Inheritance and Properties of the Antigen MuBl and its Relation to Hæmolytic Complement

Cinader, B.; Dubiski, S.; Wardlaw, A. C.

doi:10.1038/205097a0

Cited by 21 publications

(29 citation statements)

References 9 publications

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“…Male mice are known to have higher serum concentrations of C5 than females (15,16), and this observation was confirmed for both BALB/c and CBA/H strains ( Table 1). The difference in C5 concentration between males and females from BALB/c mice was similar to that reported previously (16), providing further evidence for the specificity of the goat anti-mouse C5.…”

Section: Resultssupporting

confidence: 54%

“…The same antibody failed to react with serum from A/J, AKR and DBA/2 mice. The former and latter groups of mouse strains have been shown previously to be C5 sufficient and C5 deficient, respectively (16).…”

Section: Methodsmentioning

confidence: 99%

“…molytic activity and serum concentrations of C5 are different in male and female mice (15,16). We therefore sought to determine whether there was any correlation between the severity of tissue lesions and the serum concentrations of C3 orC5 in male and female mice of susceptible and resistant strains.…”

Section: Introductionmentioning

confidence: 99%

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Murine candidiasis: Sex differences in the severity of tissue lesions are not associated with levels of serum C3 and C5

Ashman

Kay

Lynch

et al. 1991

Immunology & Cell Biology

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Summary Mice deficient in the fifth component of complement are known to be extremely susceptible to lethal challenge with Candida albicans. However, male mice, that have significantly higher concentrations of serum C5 than females, were markedly more susceptible to infection. This difference was observed in both susceptible (CBA/H) and resistant (BALB/c) mice. Levels of serum C3 likewise showed no correlation with susceptibility.

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Section: Resultssupporting

confidence: 54%

Section: Methodsmentioning

confidence: 99%

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Murine candidiasis: Sex differences in the severity of tissue lesions are not associated with levels of serum C3 and C5

Ashman

Kay

Lynch

et al. 1991

Immunology & Cell Biology

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“…There are inbred strains of rabbits with C'6 deficiency (4, 5), of mice with C'5 deficiency (6,7), and a strain of guinea pigs deficient in one of the proteins comprising the classical third component of complement (8,9). C'2 deficiency has now been well characterized in at least two families (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Inherited deficiency of the third component of human complement (C′3)

Alper¹,

Propp²,

Klemperer³

et al. 1969

J. Clin. Invest.

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“…The activities of several complement components in mice are higher in males than in females [1,2,12]. Female protein (FP) in Syrian hamsters [3] and sex influenced esterase (ESSI) in rats [4] are hardly detectable in the normal mature males.…”

mentioning

confidence: 99%

Re-examination on the Sex-influenced Esterase (ESSI) in Rat Serum

Nikaido

Hayakawa

1989

Experimental Animals

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The sex-limitation of sex-influenced esterase (ESSI) in serum of rats carrying Es-Sia allele was re-examined.ESSI was detected in immature males and females, and orchiectomized rats as well as mature females whereas ESSI in normal males rapidly disappeared with puberty. The rats orchiectomized at weaning temporarily lost ESSI around the age of sexual maturation, thereafter, ESSI reappeared. When orchiectomized rats were administered testosterone, synthesis of ESSI was suppressed as in normal adult males.Effect of ovariectomy was not recognized. The exceptional strain named SI 3 of which normal mature males have a significan tlevel of ESSI has been established, although the level in the males is lower than that in the females of the same strain.

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Inheritance and Properties of the Antigen MuBl and its Relation to Hæmolytic Complement

Cited by 21 publications

References 9 publications

Murine candidiasis: Sex differences in the severity of tissue lesions are not associated with levels of serum C3 and C5

Murine candidiasis: Sex differences in the severity of tissue lesions are not associated with levels of serum C3 and C5

Inherited deficiency of the third component of human complement (C′3)

Re-examination on the Sex-influenced Esterase (ESSI) in Rat Serum

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