Inhaled nitric oxide prevents systemic and pulmonary vasoconstriction due to hemoglobin-based oxygen carrier infusion: A case report

Polymerized Hemoglobin With Increased Molecular Size Reduces Toxicity in Healthy Guinea Pigs

“…Furthermore, other researchers have noted similar airway irritation and irregular breathing in guinea pigs under isoflurane, so these findings are expected. While not statistically significant, both PolyHb groups ended the experimental protocol with lower pO 2 than control groups, possibly due to pulmonary vasoconstriction, a known consequence of HBOC transfusion that can be alleviated with inhaled NO, or due to the enhanced lung neutrophil activity observed (Figure F,G).…”

Polymerized Hemoglobin With Increased Molecular Size Reduces Toxicity in Healthy Guinea Pigs

“…Furthermore, other researchers have noted similar airway irritation and irregular breathing in guinea pigs under isoflurane, so these findings are expected. While not statistically significant, both PolyHb groups ended the experimental protocol with lower pO 2 than control groups, possibly due to pulmonary vasoconstriction, a known consequence of HBOC transfusion that can be alleviated with inhaled NO, or due to the enhanced lung neutrophil activity observed (Figure F,G).…”

Tracking Research on Hemoglobin-Based Oxygen Carriers: A Scientometric Analysis and In-Depth Review

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Red blood cells-derived components as biomimetic functional materials: Matching versatile delivery strategies based on structure and function

“…Although the oxygen-carrying function of blood is primarily attributed to hemoglobin within RBCs, administration of hemoglobin i.v. directly is associated with several risks: i) Potential risk of the deposition of hemoglobin and RBCs matrix, leading to renal tubular obstruction, renal dysfunction due to heme pigment deposition, and renal toxicity stemming from reduced renal blood flow caused by hemoglobin-induced vasoconstriction; ii) Excessive oxygen transferred by hemoglobin solutions to tissues or infiltrating to the interstitial space between endothelial and smooth muscle cells, reacts with nitric oxide, resulting in the risk of vasoconstriction [ 176 ]; iii) In the absence of the allosteric effector 2,3-diphosphoglyceric acid (2,3-DPG), free hemoglobin demonstrates a high affinity to oxygen, which may result in inadequate oxygen release [ 177 ]; iv. As a natural tetramer, hemoglobin is rapidly degraded into dimers upon administration, which are then quickly filtered by the glomerulus and cleared from circulation, resulting in a shorter half-life for limiting its capacity to transport oxygen over extended periods.…”

Polymerized Hemoglobin With Increased Molecular Size Reduces Toxicity in Healthy Guinea Pigs

“…Furthermore, other researchers have noted similar airway irritation and irregular breathing in guinea pigs under isoflurane, so these findings are expected. While not statistically significant, both PolyHb groups ended the experimental protocol with lower pO 2 than control groups, possibly due to pulmonary vasoconstriction, a known consequence of HBOC transfusion that can be alleviated with inhaled NO, or due to the enhanced lung neutrophil activity observed (Figure F,G).…”

Tracking Research on Hemoglobin-Based Oxygen Carriers: A Scientometric Analysis and In-Depth Review

“……”

“……”

Red blood cells-derived components as biomimetic functional materials: Matching versatile delivery strategies based on structure and function

“…Although the oxygen-carrying function of blood is primarily attributed to hemoglobin within RBCs, administration of hemoglobin i.v. directly is associated with several risks: i) Potential risk of the deposition of hemoglobin and RBCs matrix, leading to renal tubular obstruction, renal dysfunction due to heme pigment deposition, and renal toxicity stemming from reduced renal blood flow caused by hemoglobin-induced vasoconstriction; ii) Excessive oxygen transferred by hemoglobin solutions to tissues or infiltrating to the interstitial space between endothelial and smooth muscle cells, reacts with nitric oxide, resulting in the risk of vasoconstriction [ 176 ]; iii) In the absence of the allosteric effector 2,3-diphosphoglyceric acid (2,3-DPG), free hemoglobin demonstrates a high affinity to oxygen, which may result in inadequate oxygen release [ 177 ]; iv. As a natural tetramer, hemoglobin is rapidly degraded into dimers upon administration, which are then quickly filtered by the glomerulus and cleared from circulation, resulting in a shorter half-life for limiting its capacity to transport oxygen over extended periods.…”

Polymerized Hemoglobin With Increased Molecular Size Reduces Toxicity in Healthy Guinea Pigs

“…Furthermore, other researchers have noted similar airway irritation and irregular breathing in guinea pigs under isoflurane, so these findings are expected. While not statistically significant, both PolyHb groups ended the experimental protocol with lower pO 2 than control groups, possibly due to pulmonary vasoconstriction, a known consequence of HBOC transfusion that can be alleviated with inhaled NO, or due to the enhanced lung neutrophil activity observed (Figure F,G).…”

Tracking Research on Hemoglobin-Based Oxygen Carriers: A Scientometric Analysis and In-Depth Review

“……”

“……”

Red blood cells-derived components as biomimetic functional materials: Matching versatile delivery strategies based on structure and function

“…Although the oxygen-carrying function of blood is primarily attributed to hemoglobin within RBCs, administration of hemoglobin i.v. directly is associated with several risks: i) Potential risk of the deposition of hemoglobin and RBCs matrix, leading to renal tubular obstruction, renal dysfunction due to heme pigment deposition, and renal toxicity stemming from reduced renal blood flow caused by hemoglobin-induced vasoconstriction; ii) Excessive oxygen transferred by hemoglobin solutions to tissues or infiltrating to the interstitial space between endothelial and smooth muscle cells, reacts with nitric oxide, resulting in the risk of vasoconstriction [ 176 ]; iii) In the absence of the allosteric effector 2,3-diphosphoglyceric acid (2,3-DPG), free hemoglobin demonstrates a high affinity to oxygen, which may result in inadequate oxygen release [ 177 ]; iv. As a natural tetramer, hemoglobin is rapidly degraded into dimers upon administration, which are then quickly filtered by the glomerulus and cleared from circulation, resulting in a shorter half-life for limiting its capacity to transport oxygen over extended periods.…”