Inhaled Corticosteroids

Allen, David B.; Bielory, Leonard; Derendorf, Hartmut; Dluhy, Robert; Colice, Gene; Szefler, Stanley J.

doi:10.1016/s0091-6749(03)01859-1

Cited by 198 publications

(20 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In regard to the high risk of adverse effects of glucocorticoids including diabetogenesis, osteoporosis, muscle wasting, skin thinning and weight gain [1, 30], and the above noted corticosteroid insensitivity, more effective anti-inflammatory therapeutic approaches are needed to explore. So, we used a mouse model of chronic exposure to ozone that leads to airway inflammation and lung destruction, to investigate whether IL-17mAb can overcome the glucocorticoids insensitivity.…”

Section: Introductionmentioning

confidence: 99%

IL-17A Monoclonal Antibody Partly Reverses the Glucocorticoids Insensitivity in Mice Exposed to Ozonec

Xia

Zhang

et al. 2017

Inflammation

View full text Add to dashboard Cite

Exposure to ozone has been associated with airway inflammation and glucocorticoid insensitivity. This study aimed to observe the capacity of anti-murine interleukin-17A monoclonal antibody (IL-17mAb) to reverse ozone-induced glucocorticoid insensitivity and to detect its effects with glucocorticoids in protecting against airway inflammation. After C57/BL6 mice were exposed to ozone (2.5 ppm; 3 h) for 12 times over 6 weeks, PBS, IL-17mAb (50 ug/ml), dexamethasone (2 mg/kg), and combination administration of IL-17mAb (50 ug/ml) and dexamethasone (2 mg/kg) were intraperitoneally injected into mice at a dose of 0.1 ml, respectively, for 10 times over 5 weeks. At sacrifice, lung histology, airway inflammatory cells, levels of related cytokines in bronchoalveolar lavage fluid (BALF), and serum were analyzed, airway inflammatory cell infiltration density and mean linear intercept (Lm) were measured, the expression of IL-17A mRNA, glucocorticoid receptors (GR), NF-κB, and p38 mitogen-activated protein kinase (MAPK) phosphorylation were determined. We found that combination administration markedly reduced ozone-induced total inflammatory cells, especially neutrophils; inhibited levels of cytokines, including IL-8, IL-17A, and TNF-α in BALF; and suppressed airway inflammatory cell infiltration density and Lm. Additionally, combination administration significantly elevated levels of IFN-γ in BALF, decreased the dexamethasone-induced increase of IL-17A mRNA, and increased the expression of GR and decrement of NF-κB and p38MAPK phosphorylation, which are also related to glucocorticoids insensitivity. Collectively, combination administration shows profound efficacy in inhibiting certain cytokines, and IL-17 mAb partly improved the glucocorticoids insensitivity via modulating the enhanced production rate and improving expression of IL-17A induced by glucocorticoids administration and p38MAPK, NF-κB signaling pathway.

show abstract

Section: Introductionmentioning

confidence: 99%

IL-17A Monoclonal Antibody Partly Reverses the Glucocorticoids Insensitivity in Mice Exposed to Ozonec

Xia

Zhang

et al. 2017

Inflammation

View full text Add to dashboard Cite

show abstract

“…The number of studies concerning the effects of inhaled fluticasone propionate (FP) on the mineral status of bone is limited and results are conflicting [8,9]. Although large studies have reported no substantial risk of ICS on bone metabolism in children with asthma [10,11,12], there are no new data available as to long-term intermittent FP use and its effects on children’s bone metabolism and its associated biomarkers.…”

Section: Introductionmentioning

confidence: 99%

Osteocalcin, Cortisol Levels, and Bone Mineral Density in Prepubertal Children with Asthma Treated with Long-Term Fluticasone Propionate

et al. 2012

View full text Add to dashboard Cite

Aims: The objective of this study is to determine the effects of the long-term treatment with inhaled fluticasone propionate on osteocalcin, cortisol levels, and bone mineral status in children with asthma. Methods: This cross-sectional study examined 230 prepubertal children with asthma (aged 6–11) who had intermittently used inhaled fluticasone propionate for at least 5 years at a mean daily dose of 200 µg (range: 200–350 µg). Serum osteocalcin, cortisol, and bone mineral density (BMD) of the lumbar spine were obtained from each participant. The control group consisted of gender- and age-matched children (n = 170) who were newly diagnosed with asthma and who were not being treated with corticosteroid. Results: The average age (±SEM) was 8.9 ± 0.7 years, their mean (±SEM) daily steroid dose was 180.3 ± 55.0 µg, with 236.5 ± 17.2 g total steroid use during treatment. Between the study and the control groups, no significant differences were observed in cortisol, osteocalcin levels, and BMD (p > 0.05). Conclusion: Long-term treatment with inhaled fluticasone propionate (100 µg twice daily) revealed no negative effects on serum osteocalcin, cortisol levels, and BMD in children with asthma.

show abstract

“…Only the unbound fraction of a drug in plasma is available for many pharmacokinetic and pharmacodynamic processes, such as membrane permeation and receptor binding [1][2][3]. In the case of inhaled corticosteroids, it is widely believed that high protein binding is desirable in order to minimise systemic side effects and hence maximise the therapeutic index [4][5][6]. For this reason it was necessary to have an appropriate screen for plasma protein binding in place during the lead optimisation stage of a glucocorticoid receptor agonist research programme.…”

Section: Introductionmentioning

confidence: 99%

Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids

Taylor

Harker

2006

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

Inhaled Corticosteroids

Cited by 198 publications

References 108 publications

IL-17A Monoclonal Antibody Partly Reverses the Glucocorticoids Insensitivity in Mice Exposed to Ozonec

IL-17A Monoclonal Antibody Partly Reverses the Glucocorticoids Insensitivity in Mice Exposed to Ozonec

Osteocalcin, Cortisol Levels, and Bone Mineral Density in Prepubertal Children with Asthma Treated with Long-Term Fluticasone Propionate

Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids

Contact Info

Product

Resources

About