Inheritance of abnormal erythrocyte cation transport in essential hypertension.

Meyer, Philippe; Garay, Ricardo P.; Nazaret, Corinne; Dagher, Georges; Bellet, M; Broyer, M.; Feingold, J

doi:10.1136/bmj.282.6270.1114

Cited by 66 publications

(17 citation statements)

References 12 publications

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“…The levels of SLC activity observed in this study for hypertensives is higher than was observed for blacks in previous studies in the West [16][17][18] but is only slightly lower than the values that have generally been obtained for Caucasians. 4,17 The finding that SLC activity is reasonably comparable to the reported Caucasian levels is in line with a previous report by Woods et al 13 These authors also confirmed at follow-up 15 that no race differences existed in SLC activity in their series. Recently, Hardman et al 23 also showed that the changes in behaviour of SLC related to hypertension were the same in all ethnic groups using kinetic studies.…”

Section: Discussionsupporting

confidence: 81%

“…Although abnormally increased SLC activity has been described by many observers among Caucasians, 4,[10][11][12][13] this increase in activity has not been seen in much of the work in black subjects. [15][16][17] Some reports indicate that the increase in SLC activity is either reduced 16 or does not occur in black subjects; 15,17 suggesting that this mechanism is not important in the pathogenesis of hypertension in black people.…”

Section: Discussionmentioning

confidence: 99%

“…In support of this there have been various descriptions of abnormalities of sodium transport across cell membranes in hypertensive patients. [3][4][5][6][7][8] There is now a body of evidence suggesting that sodium-lithium countertransport (SLC) abnormality in erythrocytes is associated with hypertension, as well as a predisposition to its development in Caucasians, 5,[9][10][11][12] that it aggregates in families 9,13,14 and that it is strongly influenced by genetic factors. 9,[13][14][15] Racial differences have been described in erythrocyte cation transport and it is thought that these changes are either reduced or may not occur in nonwhite persons, especially blacks.…”

Section: Introductionmentioning

confidence: 99%

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Sodium-lithium countertransport activity in normotensive offspring of hypertensive black Africans

1998

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Objective: To assess sodium-lithium countertransport (SLC) activity and erythrocyte sodium (ENa) levels in black (Nigerian) hypertensive (HT) patients, normotensive (NT) offspring of hypertensive parents and normotensive offspring of normotensive parents, and to determine if increased SLC activity is related to a familial predisposition to hypertension in black subjects as in Caucasians. Method: The study was done using 60 Nigerian subjects of Edo ethnic origin in three groups of 20 each: (a) untreated new HT patients at the University Teaching Hospital, Benin City; (b) NT children of hypertensive parents (NTHT) traced home and matched for age, sex and body mass index (BMI) with (c) NT children of NT parents (NTNT). SLC activity was measured using a modified method of Canessa et al 1980 and ENa assessed by flame photometry. Results: SLC was markedly higher in both HT patients

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sodium-lithium countertransport activity in normotensive offspring of hypertensive black Africans

1998

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“…1 " 4 The abnormality concerning different mechanisms of sodium transport, has been also detected in normotensive people born to parents with essential hypertension: 5 ' 6 it could have a predictive value for a later hypertensive disease. One of the cation transport mechanisms that has been found abnormal in the erythrocytes of patients with essential hypertension is the Li r Na o countertransport, 2 6 albeit a consistent overlap of the values of the countertransport between the normotensive and hypertensive groups has been further reported by several authors.…”

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confidence: 99%

Lithium-sodium countertransport in erythrocytes of normal and hypertensive subjects. Relationship with age and plasma renin activity.

