Inheritance of high blood pressure

Pickering, George

doi:10.1007/978-3-642-49899-2_2

Cited by 40 publications

(40 citation statements)

References 2 publications

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“…Para Platt a hipertensão arterial seria uma entidade mórbida, de caráter qualitativo, que se manifesta em pessoas de meiaidade com uma carga genética específica, através de um gen único ou, pelo menos, poucos gens 20 . Já, para Pickering, a hipertensão arterial é um desvio quantitativo da norma, sendo que a pressão arterial é uma característica cuja distribuição se aproxima a uma curva normal, em qualquer população, denotando assim a influência de uma hereditariedade multifatorial, poligênica 19 . Estudos com grupos de pessoas relacionadas geneticamente, em domicílios, mostraram que há agregação familiar de pressão arterial, porém fraca e de interpretação duvidosa, uma vez que indivíduos que moram num mesmo domicílio também compartilham entre si uma série de experiências ambientais 22 » 24 .…”

Section: Resultados E Comentários A) Fumounclassified

Fumo, bebida alcoólica, migração, instrução, ocupação, agregação familiar e pressão arterial em Volta Redonda, Rio de Janeiro

Klein

Araújo

1985

Cad. Saúde Pública

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Section: Resultados E Comentários A) Fumounclassified

Fumo, bebida alcoólica, migração, instrução, ocupação, agregação familiar e pressão arterial em Volta Redonda, Rio de Janeiro

Klein

Araújo

1985

Cad. Saúde Pública

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“…In the control period, the plasma renin activity was 20.79 ± 4.46 (SD) ng/ml hour" 1 . At the fourth week there was a dramatic and significant (P < 0.01) reduction in renin to 0.33 ± 0.02 ng/ml hour" 1 …”

Section: Plasma Renin Activitymentioning

confidence: 94%

“…These changes have traditionally been considered to be the consequence of the mechanical stress of excessive filling pressure imposed on the overstimulated arterial muscular wall (1).…”

mentioning

confidence: 99%

Malignant hypertension resulting from deoxycorticosterone acetate and salt excess: role of renin and sodium in vascular changes.

Gavras¹,

Brunner²,

Laragh³

et al. 1975

Circulation Research

189

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The evolution of malignant hypertension was studied under metabolic balance conditions in 11 uninephrectomized rats given deoxycorticosterone acetate and 1% NaCl as drinking water. Changes in sodium and potassium balance were related to changes in blood pressure, plasma renin activity, hematocrit, and kidney histology. After 3-4 weeks of steadily positive sodium balance accompanied by continuously increasing blood pressure up to 185 ± 19 (SE) mm Hg, periods of sodium loss accompanied by evidence of hemoconcentration were observed marking the onset of the malignant phase as defined by the development of fibrinoid necrosis in the kidney. Plasma renin activity remained markedly suppressed both at the fourth week (0.33 ± 0.02 ng/ml hour" 1 ) when the sodium balance was positive and the kidney biopsy negative and at the end of the experiment (0.35 ± 0.36 ng/ml hour" 1 ) when the sodium balance was negative and the kidney histology revealed malignant vasculitis. Infusion of the angiotensin II inhibitor l-Sar-8-Ala-angiotensin II consistently failed to affect blood pressure, and the kidney tissue norepinephrine level was reduced (0.054 ± 0.01 /^g/g) compared with the control level (0.132 ± 0.02 Mg/g). We conclude that malignant vasculitis in this model is preceded by hypertension associated with sodium and water retention and is accompanied by negative sodium balance, decreases in body weight, falling blood pressure, and hemoconcentration without demonstrable participation of the renin-angiotensin system or the renal catecholamines. KEY WORDS hemoconcentration Wistar ratsangiotensin II inhibitor metabolic balance fibrinoid lesions plasma renin activity• Malignant hypertension has classically been distinguished pathologically from benign essential hypertension by the presence of extensive fibrinoid necrosis of terminal arteries and arterioles as well as proliferative endarteritis. These changes have traditionally been considered to be the consequence of the mechanical stress of excessive filling pressure imposed on the overstimulated arterial muscular wall (1).In human malignant hypertension, aldosterone secretion rates have often been found to be elevated (2). This observation has led to the finding that angiotensin controls aldosterone secretion (3) and to the hypothesis that renin is critically involved in the syndrome of malignant hypertension (4). This thesis has been supported by clinical observations (5) and by animal experiments in

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“…It is uncrtain, however, whether their mechanism of hypotensive action remains constant during long-term use. It has been shown that the mechanism of sustained hypertension changes with time in the clipped rat (Ledingham & Cohen, 1964;Langston, Guyton, Douglas & Dorsett, 1963;Guyton, Coleman, Fourcade & Navar, 1968) and in man (Pickering, 1968) as does the mechanism of sustained oedema in the nephrotic syndrome (Vere, 1971). It is therefore reasonable to ask similar questions about sustained reductions in blood pressure induced by drugs in human hypertension.…”

Section: Inhtroducionmentioning

confidence: 99%

A longitudinal study of the mechanisms of action of debrisoquine and propranolol.

Aminu¹,

Vere²

1978

Brit J Clinical Pharma

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1 The mode of action of hypotensive drugs is not necessarily the same early and late in a course of treatment. 2 It was aimed to study this possible difference of effects for the drugs debrisoquine and propranolol, using a clinical trial design and measuring as many cardiovascular functions as possible by noninvasive methods in out‐ patients. 3 Several well known effects of these drugs were noted; in addition it was found that in some subjects there was a small but progressive salt retention during propranolol treatment, that the displacements of the slopes in baroceptor function tests were different for the two drugs tested, and that venous distensibility was reduced at first with propranolol but soon increased again. 4 It is useful to combine longitudinal measures of body functions with a clinical trial when studying mechanisms of drug action.

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Inheritance of high blood pressure

Cited by 40 publications

References 2 publications

Fumo, bebida alcoólica, migração, instrução, ocupação, agregação familiar e pressão arterial em Volta Redonda, Rio de Janeiro

Fumo, bebida alcoólica, migração, instrução, ocupação, agregação familiar e pressão arterial em Volta Redonda, Rio de Janeiro

Malignant hypertension resulting from deoxycorticosterone acetate and salt excess: role of renin and sodium in vascular changes.

A longitudinal study of the mechanisms of action of debrisoquine and propranolol.

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