Inherited stress resistance and longevity: a stress theory of ageing

Parsons, P. A.

doi:10.1038/hdy.1995.126

Cited by 69 publications

(36 citation statements)

References 55 publications

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“…Moreover, studies performed on Drosophila indicate that the protective effect of heat hardening is sustained long after Hsp70 expression returns to prestress level (Krebs and Feder 1997;Dahlgaard et al 1998), suggesting that factors other than Hsps may contribute to protection against heat. Indications of connections between stress in general and low metabolic rate (Hoffmann and Parsons 1991) and the stress theory of aging (Parsons 1995) support this view, and it is thus likely that genes involved in basal and induced heat resistance are not necessarily the same. (Tusher et al 2001) for all genes on the array.…”

Section: Introductionmentioning

confidence: 71%

Phototransduction genes are up-regulated in a global gene expression study of Drosophila melanogaster selected for heat resistance

Nielsen

Sørensen²,

Kruhøffer³

et al. 2006

Cell Stress Chaper

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The genetic architecture underlying heat resistance remains partly unclear despite the well-documented involvement of heat shock proteins (Hsps). It was previously shown that factors besides Hsps are likely to play an important role for heat resistance. In this study, gene expression arrays were used to make replicate measurements of gene expression before and up to 64 hours after a mild heat stress treatment, in flies selected for heat resistance and unselected control flies, to identify genes differentially expressed in heat resistance-selected flies. We found 108 genes up-regulated and 10 down-regulated using the Affymetrix gene expression platform. Among the up-regulated genes, a substantial number are involved in the phototransduction process. Another group of genes up-regulated in selected flies is characterized by also responding to heat shock treatment several hours after peak induction of known Hsps revert to nonstress levels. These findings suggest phototransduction genes to be critically involved in heat resistance, and support a role for components of the phototransduction process in stress-sensing mechanisms. In addition, the results suggest yet-uncharacterized genes responding to heat stress several hours after treatment to be involved in heat stress resistance. These findings mark an important increase in the understanding of heat resistance.

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Section: Introductionmentioning

confidence: 71%

Phototransduction genes are up-regulated in a global gene expression study of Drosophila melanogaster selected for heat resistance

Nielsen

Sørensen²,

Kruhøffer³

et al. 2006

Cell Stress Chaper

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“…Previous studies in Drosophila have shown that flies selected for increased stress resistance have longer lifespans. 36,37 Furthermore, this increased resistance to stress is positively correlated with lipid and water content. 38,39 We, therefore, tested green tea's ability to increase stress resistance.…”

Section: Gtps Protect Against Iron Toxicitymentioning

confidence: 96%

Green Tea Polyphenols Extend the Lifespan of MaleDrosophila melanogasterWhile Impairing Reproductive Fitness

Lopez

Schriner

Okoro

et al. 2014

Journal of Medicinal Food

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Green tea is a popular beverage believed to have many health benefits, including a reduction in the risks of heart disease and cancer. Rich in polyphenolic compounds known as catechins, green tea and its components have been shown to increase the lifespan of various animal models, including Drosophila melanogaster. Here, we investigated the genderspecific effects of green tea on the lifespan of fruit flies and observed that green tea extended the lifespan of male flies only. This effect was found to be independent of typical aging interventions, such as dietary restriction, modulation of oxidative energy metabolism, and improved tolerance to environmental stresses. The one exception was that green tea did protect male flies against iron toxicity. Since there is an inverse correlation between lifespan and reproduction, the impact of green tea on male reproductive fitness was also investigated. We found that green tea negatively impacted male fertility as shown by a reduced number of offspring produced and increased mating latency. We further identified that the lifespan extension properties of green tea was only observed in the presence of females which alludes to a reproductive (or mating) dependent mechanism. Our findings suggest that green tea extends the lifespan of male flies by inhibiting reproductive potential, possibly by limiting iron uptake. To our knowledge, our study is the first to report the negative impact of green tea on Drosophila male reproduction. Our results also support previous studies that suggest that green tea might have a negative effect on reproductive fitness in humans.

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“…Hormesis is the adaptive response to small harmless doses of a potentially fatal environmental or intrinsic stress stimulus, which renders the organism resistant to increased doses of this particular stressor. The signalling pathways that mediate resistance or adaptation to stress are also involved in longevity and have been already introduced in previous chapters (Calabrese et al, 2011;Johnson et al, 2002;Parsons, 1995). In this part of the review, we highlight autophagy as an integral component of several stress response mechanisms, which represents a conserved stress coping strategy in eukaryotes.…”

Section: Environmental/cellular Stress Signals Induce Autophagy-mediamentioning

confidence: 96%

Autophagy and ageing: Insights from invertebrate model organisms

Lionaki

Markaki

Tavernarakis

2013

Ageing Research Reviews

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a b s t r a c tAgeing in diverse species ranging from yeast to humans is associated with the gradual, lifelong accumulation of molecular and cellular damage. Autophagy, a conserved lysosomal, self-destructive process involved in protein and organelle degradation, plays an essential role in both cellular and whole-animal homeostasis. Accumulating evidence now indicates that autophagic degradation declines with age and this gradual reduction of autophagy might have a causative role in the functional deterioration of biological systems during ageing. Indeed, loss of autophagy gene function significantly influences longevity. Moreover, genetic or pharmacological manipulations that extend lifespan in model organisms often activate autophagy. Interestingly, conserved signalling pathways and environmental factors that regulate ageing, such as the insulin/IGF-1 signalling pathway and oxidative stress response pathways converge on autophagy. In this article, we survey recent findings in invertebrates that contribute to advance our understanding of the molecular links between autophagy and the regulation of ageing. In addition, we consider related mechanisms in other organisms and discuss their similarities and idiosyncratic features in a comparative manner.

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Inherited stress resistance and longevity: a stress theory of ageing

Cited by 69 publications

References 55 publications

Phototransduction genes are up-regulated in a global gene expression study of Drosophila melanogaster selected for heat resistance

Phototransduction genes are up-regulated in a global gene expression study of Drosophila melanogaster selected for heat resistance

Green Tea Polyphenols Extend the Lifespan of MaleDrosophila melanogasterWhile Impairing Reproductive Fitness

Autophagy and ageing: Insights from invertebrate model organisms

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