Inheritance of dermoid sinus in the Rhodesian ridgeback

Hillbertz, N. H. C. Salmon

doi:10.1111/j.1748-5827.2005.tb00295.x

Cited by 24 publications

(23 citation statements)

References 8 publications

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“…However, some authors recently proposed that a distinction should be made in dogs and cats, as it is done in humans, between dermoid cysts and DSes based on the presence in the latter of a connection to the skin [4,27,56,57]. Similarly, other authors identified different types of DS in dogs and considered dermoid cyst as a specific type of DS lacking an opening on the skin [19,26,35,55].…”

Section: Discussionmentioning

confidence: 99%

“…Later, two other types of DS, type V [16] and type VI [32], were introduced. Type V was described as a true dermoid cyst consisting of a closed epithelial-lined sac difficult to detect via palpation of the skin [57]. This can be considered a more accurate use of the term ‘dermoid cyst’ since fistulous tract formation or connection to the epidermis is absent.…”

Section: Discussionmentioning

confidence: 99%

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Multiple dermoid sinuses of type Vb and IIIb on the head of a Saint Bernard dog

et al. 2013

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Dermoid sinus, a congenital malformation of neural tube development, has been reported in humans and several animal species including dogs. It is typically found in the dorsal midline and commonly occurs in the Rhodesian Ridgeback breed. A case of multiple dermoid sinuses in the fronto-occipital region is described. An 11-month-old, intact female Saint Bernard dog was presented with a 2 day history of discharge from a large irregular subcutaneous mass in the fronto-occipital region. The dog was otherwise healthy. The dog had two circular skin lesions (approximately 4 × 4 and 4 × 2 cm diameter) surrounded by multiple irregular elevated masses. The masses had multiple small openings on the skin surface with tufts of hair protruding from the apertures. The masses were surgically removed, and the diagnosis of multiple dermoid sinuses was confirmed by histological examination. Histopathological examination showed multiple, variably sized, spherical to tubular cysts expanding the dermis and subcutis. Cysts were filled with hair shafts and lamellar keratin and were lined by a stratified squamous epithelium. Sebaceous and apocrine gland adnexal structures were also observed. To the best of our knowledge, this is the first reported case of multiple dermoid sinuses of two different types in the head of a Saint Bernard dog.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Multiple dermoid sinuses of type Vb and IIIb on the head of a Saint Bernard dog

et al. 2013

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“…[11] The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. The causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes.…”

Section: Breed Historymentioning

confidence: 99%

“…FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development. [11] An important sign to recognize a true Phu Quoc dog is the sword shaped ridge on its back, together with short, thin hair. When facing competitors or running after prey, the hair on their back becomes erect, creating a ridge making the dog look brave and strong.…”

Section: Breed Historymentioning

confidence: 99%

Initially Observed Some Important Morphological Characteristics on Phu Quoc Ridgeback Dogs (Canis familiaris) in Vietnam

2016

IJSR

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“…spina bifida, spinous process malformations, hemivertebrae, and block vertebrae) may be associated with congenital intracranial or spinal dermoid sinus [6,12,14-18]. Vertebral anomalies associated with limbs malformations are rare in small animals [19,20].…”

Section: Introductionmentioning

confidence: 99%

Spinal dermoid sinus in a Dachshund with vertebral and thoracic limb malformations

et al. 2014

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BackgroundDermoid sinus is an uncommon epithelial-lined fistula that may be associated with vertebral malformations. In humans, Klippel-Feil syndrome (KFS) is a rare condition characterized by congenital cervical vertebral fusion and may be associated with other developmental defects, including dermoid sinus. The present case report describes an adult Dachshund with cervical and cranial thoracic vertebral malformations as well as thoracic limb malformations resembling KFS with a concurrent type IV dermoid sinus.Case presentationA 1.5 year-old Dachshund with congenital thoracic limbs deformities and cervical-thoracic vertebral malformations presented with cervical hyperesthesia, rigidity of the cervical musculature and tetraparesis. Neurologic, radiographic, and computed tomography (CT) (2D, 3D, CT fistulography) examinations revealed skeletal anomalies, a dermoid sinus in the cranial thoracic region and epidural gas within the vertebral canal. Surgical resection and histopathological evaluation of the sinus tract were performed and confirmed a type IV dermoid sinus. The clinical signs progressively recovered postoperatively, and no recurrent signs were observed after 6 months of follow-up.ConclusionsCervical vertebral malformations associated with limbs anomalies have not been reported in dogs and may represent a condition similar to KFS in humans. KFS can occur concurrently with other congenital conditions including dermoid sinus and should be included among the complex congenital anomalies described in dogs.

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Inheritance of dermoid sinus in the Rhodesian ridgeback

Abstract: Bias in heredity pattern may be caused by undetected dermoid sinus type V. Improved clinical diagnosis of all dermoid sinus types is therefore crucial.

Cited by 24 publications

References 8 publications

Multiple dermoid sinuses of type Vb and IIIb on the head of a Saint Bernard dog

Multiple dermoid sinuses of type Vb and IIIb on the head of a Saint Bernard dog

Initially Observed Some Important Morphological Characteristics on Phu Quoc Ridgeback Dogs (Canis familiaris) in Vietnam

Spinal dermoid sinus in a Dachshund with vertebral and thoracic limb malformations

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