2009
DOI: 10.1152/ajpcell.00608.2008
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Inherent differences in morphology, proliferation, and migration in saphenous vein smooth muscle cells cultured from nondiabetic and Type 2 diabetic patients

Abstract: Madi HA, Riches K, Warburton P, O'Regan DJ, Turner NA, Porter KE. Inherent differences in morphology, proliferation, and migration in saphenous vein smooth muscle cells cultured from nondiabetic and Type 2 diabetic patients. Am J Physiol Cell Physiol 297: C1307-C1317, 2009. First published September 9, 2009 doi:10.1152/ajpcell.00608.2008.-Individuals with Type 2 diabetes mellitus (T2DM) are at increased risk of saphenous vein (SV) graft stenosis following coronary artery bypass. Graft stenosis is caused by in… Show more

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Cited by 53 publications
(61 citation statements)
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“…A reduced proliferative capacity has been demonstrated in smooth muscle cells isolated from patients with type 2 diabetes (24). In this study, we show that LIF-induced cell proliferation is impaired in myoblasts from patients with type 2 diabetes.…”
Section: Discussionsupporting
confidence: 58%
“…A reduced proliferative capacity has been demonstrated in smooth muscle cells isolated from patients with type 2 diabetes (24). In this study, we show that LIF-induced cell proliferation is impaired in myoblasts from patients with type 2 diabetes.…”
Section: Discussionsupporting
confidence: 58%
“…In the current study, we have extended our morphological characterisation by noting marked aberrations in the F-actin cytoskeleton. Similar F-actin features - i.e., truncated and disorganised fibres - have also been described in SV-SMC from patients with type 2 diabetes (T2DM) [20,21,22]. As both aneurysm disease and T2DM are considered to be conditions characterised by premature aging [23,24], it is feasible that disorganisation of F-actin in SMC is a feature of aged cells rather than representative of a particular disease pathology per se.…”
Section: Discussionmentioning
confidence: 69%
“…For 88 Liu et al, 89 Li et al, 90 Dentelli et al 93 ↓ this reason, it is apparent that identifying the presence of a diabetic metabolic memory might be most accurately observed in EC derived from human diabetic vessels. In such a way, we have previously identified inherent functional differences between vascular SMC cultured from patients with and without T2DM, 107 such data offering an explanation for increased venous bypass graft stenosis after revascularisation surgery in these patients. Identification of any sustained functional differences in T2DM-EC may provide further justification for the aforementioned graft failure.…”
Section: Resultsmentioning
confidence: 84%