Inhaled oxitropium bromide is currently used as the first-line therapy of patients with chronic pulmonary disease in Japan

Efficacy of adding multiple doses of oxitropium bromide to salbutamol delivered by means of a metered-dose inhaler with a spacer device in adults with acute severe asthma

“…In Japan, oxitropium bromide is first-line therapy for patients with chronic pulmonary disease. 29 Third, our study was conducted in a single-blind fashion. Because it was not evaluated whether repeated oxitropium bromide plus salbutamol administration by means of an MDI with a spacer device at this dose is safe and well tolerated, we conducted a single-blind trial.…”