Inhaled mannitol as a new mucolytic for treatment of cystic fibrosis

Горинова, Ю. В.; Красовский, С. А.; Simonova, O.; Amelina, E.

doi:10.18093/0869-0189-2016-26-6-760-765

Pulʹmonologiâ (Mosk.)

2017

DOI: 10.18093/0869-0189-2016-26-6-760-765

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Inhaled mannitol as a new mucolytic for treatment of cystic fibrosis

Ю. В. Горинова¹,

С. А. Красовский²,

O. Simonova³

et al.

Abstract: Федеральное государственное автономное учреждение «Научный центр здоровья детей» Министерства здравоохранения Российской Федерации: 119991, Москва, Ломоносовский проспект, 2, стр. 1; 2-Федеральное государственное бюджетное учреждение «Научно исследовательский институт пульмонологии Федерального медико биологического агентства России»: 105077, Москва, ул. 11 я Парковая, 32, корп. 4; 3-Государственное бюджетное учреждение здравоохранения города Москвы «Городская клиническая больница имени Д.Д.Плетнева Департамен… Show more

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Cited by 2 publications

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Mannitol therapy for children with cystic fibrosis: efficacy and safety

Simonova

Gorinova

Vysokolova³

et al. 2022

Medicinskij sovet

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The article describes the mechanisms of mucostasis and lung damage in cystic fibrosis. Types of mucolytic therapy and importance of inhalation therapy are considered. The authors presented their own classification of mucoactive agents. The principle of action, advantages and efficacy of mucoactive drugs based on the mannitol molecule are discussed based on the results of multicenter randomized clinical trials, including those conducted in children with cystic fibrosis. The authors present their own experience in the use of mannitol at the Morozovsky Municipal Children Clinical Hospital and 42 BIDA tests for its tolerability, of which 38 tests were passed satisfactorily. We present various clinical cases demonstrating the failure of a tolerance test due to increased signs of respiratory failure (dyspnea), an example of a repeat test 8 months later with satisfactory results, the development of hemoptysis in a patient seen in the pulmonology department of the National Medical Research Center for Children’s Health. The case was described in an adolescent, and after mannitol inhalation was added to the existing basic therapy, there was a clear positive trend in flowmetry: FEV1-74% (a significant increase of 14%). Thus, the authors noted that mannitol is effective in children with cystic fibrosis over 6 years of age; its use is characterized by good compliance and general adherence to therapy due to convenience of use: no need for additional technical means to perform inhalation in the form of solutions outside the home and saving overall free time. An important observation noted by the authors is that the BIDA test should be performed in complete clinical and laboratory remission to obtain objective results.

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Mannitol therapy for children with cystic fibrosis: efficacy and safety

Simonova

Gorinova

Vysokolova³

et al. 2022

Medicinskij sovet

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Commercial algae in the White and Black Seas of the Russia coastal zones: stocks, chemical composition, structure, properties of polysaccharides, rational use

Podkorytova,

Usov,

Evseeva

et al. 2023

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Aim: To analyze published data on the distribution, stocks of brown and red algae in the White and Black Seas, as well as on the chemical structure and properties of polysaccharides and their use. Evaluate the effectiveness of chemical-technological research and its results.Methods used: In preparing the review, science-metric methods of literature analysis from the databases of the RSCI, Scopus were used, as well as our own published research results, which used the methods of IR spectroscopy, carbon‑13 nuclear magnetic resonance (13С-NMR) and standard methodsResult: A review of the scientific literature on the distribution, stocks and use of algae in the White and Black Seas of the coastal zones of Russia are presented. Data on the study of the chemical composition, technological properties and chemical structure of polysaccharides from the White Sea brown algae — Fucus vesiculosus and Ascophyllum nodosum, as well as Gongolaria barbata, Ericaria crinita — Black Sea and red algae A. plicata of the White Sea and 2 species — Coccotylus brodiei and Phyllophora crispa of the Black Sea.Novelty: Alginates from Cystoseira have been shown to contain about 35% L-guluronic acid. The chemical structure of the polysaccharide from Phyllophora crispa has been confirmed as kappa-omega-carrageenan. The prospect of using A. plicata residues after agar extraction and their processing as secondary raw materials to obtain microcrystalline cellulose, nanocellulose or amino acid hydrolyzate was shown.Practical significance: The presented data on the distribution of algae stocks and the recommended yield (RY), their chemical composition, as well as the structure and properties of polysaccharides can be used to draw up recommendations for regulating fisheries and planning production.

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Inhaled mannitol as a new mucolytic for treatment of cystic fibrosis

Cited by 2 publications

References 28 publications

Mannitol therapy for children with cystic fibrosis: efficacy and safety

Mannitol therapy for children with cystic fibrosis: efficacy and safety

Commercial algae in the White and Black Seas of the Russia coastal zones: stocks, chemical composition, structure, properties of polysaccharides, rational use

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