Inhibin assays of ovarian cyst liquid obtained by needle aspiration may allow differential diagnosis between functional and organic cysts

Aspiration Cytology of 147 Adnexal Cysts with Histologic Correlation

“…In order to improve the diagnostic yield, current efforts are geared at combining the cytologic examination (including immunocytochemical study with antiinhibin 17 ) with hormonal determinations (estradiol, gonadotropins and inhibin) and tumor markers (CA-125, CA-19.9, CEA). 2,16,17,22,23,26,32 By using such a combination, it may be possible to increase diagnostic sensitivity, which is important in screening functional cysts in women receiving fertility treatment. In spite of all these efforts, it is not always possible to confirm the functional nature of the cyst.…”

“…Gross features were extremely variable, with a serous appearance prevailing in 18 cases, followed by hemorrhagic (7 cases), serohemorrhagic (5), brown-black (2) and colorless (2) ithelial cells, with or without a papillary pattern, were present in moderate-abundant amounts in 10 cases ( Figure 4) and scarcely in 7. Ciliated bodies were not identified.…”

“…1,15,18 In spite of skepticism and initial resistance, the aspiration of adnexal cysts with sonographic benign criteria is now employed not only as a diagnostic tool 2,16,17,[22][23][24]31,32 but also as treatment for nonneoplastic cysts. 5,7,10,12,14,20,21,30 This rapid and well-tolerated procedure has been used for aspiration of cysts in pregnant women 11,14 and prenatally, 3,27 but, like any other invasive techniques, it is not absolutely risk free.…”

Cystic Adult Ovarian Granulosa Cell Tumor as a Potential Source of False Negative Diagnosis in Ovarian Cytology

“…The cytologic assessment is performed in association with the measurement of hormonal levels (estradiol, gonadotropins and inhibin) and the study of tumor markers (CEA, CA-125 and CA 19.9). 3,9,[12][13][14][15][16]20,27,28 Most adnexal cysts are located in the ovary, are benign and include functional cysts, endometriotic cysts and benign cystic neoplasms (cystoadenomas and teratomas). However, a small percentage of malignant tumors, usually epithelial (borderline tumors or tumors of low malignant potential 13 ) can be also present.…”

Assessment of Unilocular Ovarian Cysts in Premenopausal Women Using Transvaginal Ultrasonography, Aspiration Cytology and Estradiol Content

“…From and therapeutic approach, is opposed by others because of the high recurrence rate (19,20) and the theoretical risk of spreading malignancy (21,22) …”