Inheriting a structural scaffold for Golgi biosynthesis

Abstract

In animal cells, the Golgi complex undergoes reversible disassembly during mitosis. The disassembly/reassembly process has been intensively studied in order to understand the mechanisms that govern organelle assembly and inheritance during cell division. A long-standing controversy in the field has been whether formation of Golgi structure is template-mediated or self-organizes from components of the endoplasmic reticulum. A recent study1 however, has demonstrated that a subset of proteins that form a putative Golgi matrix can be inherited during cell division in the absence of membrane input from the endoplasmic reticulum. The outcome of this study suggests that a templating mechanism for the formation of Golgi structure may exist. This study has important implications for understanding mechanisms that govern Golgi biogenesis.

Molecules into Cells: Specifying Spatial Architecture

“…Centrosomes, which nucleate the microtubules that organize themselves into a cytoskeleton, do so by providing some kind of template. Self-construction is clearly part of Golgi duplication, but there is evidence that it takes place on a matrix or template that carries over from one generation to the next (145); and there are organisms whose Golgi apparatus undergoes what looks remarkably like true division (77,115). Biological self-organization is real and important, but when it takes place in a living cell it is subject to constraint and control by the system as a whole.…”

Beyond Raiding: Unveiling the Epic Voyages of the Vikings (793-1066 AD)

“…[6] Additional inclusion of, the Faroe Islands, Iceland, Greenland, and Vínland is warranted. [7] We could not include, Orkney, Shetland and parts of Ireland, because although they remained politically 'Scandinavian' until recently, they were not homogeneously so -there were pre-existing peoples like the Anglo-Saxons who were around past 1066's Norman Conquest. [8] We have also not included the Rus Vikings, as they are often separate and beyond our scope.…”

“…[7] We could not include, Orkney, Shetland and parts of Ireland, because although they remained politically 'Scandinavian' until recently, they were not homogeneously so -there were pre-existing peoples like the Anglo-Saxons who were around past 1066's Norman Conquest. [8] We have also not included the Rus Vikings, as they are often separate and beyond our scope. [9] This essay has therefore replaced 'Vikings' with Northmen' (regardless of gender) as a people group with origins in what is now modern-day Scandinavian, and its ancillary locations -Iceland, Greenland etc.…”

Liminaridad y licantropía: sobre los ritos de paso y la ascendencia en «Vǫlsunga Saga»

“…Estos estudios pueden compararse con los resultados de otros trabajos sobre Britania e Irlanda, Knight, 2019. 53 En un exhaustivo estudio dedicado a las relaciones establecidas entre grupos humanos y los animales en el contexto escandinavo, Jennbert, 2011, p. 11 señala que las actitudes hacia los animales están relacionadas nórdica, el lobo, junto con el cuervo y el águila, aparece intrínsicamente conectado a la guerra y la muerte, posicionándose asimismo junto con los Jǫtnar, las fuerzas del caos y el Ragnarǫk 54 . En el Gylfaginning, el Sol y la Luna huyen constantemente de los lobos Skǫll y Hati, pero serán finalmente devorados por ellos, hecho que presagiará el Ragnarǫk y el destino final del orden hasta entonces conocido 55 .…”