Inhibin B in seminiferous tubules of human testes in normal spermatogenesis and in idiopathic infertility

Demyashkin, Grigory

doi:10.1080/19396368.2018.1478470

Cited by 15 publications

(11 citation statements)

References 16 publications

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“…Pulsatile release of gonadotropin-releasing hormone (GnRH) from the hypothalamus stimulates the release of FSH and LH. Inhibin B and estradiol are the primary inhibitors of FSH secretion (21–23). Several other pituitary-regulatory proteins, such as activin and follistatin, have been implicated in FSH secretion and action (22).…”

Section: Introductionmentioning

confidence: 99%

FSH Beyond Fertility

et al. 2019

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The traditional view of follicle-stimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data suggest that elevated serum FSH may play a significant role in the evolution of bone loss and obesity, as well as contributing to cardiovascular and cancer risk. This review summarizes recent data on FSH action beyond reproduction.

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Section: Introductionmentioning

confidence: 99%

FSH Beyond Fertility

et al. 2019

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“…The level of serum inhibin B is significantly correlated with testicular volume and total sperm count, which directly reflects testicular spermatogenic function and fertility 39 . One study found that the content of inhibin B in testicular convoluted seminiferous tubules in infertile people was significantly lower than that in control individuals 40 . The results of this study showed that the concentration of inhibin B in the nutrient medium of TM4 cells decreased after exposure to 2,4‐D in a dose‐dependent manner.…”

Section: Discussionmentioning

confidence: 57%

“…39 One study found that the content of inhibin B in testicular convoluted seminiferous tubules in infertile people was significantly lower than that in control individuals. 40 The results of this study showed that the concentration of inhibin B in the nutrient medium of TM4 cells decreased after exposure to 2,4-D in a dose-dependent manner.…”

Section: Discussionmentioning

confidence: 60%

Mechanism of 2,4‐Dichlorophenoxyacetic acid‐induced damage to rat testis via Fas/FasL pathway and the protective effect of Lycium barbarum polysaccharides

Zhou

Wang

et al. 2022

Environmental Toxicology

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The herbicide 2,4-Dichlorophenoxyacetic acid (2,4-D) is widely used to control broadleaved weeds and has been associated with male infertility. We studied the molecular mechanisms of 2,4-D induced male reproductive system damage and the protective effects of Lycium barbarum polysaccharides (LBP) using Sprague Dawley rats and TM4 cells. Treatment with 2,4-D caused architectural and functional changes in the testis, including collapsed and atrophied seminiferous tubules with reduced number of spermatozoa, scarce sperm in the epididymal duct, low levels of serum testosterone, decreased superoxide dismutase and glutathione peroxidase activity, high malondialdehyde content, and increased apoptosis in the testis and epididymis. The expression of Fas, FasL, FADD, Pro-caspase-8, Cleaved-Caspase-8, Pro-Caspase-3, and Cleaved-Caspase-3 were significantly increased in the testicular tissue of 2,4-D-treated rats. The proliferative activity of TM4 cells decreased with an increase in dose and time of 2,4-D exposure, along with enhanced Fas/Fas ligand expression and a decreased concentration of inhibin B in TM4 cell culture medium. Depletion of Fas by specific shRNA transfection reversed the effects of 2,4-D in TM4 cells, further confirming the involvement of death receptor pathway in 2,4-Dmediated apoptosis of sertoli cells. Treatment with LBP also reversed the effects of 2,4-D in testicular cells, resulting in improved cell architecture along with enhanced proliferative capacity. Moreover, in response to LBP treatment of Sertoli cells, the content of inhibin B increased, the level of reactive oxygen species and malondialdehyde decreased, the activities of superoxide dismutase and glutathione peroxidase increased, and the rate of apoptosis as well as the expression of Fas/Fas ligand signaling pathway proteins decreased.

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“…The reduced level of testosterone and prolactin might be due to hyperglycemia that increased free radical production to induce oxidative stress, triggered testicular tissue, particularly Leydig cells, and reduced their function associated with reduced beta-cells function and increased insulin resistance [40,43,44]. In contrast, the decreased level of testosterone was the main reason for a high level of LH due to the feedback mechanism, whereas the high level of FSH might be due to dysfunction of Sertoli cells and seminiferous tubules that reduced inhibin secretion [45].…”

Section: Discussionmentioning

confidence: 99%

Effect of honey bee venom on the histological changes of testes and hormonal disturbance in diabetic mice

2022

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Background and Aim: Hyperglycemia associated with hyper- or hypo-insulinemia is a hallmark of type 2 diabetes mellitus, which is firmly linked to decreased male infertility. Recently, bee venom (BV) has shown potential health prosperities, including antidiabetic; however, no study focuses on the effect of BV on male fertility in diabetic conditions. This study aimed to detect the effect of BV on histological and hormonal alteration of the testis in diabetic mice. Materials and Methods: Twenty adult male mice were selected and assigned to four groups: Control, diabetic (150 mg/kg alloxan), BV1 (diabetic + 0.5 mg/kg BV), and BV2 (diabetic + 1 mg/kg BV). After 35 days, the serum levels of glucose, insulin, testosterone, follicular-stimulating hormone, luteinizing hormone, and prolactin were estimated. The histological structure of the testes was also evaluated. Results: Alloxan-induced hyperglycemia and decreased insulin concentrations were reversed significantly by BV. Furthermore, diabetic mice exhibited various alterations in fertility hormones, while these disturbances were improved considerably to normal concentrations by BV. Similarly, alloxan-induced changes in sperm and testis histological parameters such as motility, viability, abnormality, sperm count, the number and diameter of seminiferous tubules, and the number of Leydig and Sertoli cells were significantly ameliorated to the normal condition by BV. Changes in the number, size, and shape of seminiferous tubules, the number of Leydig and Sertoli cells, and initial degeneration and vacuolization in interstitial cells and spermatogonia and spermatocyte were seen in diabetic mice. All these changes were shifted almost to normal structure by BV. Conclusion: The BV could be used as an alternative therapeutic agent that manages the markers related to diabetic conditions concomitant with the improved histological structure of the testes and hormone production to accelerate male fertility.

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Inhibin B in seminiferous tubules of human testes in normal spermatogenesis and in idiopathic infertility

Cited by 15 publications

References 16 publications

FSH Beyond Fertility

FSH Beyond Fertility

Mechanism of 2,4‐Dichlorophenoxyacetic acid‐induced damage to rat testis via Fas/FasL pathway and the protective effect of Lycium barbarum polysaccharides

Effect of honey bee venom on the histological changes of testes and hormonal disturbance in diabetic mice

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