Inhaled nitric oxide

Vitamin B12Derivatives as Activators of Soluble Guanylyl Cyclase

“…9 Direct inhalation of NO gas is also used to manage persistent pulmonary hypertension in newborns. 10 Although the NO-based activation of sGC currently represents an art-accepted approach to producing useful clinical outcomes, a number of problems are associated with this generalized strategy. For instance, the effectiveness of inhaled NO is patient specific – some patients do not respond to the treatment, while a few even develop adverse reactions.…”

“…These agents are routinely used to manage angina pectoris, myocardial infarction, congestive heart failure, and hypertension . Direct inhalation of NO gas is also used to manage persistent pulmonary hypertension in newborns . Although the NO-based activation of sGC currently represents an accepted approach to producing useful clinical outcomes, a number of problems are associated with this generalized strategy.…”

Cardiopulmonary effects of dexmedetomidine in sevoflurane-anesthetized sheep with and without nitric oxide inhalation

“…17,18 Inhaled NO is efficacious in the treatment of newborn and adult humans with diseases related to pulmonary hypertension. [19][20][21] In lambs and newborn foals, inhaled NO prevents hypoxic pulmonary vasoconstriction [22][23][24] and, to a lesser degree, thromboxanerelated pulmonary hypertension. [23][24][25] The goals of the study reported here were to assess the degree of pulmonary hypertension and impairment of oxygenation induced by administration of dexmedetomidine in anesthetized adult sheep and determine whether these effects were prevented by inhalation of NO.…”

Current Management of Primary Pulmonary Hypertension

“…[129] 8.3 Nitric Oxide and Cyclic Guanosine Monophosphate NO inhalation has also been used in the treatment of pulmonary hypertension. [130][131][132][133][134][135] Since NO is rapidly inactivated by haemoglobin, the vasodilating effect is restricted to the pulmonary vasculature, resulting in reduced PAP without systemic vasodilatation. NO, used in low doses with continuous monitoring, is a safe new therapeutic option in the treatment of PPH.…”