Inhibin and CD99 (MIC2) expression in uterine stromal neoplasms with sex-cord-like elements

Baker, Robin J.; Hildebrandt, Richard H; Rouse, Robert V.; Hendrickson, Michael; Longacre, Teri A.

doi:10.1016/s0046-8177(99)90093-x

Cited by 118 publications

(73 citation statements)

References 36 publications

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“…25 Areas of sex-cord differentiation may also be positive for inhibin, calretinin, CD 99, and Melan-A. 26 Desmin and h-caldesmon are usually positive in areas of smooth muscle differentiation; 27,28 desmin may be occasionally positive in conventional areas or areas of sex-cord differentiation. Rarely, LGESS may contain cells with clear cytoplasm, which can be HMB45 positive.…”

Section: Endometrial Stromal Sarcoma Low Gradementioning

confidence: 99%

Practical issues related to uterine pathology: endometrial stromal tumors

Nucci

2016

Modern Pathology

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Uterine mesenchymal tumors continue to be a challenge to diagnose due to their non-specific clinical presentation, often non-distinctive gross appearance, varied (and many times overlapping) morphologic appearance, and unsuspected pitfalls in immunohistochemical expression. This review will focus on endometrial stromal tumors and those features that help in their distinction. In particular, a practical approach to the diagnosis of endometrial stromal neoplasia will be covered including recognition as a stromal process in a biopsy/curettage and distinction from a highly cellular leiomyoma. In addition, distinction of a stromal nodule from a low-grade endometrial stromal sarcoma (LGESS) and stromal sarcoma with limited infiltration in a hysterectomy specimen will be covered. The salient features that help distinguish a LGESS from a uterine tumor resembling ovarian sex-cord tumor as well as high-grade endometrial stromal sarcoma, the latter a tumor recently reintroduced in the WHO classification will also be discussed. Finally, a practical approach to the diagnosis of undifferentiated uterine sarcoma (UUS) will be presented.

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Section: Endometrial Stromal Sarcoma Low Gradementioning

confidence: 99%

Practical issues related to uterine pathology: endometrial stromal tumors

Nucci

2016

Modern Pathology

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“…CD-99 (MIC-2) is a pseudo-autosomal gene located on the short arm of the X and Y chromosomes [28][29][30][31]. It encodes for glycoproteins p30 and p32 that are expressed mainly on the cell membranes of a wide variety of normal tissues and several neoplasms.…”

Section: Introductionmentioning

confidence: 99%

A comparison of palpable and impalpable cryptorchid testes using CD‐99 immunohistochemistry

et al. 2003

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tubule (MGCT) were calculated using immunohistochemistry for CD-99, a Sertolicell marker, to classify germ cells more accurately. RESULTSSixty-three testes (33%) were impalpable; the median age at the time of surgical exploration was 23 months for both groups. The mean ( SD ) testicular volume for the impalpable and palpable groups were 0.83 (0.38) and 1.22 (0.54) mL, respectively. Using fitted curves of size vs age, impalpable testes were smaller than palpable testes at all ages, with the difference nearly statistically significant ( P < 0.06). The MTD, TFI and MGCT decreased with age in both groups, with no statistically significant differences between the groups. A sub-analysis of abdominal and extraabdominal testes confirmed no significant differences. CONCLUSIONImpalpable testes are smaller at the time of exploration than palpable cryptorchid testes. However, histological factors predict that impalpable testes have a significant chance of future fertility and therefore orchidopexy is appropriate. CD-99 immunohistochemistry makes objective morphological information easier to obtain.

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“…True Leydig cell differentiation has not been described in these tumors, although some cases have been observed to contain luteinized-like cells with abundant eosinophilic or foamy cytoplasm. [4][5][6][7] Numerous immunohistochemical and ultrastructural studies have attempted to phenotype the sex cord-like cells in UTROSCT and ESTSCLE, with variable evidence supporting myoid, [8][9][10][11][12][13][14] epithelial, 4,15 and true sex cord differentiation. 6,7,[16][17][18][19][20] Specifically, inhibin and CD99, 3,6,7,14,[17][18][19][20][21] as well as Melan-A, 19,21 and most recently, calretinin, 7,20 have been utilized as immunohistochemical markers of sex cord differentiation in UTROSCT and ESTSCLE based on application of these markers to sex cordstromal tumors of the ovary.…”

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confidence: 99%

Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation

2006

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In this study, we present the clinicopathologic features and immunophenotypic characteristics of five cases of uterine tumors resembling ovarian sex cord tumors and three cases of endometrial stromal tumors with sex cord-like elements, with emphasis on immunohistochemical markers of sex cord differentiation. The mean patient age was 42 years (range 19-69 years), and vaginal bleeding was the most common clinical presentation. The tumors were usually polypoid masses arising in the uterine fundus, with a mean tumor size of 6.7 cm. Sex cord patterns in uterine tumors resembling ovarian sex cord tumors, including anastomosing cords, trabeculae, small nests, tubules, and in one case, a striking retiform architecture with Leydig-like cells, comprised from 70 to 100% of the tumor volume. All uterine tumors resembling ovarian sex cord tumors were positive for two or more markers of sex cord differentiation; all five cases showed strong immunoreactivity for calretinin, with coexpression of CD99 (four cases), Melan-A (two cases), and inhibin (two cases). Endometrial stromal tumors with sex cord-like elements were less frequently positive for markers of sex cord differentiation, with each case positive for one marker (calretinin, two cases; CD99, one case). In addition, all eight cases were frequently positive for cytokeratin, CD10, vimentin, estrogen receptor, and progesterone receptor; desmin immunoreactivity, when present, was limited to minor foci of smooth muscle. Overall, the morphologic and immunohistochemical findings in uterine tumors resembling ovarian sex cord tumors strongly support that these unusual uterine tumors are polyphenotypic neoplasms with true sex cord differentiation.

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Inhibin and CD99 (MIC2) expression in uterine stromal neoplasms with sex-cord-like elements

Cited by 118 publications

References 36 publications

Practical issues related to uterine pathology: endometrial stromal tumors

Practical issues related to uterine pathology: endometrial stromal tumors

A comparison of palpable and impalpable cryptorchid testes using CD‐99 immunohistochemistry

Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation

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