Inhaled Nitric Oxide Inhibits Platelet Aggregation after Pulmonary Embolism in Pigs

Abstract

Inhaled NO has a systemic and rapidly reversible inhibitory effect on platelet aggregation after acute massive PE in pigs. This may be beneficial in treating acute massive PE.

Impact of Inhaled Nitric Oxide on Platelet Aggregation and Fibrinolysis in Rats with Endotoxic Lung Injury

“…Bleeding time is determined by vascular (involving endothelial and smooth muscle cells), platelet, and fibrinolysis parameters. Because no previously published studies, to our knowledge, have performed a complete analysis of those main parameters involved in the hemostatic, coagulation, and fi- brinolytic systems (6,7,(14)(15)(16)(17), we attempted to present a comprehensive analysis of the effects of iNO on these parameters. Moreover, these determinants of BT have been explored according to the inflammatory status of the lungs.…”

Inhaled Nitric Oxide Inhibits Human Platelet Aggregation, P-Selectin Expression, and Fibrinogen Binding In Vitro and In Vivo

“…8 -10 In addition, inhibition of platelet aggregation was also observed during NO inhalation after acute massive pulmonary embolism in pigs. 11 Although several NO-releasing compounds have been investigated and the platelet inhibitory effect has been shown to be dose dependent in vitro and in vivo, [12][13][14][15][16] it is currently unknown whether the inhibitory effect of inhaled NO on platelet function is also dose related. Furthermore, the mechanisms by which inhaled NO may affect platelet function are not completely understood.…”

S-Nitrosothiols: Formation, Decomposition, Reactivity and Possible Physiological Effects

“…Nitric oxide is known to inhibit aggregation of platelets and their adhesion to vascular walls 7 and is also involved in host defense by killing foreign invaders in the immune response. 8 It acts as a messenger molecule; effecting muscle relaxation not only in the vasculature, but also in the gastrointestinal tract.…”

“…Equation (1) can be further simplified by assuming that the forward and reverse rate constants for Reaction R4.6 are rapid enough such that the term k 7 [CySH] in the denominator can be discarded, giving: Figure 4.4b. The congruence of these values for k 6 ; while derived from two separate approaches, proves the general veracity of the simple proposed mechanism.…”

“…This can offer a potential solution to the blood-clotting problems often encountered in blood-containing medical devices, 236 since NO is an excellent inhibitor of blood platelets aggregation. 7 Too many platelets can cause blood clotting, 237 which may obstruct the flow of blood to tissues and organs (ischemia), resulting in stroke and/or heart attack. Bioactive polymer such as poly vinyl chloride …”