Inhaled Treatments and the Future of Respiratory Diseases: Holding Our Breath

Traversi, Letizia; Perez-Miranda, Javier; Polverino, Eva

doi:10.1159/000496357

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Studies of targeting probiotics to the lungs demonstrate the effectiveness of probiotics in lung diseases. Intranasal or inhaler probiotic administration can be the preferred treatment option against antibiotic resistance. , The COVID-19 pandemic has led researchers to conduct therapeutic and prophylactic studies directed toward the lungs. Considering the increasing studies on COVID-19 disease, it is thought that using probiotics in high-risk patients and healthcare workers may limit COVID-19 infection .…”

Section: Probiotic Targeting To the Lung And Future Perspectivesmentioning

confidence: 99%

Lung Microbiota: Its Relationship to Respiratory System Diseases and Approaches for Lung-Targeted Probiotic Bacteria Delivery

Yuksel,

Gelmez,

Yildiz-Pekoz

2023

Mol. Pharmaceutics

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Microorganisms that make up the local microbiota (such as Lactobacillus sp. and Bifidobacterium sp.) play a crucial role in the modulation of diseases and health states by taking place not only in the gut but also in many parts of our body. There is also interference between the gut and the lung via the gut–lung axis. The relationship between respiratory diseases and lung microbiota, which become more of an issue of particular importance in recent years, shows that probiotics play an essential role in maintaining the balance of microorganisms in the respiratory tract. However, studies on probiotics’ prophylactic or therapeutic application in chronic lung diseases are limited. In this review, the literature between 1977 and 2022 was surveyed. General information about human microbiota was accessed in earlier sources, and especially in the past decade, research on lung microbiota has been reached. The relationship between lung microbiota and important respiratory diseases such as bronchopulmonary dysplasia, chronic obstructive pulmonary disease, pneumonia, cystic fibrosis, allergy-asthma, influenza, lung cancer, and COVID-19 infection, was scrutinized after mentioning human microbiota, the gut–lung axis, and respiratory tract microbiota. The mechanism of action of probiotics and the formulation approaches of probiotics in terms of pharmaceutical technology were reviewed. Finally, future perspectives on lung-targeted administration of probiotic bacteria with prophylactic or therapeutic potential, or both, were presented.

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Section: Probiotic Targeting To the Lung And Future Perspectivesmentioning

confidence: 99%

Lung Microbiota: Its Relationship to Respiratory System Diseases and Approaches for Lung-Targeted Probiotic Bacteria Delivery

Yuksel,

Gelmez,

Yildiz-Pekoz

2023

Mol. Pharmaceutics

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Probiotic Formulation Development and Local Application with Focus on Local Buccal, Nasal and Pulmonary Application

Lima-Engelmann

Schneider

2022

CNT

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These days, probiotics are commonly used in functional foods or as dietary supplements. But its positive effect goes far beyond the digestive tract. Local effects of probiotics are currently being studied intensively. The local effect of probiotics in the oral cavity and in the nose has already been examined in some clinical studies. A local pulmonary effect is also of particular interest. In this case, however, studies were only carried out on animals but already elucidated its potential. Various solid and liquid dosage forms are suitable as vehicles for local application. An improved formulation of probiotic products based on pharmaceutical formulation development might bring many different advantages for the effectiveness and duration of action, but also the stability of the probiotic products. Possibilities for the development of suitable probiotic formulations using different methods are presented and explained in more detail. The aim of this review paper is to provide an overview of the current state of clinical research of local application of probiotics and to present the benefits and opportunities of probiotic formulation development.

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Inhaled Treatments and the Future of Respiratory Diseases: Holding Our Breath

Cited by 2 publications

References 8 publications

Lung Microbiota: Its Relationship to Respiratory System Diseases and Approaches for Lung-Targeted Probiotic Bacteria Delivery

Lung Microbiota: Its Relationship to Respiratory System Diseases and Approaches for Lung-Targeted Probiotic Bacteria Delivery

Probiotic Formulation Development and Local Application with Focus on Local Buccal, Nasal and Pulmonary Application

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