Inherited Sex-Mosaic in Man

Pettersson, Gustaf; Bonnier, Gert

doi:10.1111/j.1601-5223.1937.tb02661.x

Cited by 57 publications

(4 citation statements)

References 12 publications

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“…A collection of literature shows that in patients with intra-abdominal testes, both gonads are found in analogous position with the ovaries, with a rudimentary uterus at the center where the remains of the Muller ducts inhibit the mobilization of the testes to the scrotum. 5 …”

Section: Discussionmentioning

confidence: 99%

A rare case report - Ovary attached to testicle inside hernia sac

Maloku

Shabani

Haliti

et al. 2021

Urology Case Reports

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We report the case of a 67-year-old man, father of 3 children with left indirect inguinal hernia containing uterus with cervix, fallopian tube and an ovary attached to the testicle, also spread ovarian tissue and right congenital cryptorchidism. Coincidentally detected during an operation for left inguinal hernia. Persistent Mullerian duct syndrome is a rare form of male pseudo-hermaphroditism detected coincidently during surgical operation on cryptorchidism or inguinal hernia.

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Section: Discussionmentioning

confidence: 99%

A rare case report - Ovary attached to testicle inside hernia sac

Maloku

Shabani

Haliti

et al. 2021

Urology Case Reports

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“…In 1937, Pettersson and Bonnier described a family in which three phenotypic females with primary amenorrhea presented with inguinal masses; all three had blind vaginal pouches, absence of internal female genital structures, and testes [80]. These cases are presumed to represent individuals with complete androgen insensitivity (CAIS).…”

Section: Testes Ovaries and Adrenal Cortexmentioning

confidence: 99%

The Long Path to Our Current Understanding Regarding Care of Children with Differences/Disorders of Sexual Development

et al. 2022

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Testes were associated with maleness from antiquity, and ancient societies had fanciful myths about the origins of the sexes and about fetal sexual development. 17th century anatomists developed the concept that mammals developed from eggs and discovered sperm in semen; in 1878, Hertwig observed sperm entering eggs (of sea urchins), establishing the cellular basis of sex development. Individuals with atypical genitalia were known clinically in the 17th century, with much debate about their origins, but by the late 19th century it was generally accepted that gonads determined sex, and that sex determined gender role. Testosterone was isolated in 1935, and Alfred Jost showed that both circulating testosterone and diffusible anti-Mullerian hormone were needed for male development. Patients with apparent androgen insensitivity were reported in 1937 and shown to be unresponsive to exogenous androgen by Lawson Wilkins in 1957; androgen receptor mutations were reported in 1989. Steroidogenic errors were associated with differences in sex development (DSDs) starting in the 1940s, and finding mutations in the responsible enzymes explained many forms of hyper- and hypo-androgenism in both sexes. Sex chromosomes were identified in the early 20th century; Y was associated with maleness, and the responsible <i>SRY</i> gene was identified in 1991. Early efforts to manage patients with DSDs were confounded by philosophical perspectives on the relative roles of prenatal biology versus postnatal environment. Approaches to natal sex assignment evolved in the later 20th century and now emphasize a team approach based on data, not guessing, parental involvement, cultural considerations, and the acknowledgement of uncertainty.

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“…Oluf Thomsen of Copenhagen described new blood group subdivisions (Thomsen ) that gave rise to a correspondence and subsequent contributions. Pettersson and Bonnier's () record of an inherited human sex mosaic was criticized by Solomon G. Levit (Levit , Bonnier ). The latter, a distinguished Soviet specialist of children's diseases, was soon thereafter shot as a traitor by the henchmen of Trofim D. Lysenko in the name of proletarian biology (Bengtsson ).…”

Section: Nilsson's Evidence In 1921mentioning

confidence: 99%

A tale of two papers

Saura

2014

Hereditas

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Two papers published in HEREDITAS between 1921 and1939 show how the attitude towards race biology changed in the course of the interwar period in the Nordic countries. In the early 1920s race biology was seen to constitute a legitimate science. Ordinary human genetics prevailed, however, over race biology already in the very beginning on the pages of HEREDITAS. Population thinking was introduced into the study of human heredity around the year 1930. It effectively contradicted the concept of the race. Interestingly, HEREDITAS does not carry a single paper on eugenics and sterilization. In 1939 we see a fi nal repudiation of the doctrines on race. Times had changed and the National Socialists had usurped the doctrines of race in Germany.

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Inherited Sex-Mosaic in Man

Cited by 57 publications

References 12 publications

A rare case report - Ovary attached to testicle inside hernia sac

A rare case report - Ovary attached to testicle inside hernia sac

The Long Path to Our Current Understanding Regarding Care of Children with Differences/Disorders of Sexual Development

A tale of two papers

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