Inherited thrombophilia transpires with severe coronary arterial thrombosis in wide range of age backgrounds: A report of 3 cases

Alkaff, Firas Farisi

doi:10.1016/j.amsu.2022.103730

Cited by 1 publication

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are no established guidelines on the indication and duration of prophylactic oral anticoagulation treatment in patients with inherited thrombophilia with the first arterial thrombotic event. In published literature, there are reported studies and case series about the use of anticoagulation treatment in patients with hereditary thrombophilia after MI to prevent recurrent cardiovascular events [4]. In our case, the patient was discharged with recommendation of preventive dose of oral anticoagulation treatment and after 1-year follow-up, the patient was in a good clinical condition with no recurrent cardiovascular event or bleeding complications.…”

Section: Discussionmentioning

confidence: 70%

“…The prevalence of hereditary thrombophilia in the general population is rare (approximately 0.25-0.5%). Inherited thrombophilia due to a combination of Leiden factor V and MTHFR C677T gene mutation is generally associated with venous thromboembolic events, whereas their role in arterial thrombosis remains uncertain [4].…”

Section: Discussionmentioning

confidence: 99%

“…Inherited thrombophilia represents a wide range of genetic disorders which are characterized by an increased tendency to develop thrombotic formations. It leads to a hypercoagulable state that results in venous thromboembolic complications, as well as arterial thrombotic events such as ischemic stroke and MI [4].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Curious Case of Acute STEMI in a Young Patient; Things are Not Always What They Seem

Vraynko,

Zafirovska,

Dimitrovska

et al. 2023

SEE J Cardiol

View full text Add to dashboard Cite

BACKGROUND: Acute myocardial infarction (MI) is a rare occurrence in patients under 40 years of age without positive family history for coronary artery disease (CAD). Genetic conditions as inherited thrombophilia can lead to a hypercoagulable state, resulting in thromboembolic events and arterial thrombosis. CASE SUMMARY: We present a case of a 35-year-old male patient who presented to the emergency room with an inferior MI after a strenuous cycling exercise. An urgent coronary angiography showed thrombotic formations in the right coronary artery without atherosclerotic plaques. Plain old balloon angioplasty and thrombus aspiration were performed, which was followed by GP IIb/IIIa inhibitor infusion and unfractionated heparin for 24 h. From past medical history, the patient had COVID-19 like symptoms 20 days before the event and had his first dose of anti- COVID vaccine 2 weeks prior. After additional testing, molecular genetic analysis results revealed the patient to be heterozygous for factor V Leiden (FVL) and homozygous for methylenetetrahydrofolate reductase C677T gene mutation. The patient was discharged on direct oral anticoagulant and antiplatelet therapy. After 1-year follow-up, he had no symptoms or recurrent cardiovascular events. CONCLUSION: Inherited thrombophilia is а significant risk factor for CAD and performing genetic testing in younger patients with a cardiovascular event and plays an important role for adequate treatment and prophylaxis from recurrent complications. The use of oral anticoagulation for prophylaxis is shown to be effective in these patients. However, further studies are needed to prove their exact role and duration of treatment.

show abstract

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%