Inhaled Nitric Oxide and Pulmonary Edema Formation

Booke, Michael; H, Van Aken; Waurick, René; Hinder, Frank; Meyer, J.; Dl, Traber

doi:10.1097/00003246-199712000-00029

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Therapeutic Implications Based On the Experimental Data1

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2010

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“…In addition, hypoxic pulmonary vasoconstriction, a physiological reflex of the lung to distribute the blood flow to well ventilated areas in order to optimize pulmonary gas exchange, was partly preserved (47,48). However, L-NAME treatment was also associated with several side effects: endotoxin related pulmonary hypertension as well as pulmonary edema were increased by L-NAME administration (17,(49)(50)(51). The total blockage of the endogenous vasodilator NO might be one reason for these side effects.…”

Section: Therapeutic Implications Based On the Experimental Datamentioning

confidence: 99%

The role of nitric oxide and reactive nitrogen species in experimental ARDS

Rehberg

Maybauer

et al. 2010

Front Biosci

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The acute respiratory distress syndrome (ARDS) is associated with a mortality ranging between 40 - 80%. An effective drug therapy, however, is still missing. Many experimental models of ARDS exist enabling a better understanding of the underlying pathophysiology and allowing the establishment of novel therapeutic strategies for the treatment of patients suffering ARDS. Nitric oxide (NO) and reactive nitrogen species (RNS) are increasingly regarded as key substances within the development of ARDS. However, the definite pathomechanism is not completely understood. The purpose of this article is to review the latest results of experimental studies in reference to the role of NO and RNS in the pathogenesis of ARDS. In addition, current large animal models of ARDS are described and future therapeutic approaches are discussed.

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