Brugnara¹,

Corrocher²,

Foroni³

et al. 1983

Hypertension

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SUMMARY Li,-Na a countertransport was measured in red blood cells of 58 normotensive subjects (27 females and 31 males), 60 patients with essential hypertension (26 females and 34 males), and in 28 with secondary hypertension (19 females and 9 males). The mean values (± SEM) expressed as mmol Li (1 red cells x hr)" 1 were 0.18 ± 0.02 (females) and 0.20 ± 0.01 (males) in the control group, 0.34 ± 0.04 (females) and 0.39 ± 0.03 (males) in essential hypertension, 0.16 ± 0.03 (females) and 0.19 ± 0.02 (males) in secondary hypertension. The mean value of Li,-Na o countertransport obtained in essential hypertension was statistically different from those obtained in both normals (p < 0.001) and patients with secondary hypertension (p < 0.001). A negative correlation was found between age and Li | -Na o countertransport in normotensive males (r = -0.648; p < 0.001) but neither in normal females nor in patients with essential hypertension. A positive correlation (r = + 0.425; p < 0.05) was found between plasma renin activity after intravenous furosemide and Ll-Na countertransport in essential hypertension. These findings support the hypothesis of a characteristic cation transport across the red blood cell membrane of patient with essential hypertension which might be correlated with the plasma renin activity. (Hypertension 5:529-534, 1983) KEY WORDS •• erythrocyte countertransport • age • plasma renin activity • hypertension A N altered cation transport in red blood cells of essential hypertensive subjects has often been observed and has been sometimes referred to as a useful test differentiating essential from secondary hypertension.1 " 4 The abnormality concerning different mechanisms of sodium transport, has been also detected in normotensive people born to parents with essential hypertension:5 ' 6 it could have a predictive value for a later hypertensive disease. One of the cation transport mechanisms that has been found abnormal in the erythrocytes of patients with essential hypertension is the Li r Na o countertransport, 2 6 albeit a consistent overlap of the values of the countertransport between the normotensive and hypertensive groups has been further reported by several authors. -7 8The aim of the present study was to correlate the Li r Na 0 countertransport in the red blood cells of normotensive and hypertensive people with other clinical and biochemical parameters usually investigated in these subjects and particularly with the plasma renin activityF Methods Selected for study were 58 (27 females and 31 males) normotensives, 60 patients (26 females and 34 males) with essential hypertension, and 28 patients (19 females and 9 males) with secondary hypertension. The mean age of the three groups of patients was 38 ± 15, 46 ± 11, and 41 ± 16 years respectively. Among secondary hypertensives, 13 had hypertension secondary to kidney disease, eight had hyperaldosteronism (6 hyperplasia and 2 adenoma), four had polycystic kidney disease, and three had renovascular hypertension. All patients were untreated for at le...

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“…- 18 Meyer et al 22 proposed that a sodium and potassium cotransport pathway defect was inherited and a single gene mechanism was involved.…”

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confidence: 99%

Race, sex, and family history of hypertension and erythrocyte sodium pump [3H]ouabain binding.

1990

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We studied the binding properties of [ 3 H]ouabain to erythrocytes from normotensive children (n=83) between the ages of 10 and 18 years (mean resting arterial pressure: 102/57 mm Hg) from normotensive and essential hypertensive parents. Arterial blood pressures of 101/57 and 104/57 mm Hg (subjects with normotensive and hypertensive parents, respectively) were not significantly different between the two groups. Forty-four children had normotensive parents and 39 had hypertensive parents, 51 were white and 32 were black, and 41 were girls and 42 were boys. By using the [ 3 H]ouabain-binding technique, we determined the density of sodium pump sites and the equilibrium dissociation constants in erythrocytes from these children. Possible effects of race, sex, or parental hypertension status on pump sites and dissociation constants were tested with a three-way analysis of variance (ANOVA). Race had a major effect on the dissociation constant: blacks had a significantly higher value than did whites (p=0.002). We also found a race by sex by parental hypertension status interaction (p=0.04) with black girls with hypertensive parents having the highest value. There was no effect of race, sex, or status on sodium pump site density. Age, height, weight, resting arterial blood pressure, and plasma Na + and K + concentrations did not correlate with the dissociation constants. These data suggest that, among the groups we studied, black girls with hypertensive parents had erythrocytes with the lowest binding affinity for ouabain. In addition, race had a strong effect on the binding affinity of ouabain to human erythrocytes, with blacks having lower affinities than whites. Because the black population has a much higher prevalence of hypertension than the white population and black women have the highest prevalence of hypertension, this decrease in the affinity of ouabain-binding to the erythrocyte sodium pump molecule may be a possible predictor of adult hypertension. (Hypertension 1990;15:146- Parts of this study were presented at the 60th Scientific Sessions of the American Heart Association in Anaheim, California, November 16-19, 1987. Supported by research grants HL-35788 and HL-32270 from the National Institutes of Health and a Grant-in-Aid from the American Heart Association, Tennessee Affiliate.Address for correspondence: Dr. Emel Songu-Mize, Department of Pharmacology, University of Tennessee, Memphis, 874 Union Ave., Rm 100, Memphis, TN 38163.Received September 20,1988; accepted in revised form October 13, 1989. transport pathways in other tissues, such as the vasculature, have also been noted in some animal models of hypertension. 13- 16 In some reports, normotensive offspring of hypertensive individuals manifested some of these sodium transport abnormalities. -1718 In spite of extensive knowledge related to cation transport in hypertensive persons, findings related to ouabain-sensitive or the sodium pumpdriven transport system are less definitive than findings for other transport systems. Moreover, binding prop...

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Inheritance of abnormal erythrocyte cation transport in essential hypertension.

Cited by 66 publications

References 12 publications

Sodium-lithium countertransport activity in normotensive offspring of hypertensive black Africans

Sodium-lithium countertransport activity in normotensive offspring of hypertensive black Africans

Lithium-sodium countertransport in erythrocytes of normal and hypertensive subjects. Relationship with age and plasma renin activity.

Race, sex, and family history of hypertension and erythrocyte sodium pump [3H]ouabain binding.

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