Inhibidores de tirosin quinasa para el tratamiento de cáncer pulmonar de células no pequeñas: una necesidad desatendida

Gómez, X.; Valdez, Nella; Paredes, Ricardo

doi:10.17843/rpmesp.2017.342.2690

Cited by 1 publication

(2 citation statements)

References 3 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Active tyrosine kinase causes the growth of certain cancer cells, which is halted by administering inhibitors, leading to the prevention of proliferation and effective cancer treatment. [1][2][3] The benzimidazol-quinolinone compound, (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene] quinolin-2-one, dovitinib (TKI258, Figure 1) is a small-molecule multi-kinase inhibitor used to treat different types of cancer. 4,5 Dovitinib was approved by the US Food and Drug Administration (FDA) as a TKI for the treatment of cancer.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Dovitinib was approved by the US Food and Drug Administration (FDA) as a TKI for the treatment of cancer. 6 Dovitinib is a potent inhibitor of receptor tyrosine kinases, including fibroblast growth factor receptor (FGFR), [1][2][3] vascular endothelial growth factor (VEGFR) [1][2][3] and platelet-derived growth factor receptor (PDGFR). Dovitinib has displayed excellent antitumor and antiangiogenic effects in preclinical models of colon, breast, bladder, pancreatic, and renal cancers.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

<p>A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma</p>

AlRabiah¹,

Kadi²,

Aljohar³

et al. 2020

DDDT

View full text Add to dashboard Cite

Background: Dovitinib (TKI 258) is a small-molecule multi-kinase inhibitor for the treatment of different types of cancer. There is currently no validated method for its quantitative determination; therefore, we aimed to develop a reliable method to assay dovitinib. Method and Results: An electrospray ionization tandem mass spectrometry (ESI-MS /MS) method was used to separate dovitinib using an analytical C18 column (50 × 2.1 mm, 1.8 μm) at 25°C. Bosutinib was used as the internal standard (IS). Dovitinib was extracted from mouse plasma using a precipitation procedure. The mobile phase consisted of 10 mM ammonium formate: acetonitrile (68:32, v/v, pH 4.3) run at a rate of 0.3 mL min −1. MS detection was performed in the positive ion mode. Multiple reaction monitoring transitions were 393→337 and 393→309 for dovitinib, and 530→141 and 530→113 for bosutinib. The investigated method was validated as a bio-analytical method based on FDA guidelines. The linearity of the developed method was over the range of 5-500 ng mL, −1 coefficient of determination (r 2 = 0.9998). The average intra-day recovery and relative standard deviation (RSD) of the quality control (QC) sample were 97.24% and 1.32%, whereas the overall inter-day accuracy and precision were 97.99% and 0.54%, respectively. Dovitinib was stable during sample storage and handling conditions. Furthermore, the dilution integrity of the method was demonstrated by good recovery (97-99%) and RSD values (0.5-0.7%). Conclusion: This method was selectively sensitive and exhibited no matrix effect, with an acceptable accuracy and precision according to the FDA guidelines. The developed method could be efficiently used for pharmacokinetic studies of dovitinib.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma</p>

AlRabiah¹,

Kadi²,

Aljohar³

et al. 2020

DDDT

View full text Add to dashboard Cite

show abstract

Inhibidores de tirosin quinasa para el tratamiento de cáncer pulmonar de células no pequeñas: una necesidad desatendida

Abstract: Sr. editor. El cáncer de pulmón es un problema de salud pública a nivel mundial, con un estimado anual de 1,59

Cited by 1 publication

References 3 publications

<p>A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma</p>

<p>A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma</p>

Contact Info

Product

Resources

About