Inherited Disorders of Bilirubin Metabolism

Roy‐Chowdhury, Namita; Guha, Chandan; Roy‐Chowdhury, Jayanta

doi:10.1007/978-3-030-67727-5_58

Cited by 2 publications

(3 citation statements)

References 42 publications

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“…A separate paragraph is needed to consider BR and BV interactions with human serum albumin (HSA), not only because it was the first system in which optical activity was observed [ 64 ], but also because of the biological/medical implications [ 24 ], serum albumin being the principal transport protein [ 81 , 85 , 86 , 87 , 88 ]. BR and BV have been considered also in interaction with enzymes such that characterization can also be followed, taking advantage of chiroptical techniques [ 89 , 90 ].…”

Section: Deracemization With Chiral Agentsmentioning

confidence: 99%

“…Surprisingly, even after the Z -stereochemistry of the pigments in solution became firmly established by spectroscopy [ 1 , 2 ], the E continued to be designated without Lemberg’s qualification and propagated in published work [ 20 , 21 , 22 , 23 ]. Yet, experimental assignment of the exocyclic carbon–carbon double bonds of BR is of absolute importance to understanding its physico-chemical properties and metabolism [ 24 , 25 ].…”

Section: Introduction and Historical Notementioning

confidence: 99%

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Insights into the Structures of Bilirubin and Biliverdin from Vibrational and Electronic Circular Dichroism: History and Perspectives

et al. 2023

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In this work we review research activities on a few of the most relevant structural aspects of bilirubin (BR) and biliverdin (BV). Special attention is paid to the exocyclic C=C bonds being in mostly Z rather than E configurations, and to the overall conformation being essentially different for BR and BV due to the presence or absence of the double C=C bond at C-10. In both cases, racemic mixtures of each compound of either M or P configuration are present in achiral solutions; however, imbalance between the two configurations may be easily achieved. In particular, results based on chiroptical spectroscopies, both electronic and vibrational circular dichroism (ECD and VCD) methods, are presented for chirally derivatized BR and BV molecules. Finally, we review deracemization experiments monitored with ECD data from our lab for BR in the presence of serum albumin and anesthetic compounds.

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Section: Deracemization With Chiral Agentsmentioning

confidence: 99%

Section: Introduction and Historical Notementioning

confidence: 99%

Insights into the Structures of Bilirubin and Biliverdin from Vibrational and Electronic Circular Dichroism: History and Perspectives

et al. 2023

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“…Developmentally, bilirubin transferase is often delayed. As a consequence, neonates are often exposed to episodes of high serum bilirubin concentrations that may lead to deposits in the central nervous system and cause kernicterus (neurotoxicity) (1). This occurrence is a major concern for neonatologists and clinicians because of the possibility for permanent damage to the central nervous system of neonates.…”

mentioning

confidence: 99%