“…Neurologic dysfunction in SCA12 appears to progress more slowly than in MSA (Wenning et al, 1994) so that many SCA12 patients remain employed and independent in their sixth and seventh decades. SCA12 is distinguished as the only SCA in which action tremor is the most common and earliest sign, although an action tremor may also be seen in patients with other inherited ataxias, including FXTAS, DRPLA, SCA2, SCA3, SCA6, SCA8, SCA14, SCA16, SCA19, SCA21, and SCA27 (Brusse et al, 2006;O'Hearn, 2006b). Since SCA12 is an inherited disorder, the diagnosis should be considered in any patient with action tremor plus a family history of tremor combined with other neurologic or psychiatric signs or symptoms.…”