Inhaled IgG1 antibodies: The buffering system is an important driver of stability during mesh-nebulization

Mayor, Alexie; Thibert, Béatrice; Huille, Sylvain; Bensaid, Fethi; Respaud, Renaud; Audat, Héloïse; Heuzé-Vourc’h, Nathalie

doi:10.1016/j.ejpb.2022.11.006

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Protein Aggregation In Parenteral Versus Inhaled Products1

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Cited by 4 publications

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“…It is possible to employ light obscuration method of USP <788> for detection of particles, including protein aggregates in inhaled products, as a simple and robust approach for formulation and/or process screening purposes. For instance, the detection of higher levels of soluble and/or insoluble protein aggregates post nebulization or spray drying indicates that the formulation and/or the drying process led to protein unfolding and denaturation 8 , 15 , 31 , 32 . The analytical testing for protein aggregates should be designed to prevent creation or reduction of protein aggregation during sample collection 33 or handling 27 .…”

Section: Protein Aggregation In Parenteral Versus Inhaled Productsmentioning

confidence: 99%