had the best sensitivity (87%) and specificity (64%) in predicting poor response. A cumulative score using basal FSH, basal AMH, delta E 2 (levels of oestradiol on day 4 minus day 3), delta inhibin B, AFC and age gives the best predictive statistics to identify poor responders with 87% sensitivity and 80% specificity and a positive likelihood ratio of 4.36. Conclusion Delta inhibin B had the best positive association with the number of eggs collected and basal AMH is the single best predictor of poor response. AFC has a significant association with the number of eggs collected and is predictive of clinical pregnancy. It is evident that a single parameter is of limited value in predicting ovarian response. However, we have demonstrated a cumulative score using all the above markers could be useful in predicting poor response.

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“…Unfortunately, more detailed analyses concluded that early follicular phase inhibin B serum levels are only of limited value in predicting response during ovarian hyperstimulation (18 -21). Dynamic inhibin B testing with FSH stimulation (22,23) or gonadotropin releasing hormone (GnRH) agonist administration (24) appears to correlate better with ovarian response. A good correlation was also observed between inhibin B concentrations during ovarian hyperstimulation and the number of oocytes retrieved (25,26).…”

Section: Introductionmentioning

confidence: 99%

Relationship between inhibin A and B, estradiol and follicle growth dynamics during ovarian stimulation in normo-ovulatory women

Laven¹,

Jong²,

Fauser³

2005

eur j endocrinol

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Objective: To investigate the relationship between serum concentrations of inhibin A, inhibin B and estradiol (E 2 ) and the number of developing follicles during the administration of exogenous follicle-stimulating hormone (FSH) in various regimens in normo-ovulatory volunteers and to evaluate if inhibins act as suitable markers for the number of developing follicles during ovarian stimulation. Design and methods: Serial hormone determinations and assessment of follicle numbers were carried out during unstimulated cycles and during various interventions with exogenous FSH. Subjects were randomized for FSH administration into the following groups: a single high dose (375 IU) during the early follicular phase (group A), 5 consecutive low doses (75 IU/day) starting in the mid follicular phase (group B) or daily low doses (75 IU/day) during the early to late follicular phase (starting on cycle days 3, 5 or 7; groups C, D and E respectively). Results: Extending the FSH window increases the number of small antral follicles and hence inhibin B serum concentrations. If such an intervention results in multi-follicular growth, mid follicular phase inhibin B (P ¼ 0.001) as well as late follicular phase inhibin B and inhibin A levels are significantly (P , 0.05 and P , 0.01 respectively) increased compared with mono-follicular cycles or the natural cycle. Although mid follicular inhibin B levels correlated well with the number of small antral (P , 0.05) and pre-ovulatory (P , 0.001) follicles in the late follicular phase, mid follicular inhibin A and estradiol serum concentrations only correlated with the number of pre-ovulatory follicles (P , 0.001 and P , 0.01 respectively). Conclusions: The present data extend our understanding of the relationship between follicle dynamics, serum inhibins and FSH during ovarian hyperstimulation. However, although mid follicular inhibin B does correlate with the number of developing follicles, it does not facilitate the identification of women at risk for multiple follicle development.European Journal of Endocrinology 152 395-401

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Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle

Cited by 52 publications

References 21 publications

Dynamic measurements of serum inhibin B and estradiol: apredictive evaluation of ovarian response to gonadotrophin stimulation in the early stage of IVF treatment

Dynamic measurements of serum inhibin B and estradiol: apredictive evaluation of ovarian response to gonadotrophin stimulation in the early stage of IVF treatment

Antral follicle count, anti‐mullerian hormone and inhibin B: predictors of ovarian response in assisted reproductive technology?

Relationship between inhibin A and B, estradiol and follicle growth dynamics during ovarian stimulation in normo-ovulatory women

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