Inherited disorders of hemoglobin synthesis and pregnancy

Perkins, Richard P.

doi:10.1016/0002-9378(71)90938-0

Cited by 49 publications

(14 citation statements)

References 83 publications

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“…From this series, it would appear that there is no increase in obstetrical hazards in /3-thalassaemia minor and this supports the findings of Hocking and Ibbotson (1966) and Perkins (1971). Fleming and Lynch (1969) found an increase in the incidence of fetal distress.…”

Section: Discussionsupporting

confidence: 75%

Folic Acid in the Management of Β‐thalassaemia Minor During Pregnancy

Hegde

Khunda

1974

BJOG

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Haematological and obstetrical data were collected from 32 pregnant women with ,8-thalassaemia minor. Twenty of these were given folate supplements throughout pregnancy; the remainder did not receive folic acid. Folic acid did not affect the course of anaemia and there was no statistical difference in the haematological parameters in the two groups, both in the antenatal and the immediate postnatal period. There was no excess of obstetrical complications in either of the two groups.

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Section: Discussionsupporting

confidence: 75%

Folic Acid in the Management of Β‐thalassaemia Minor During Pregnancy

Hegde

Khunda

1974

BJOG

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“…Many haemoglobinopathies are now known but they do not all influence fetal growth (Hendrickse et al, 1972a and b), neither do they all cause severe anaemia. In fact, only mothers with sickle cell anaemia, who are also the most anaemic, bear a large proportion of low birthweight babies (Perkins, 1971 ;Hendrickse et al, 1972a;Anderson et al, 1960). The factors responsible for this retardation of intrauterine growth in sickle cell anaemia have not been easy to identify (Anderson et al, 1960) although chronic ill-health must play some part.…”

Section: Discussionmentioning

confidence: 91%

Maternal Anaemia and Fetal Birthweight

Harrison

Ibeziako

1973

BJOG

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Summary The pattern of fetal birthweight distribution was examined in singleton babies bora to several groups of pregnant Nigerian women: 43 of them were anaemic throughout pregnancy and also at delivery; 142 had been successfully treated for anaemia during pregnancy; 35 had sickle‐cell anaemia; and 65 served as healthy controls. The causes of anaemia were haemolysis from malaria, folate deficiency and haemoglobinopathies. When other factors known to reduce fetal birthweight were excluded, it was found that maternal anaemia (haematocrit less than 30 per cent) was itself associated with retardation of fetal growth and that this was most marked in the presence of sickle‐cell anaemia. If, at the end of pregnancy, maternal anaemia still remained uncorrected, then a 2 per cent drop in maternal haematocrit reduced fetal birthweight by about 100 g.

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“…Endocrine impairment is well recorded in transfusion‐dependent patients with thalassaemia major and is thought to be due to the deleterious effects of excessive iron deposition in endocrine and other organs following multiple blood transfusions (Wonke & De Sanctis 1992). In the 1960s it was believed unlikely that patients with thalassaemia major could ever reproduce (Bannerman 1961; Zaino & Dolan 1966), but since then there have been several cases reported of successful pregnancies in transfusion‐dependent thalassaemic patients with a total of 15 pregnancies in 10 women reported (Walker et al 1969; Perkins 1971; Thomas & Skalioka 1980; Goldfarb et al 1982; Martin 1983; Meadows 1984; Grech et al 1984; Mordel et al 1989; Savona‐Ventura & Grech 1991; Savona‐Ventura & Bonello 1994). In addition, two centres in Italy have had 10 pregnancies in six women, five of whom required ovulation induction (V. De Sanctis 1994, personal communication).…”

mentioning

confidence: 99%

Fertility in β thalassaemia major: a report of 16 pregnancies, preconceptual evaluation and a review of the literature

Jensen

Tuck

Wonke

1995

BJOG

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Objectives To examine the pregnancies, mode of delivery and outcomes, review the literature on fertility and discuss preconceptual guidance for women with β thalassaemia major. Design An observational study. Subjects Sixteen women with p thalassaemia major. Setting Two collaborating London teaching hospitals. Main outcome measures Pre‐pregnancy assessment, pregnancy course, mode of delivery, gesta‐tional age at delivery and birthweight. Results There were 16 pregnancies in 11 women. Three of these pregnancies were terminated. Of the 13 deliveries, there were two normal deliveries, one forceps delivery and 10 caesarean sections. The main findings in a further five women seeking fertility treatment were of hypogonadotrophic hypogonadism, diabetes and cardiomyopathy. Conclusions Pregnancy in women with p thalassaemia major does not appear to have a deleterious effect on the course of the disease. No increased obstetric complications were encountered except for the high caesarean section rate, essentially due to cephalopelvic disproportion. A high incidence of cardiomyopathy and diabetes dictates a careful assessment before embarking on ovulation induction to treat the hypogonadotrophic hypogonadism which is common in these women.

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Inherited disorders of hemoglobin synthesis and pregnancy

Cited by 49 publications

References 83 publications

Folic Acid in the Management of Β‐thalassaemia Minor During Pregnancy

Folic Acid in the Management of Β‐thalassaemia Minor During Pregnancy

Maternal Anaemia and Fetal Birthweight

Fertility in β thalassaemia major: a report of 16 pregnancies, preconceptual evaluation and a review of the literature

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