Inherent anti-HIV activity of biocompatible anionic citrate-PEG-citrate dendrimer

Kandi, Mohammad Reza; Mohammadnejad, Javad; Ardestani, Mehdi Shafiee; Zabihollahi, Rezvan; Soleymani, Sepehr; Aghasadeghi, Mohammad Reza; Baesi, Kazem

doi:10.1007/s11033-018-4455-6

Cited by 18 publications

(9 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a research conducted by Kandi et al, they measured the inhibitory effect of G2 (a biocompatible anionic citrate-PEG-citrate dendrimer) on HIV infection. The dendrimer exhibited antiviral properties (ICC 50 : 0.4 mM) and minor toxicity (CC 50 : 0.6 mM) [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

In vitro anti-influenza assessment of anionic compounds ascorbate, acetate and citrate

Targhi

Mehrbod

Fotouhi

et al. 2022

Virol J

View full text Add to dashboard Cite

Background Influenza A virus (IAV) infection remains a serious public health threat. Due to drug resistance and side effects of the conventional antiviral drugs, repurposing the available natural compounds with high tolerability and fewer side effects has attracted researchers’ attention. The aim of this study was to screen in vitro anti-influenza activity of three anionic compounds ascorbate, acetate, and citrate. Methods The non-cytotoxic concentration of the compounds was determined by MTT assay and examined for the activity against IAV in simultaneous, pre-, and post-penetration combination treatments over 1 h incubation on Madin-Darby Canine Kidney (MDCK) cell line. The virus titer and viral load were determined using hemagglutination assay (HA) and qPCR, respectively. Few pro-inflammatory and anti-inflammatory cytokines were evaluated at RNA and protein levels by qPCR and ELISA, respectively. Results The non-cytotoxic concentrations of the ascorbate (200 mg/ml), acetate and citrate (both 3 mg/ml) reduced the viral titer by 6.5, 4.5, and 1.5 logs in the simultaneous combination treatment. The M protein gene copy number decreased significantly in simultaneous treatment (P < 0.01). The expression of cytokines was also affected by the treatment of these compounds. Conclusions These anionic compounds could affect the influenza virus load, thereby reducing pro-inflammatory cytokines and increasing anti-inflammatory cytokines levels.

show abstract

Section: Discussionmentioning

confidence: 99%

In vitro anti-influenza assessment of anionic compounds ascorbate, acetate and citrate

Targhi

Mehrbod

Fotouhi

et al. 2022

Virol J

View full text Add to dashboard Cite

show abstract

“…This agrees with previous findings on the effect of anionic citrate-PEG-citrate dendrimers, which showed the strongest anti-HIV activity by G2 dendrimers. 20 Furthermore, G3 sulphated and G2 naphthylsulphonated carbosilane dendrimers were the most effective antivirals against HIV. 21 There were several trials for the development of new therapeutics against MERS-CoV.…”

Section: Plaque Formation Assaymentioning

confidence: 99%

A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus

Kandeel

Al‐Taher

Kim

et al. 2020

Journal of Medical Virology

View full text Add to dashboard Cite

The Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus that causes infection with a potentially fatal outcome. Dendrimers are highly branched molecules that can be added to antiviral preparations to improve their delivery, as well as their intrinsic antiviral activity. Studies on identifying anti-MERS-CoV agents are few. Three types of polyanionic dendrimers comprising the terminal groups sodium carboxylate (generations 1.5, 2.5, 3.5, and 4.5), hydroxyl (generations 2, 3, 4, and 5), and succinamic acid (generations 2, 3, 4, and 5) and polycationic dendrimers containing primary amine (generations 2, 3, 4, and 5) were used to assess their antiviral activity with the MERS-CoV plaque inhibition assay. The hydroxyl polyanionic set showed a 17.36% to 29.75% decrease in MERS-CoV plaque formation. The most potent inhibition of MERS-CoV plaque formation was seen by G (1.5)-16COONa (40.5% inhibition), followed by G(5)-128SA (39.77% inhibition). In contrast, the cationic dendrimers were cytotoxic to Vero cells. Polyanionic dendrimers can be added to antiviral preparations to improve the delivery of antivirals, as well as the intrinsic antiviral activity. K E Y W O R D S antiviral agents, cell cultures, coronavirus, research and analysis methods, virus classification

show abstract

“…CA‐based dendrimers are one member of the dendrimer family with an easy synthesis procedure that opened an effective approach for enhancing the bioavailability and solubility of captured drugs, as well as, improving the therapeutic efficiency. Moreover, it is reported that the CA‐based dendrimers have inherent anti‐HIV activity, antioxidant, and antimicrobial properties 47–49 . In this regard, Valikala et al reported the dendritic formulations of cefotaxime sodium (CFTX) drug for the treatment of bacterial infections.…”

Section: Ca‐based Ddssmentioning

confidence: 99%

“…CA, citric acid; DDS, drug delivery system [Color figure can be viewed at wileyonlinelibrary.com] Moreover, it is reported that the CA-based dendrimers have inherent anti-HIV activity, antioxidant, and antimicrobial properties. [47][48][49] In this regard, Valikala et al reported the dendritic formulations of cefotaxime sodium (CFTX) drug for the treatment of bacterial infections. In the structure of the fabricated system, the polyethylene glycol 600 (PEG 600) was selected as a core and CA as the arm.…”

Section: F I G U R Ementioning

confidence: 99%

Application or function of citric acid in drug delivery platforms

Pooresmaeil

Javanbakht

Namazi

et al. 2021

Medicinal Research Reviews

View full text Add to dashboard Cite

Nontoxic materials with natural origin are promising materials in the designing and preparation of the new drug delivery systems (DDSs). Today's, citric acid (CA) has attracted a great deal of attention because of its special features; green nature, biocompatibility, low price, biodegradability, and commercially available property. So, CA has been employed in the preparation of the various platforms to induce a suitable property on their structure. Recently, several research groups investigated the CA‐based platforms in different forms like tablets, dendrimers, hyperbranched polymers, (co)polymer, hydrogels, and nanoparticles as efficient DDSs. By considering an increasing amount of published articles in this field, for the first time, in this review, an overview of the published works regarding CA applications in the design of various DDSs is presented with a detailed and insightful discussion.

show abstract

Inherent anti-HIV activity of biocompatible anionic citrate-PEG-citrate dendrimer

Cited by 18 publications

References 11 publications

In vitro anti-influenza assessment of anionic compounds ascorbate, acetate and citrate

In vitro anti-influenza assessment of anionic compounds ascorbate, acetate and citrate

A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus

Application or function of citric acid in drug delivery platforms

Contact Info

Product

Resources

About