Inherited or acquired metabolic disorders

West Nile virus encephalomyelitis in an immunocompromised patient

“…The lesions observed on MRI in our case primarily involved white matter structures (eg, cerebral peduncles, dorsal pons, and dorsal medulla), but also, to an extent, deep gray matter structures, particularly the thalamus. This pattern can be seen acutely in multiple neurologic disorders and could be generally referred to as “acute leukoencephalopathy.” Acute leukoencephalopathies are associated with often symmetric white matter lesions that can be either transient (such as in our case) or progressive [23] , but gray matter structures are often affected to a much lesser degree. In the remainder of this section, we will discuss relatively common disorders presenting with acute leukoencephalopathy from a neuroimaging perspective.…”

Metabolische und toxische Enzephalopathien, Teil 1

“…Auch die Trennung metabolisch versus toxisch ist unscharf: So kann man die hepatische Enzephalopathie neben ihrer metabolischen Zuordnung auch als "endogen" toxische Enzephalopathie ansehen, während exogen toxische Enzephalopathien durch Genussgifte, Drogen oder primär toxische Substanzen verursacht werden. Manche Organdysfunktionen können auf unterschiedliche Weise zur Enzephalopathie beitragen wie beispielsweise bei einer Zöliakie durch sowohl autoimmunologische Mechanismen als auch durch intestinale Resorptionsstörungen [5][6][7][8].…”

Stem Cell Research Tools in Human Metabolic Disorders: An Overview

“…Disorders of metabolism are very common in the population worldwide [2] and are among the diseases with the highest health utilization and costs per person [3]. Generally, these disorders are classified into two main groups: acquired and inherited [4]. Acquired metabolic diseases, such as diabetes mellitus or obesity, are linked to different external factors, such as an unhealthy lifestyle along with reduced physical exercise and high caloric intake [4].…”

“…Generally, these disorders are classified into two main groups: acquired and inherited [4]. Acquired metabolic diseases, such as diabetes mellitus or obesity, are linked to different external factors, such as an unhealthy lifestyle along with reduced physical exercise and high caloric intake [4]. Differently, inherited metabolic disorders, such as lysosomal storage diseases (LSDs), and peroxisomal and metal metabolism diseases, are caused by inborn errors of metabolism resulting from genetic defects [4].…”

“…Acquired metabolic diseases, such as diabetes mellitus or obesity, are linked to different external factors, such as an unhealthy lifestyle along with reduced physical exercise and high caloric intake [4]. Differently, inherited metabolic disorders, such as lysosomal storage diseases (LSDs), and peroxisomal and metal metabolism diseases, are caused by inborn errors of metabolism resulting from genetic defects [4]. While clinical trials are in progress for possible treatments for some of these diseases, there is currently no approved therapy for many of them, resulting in a huge economic hit and tension for society [5].…”