Inhaled corticosteroids in asthma

Douglass, Jo A; Bowes, Glenn

doi:10.5694/j.1326-5377.1990.tb125307.x

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…The clinical significance of the effects of the inhaled steroids on the HPA axis has been considered by several reviewers (Douglass & Bowes 1990;Geddes 1992;Greenberger 1992;Kamada et al 1992;Kerrebijn 1990;Konig 1988;Larsen 1992;Szefler 1991;Stead & Cooke 1989;Van Asperen et at. 1992).…”

Section: Hypothalamic-pituitary-adrenal (Hpa) Axis Suppressionmentioning

confidence: 99%

Inhaled Corticosteroids in Children

Boner

Piacentini

1993

Drug Safety

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Inhaled corticosteroids are effective for the treatment of asthma. Because of the appreciation of the importance of airway inflammation in the pathogenesis of the disease, these drugs are being used more frequently not only in severe but also in moderate asthma. Treatment rarely has to be stopped because of topical adverse effects since oropharyngeal candidiasis and dysphonia are uncommon in children. However, paediatricians need to remain alert for the possibility of systemic adverse effects. With sensitive techniques, dose-dependent adrenal suppression has been documented in children treated with inhaled steroids but generally this effect has no clinical relevance. Although suppression of short term growth velocity has been reported, long term studies have shown that when growth impairment occurs in a child with asthma it is more likely to reflect poor asthma control than the administration of inhaled corticosteroids. Calcium supplementation may be necessary in children with asthma treated with inhaled steroids since this treatment may cause reduction in osteocalcin, a marker of osteoblast activity and bone formation. Other systemic adverse effects have been reported in case reports. The use of a large spacer device has been shown to reduce the incidence of both topical and systemic adverse effects from inhaled steroids and their use should be encouraged. In any child with asthma who really needs inhaled steroids, the lowest dose possible should be prescribed; however, the mistake of prescribing doses too low to be therapeutically effective should be avoided.

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Section: Hypothalamic-pituitary-adrenal (Hpa) Axis Suppressionmentioning

confidence: 99%

Inhaled Corticosteroids in Children

Boner

Piacentini

1993

Drug Safety

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Airway Structure in Asthma: A Role for Confocal Microscopy?

Goldie

Fernandes

Rigby

et al. 1998

Pulmonary Pharmacology & Therapeutics

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Update on cUrrent therapy of asthma

Sadigh

MoSkowitZ²,

SHAYMURATOV³

et al. 2012

BCCM

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I ntroduction. Approximately 7% of Americans and 2-5% of Russians currently have asthma [1,2,3]. Asthma is characterized by airflow obstruction, bronchial hyperresponsiveness, and inflammation. This inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, which is usually worse at night and in the early morning. There are several inflammatory mediators that have been implicated in the inflammatory process, and management of these mediators can be used to treat the symptoms of asthma. The initiation of asthma therapy is based on the severity of the individual's asthma [4]. Symptoms are controlled with beta 2-agonists and inhaled corticosteroids in the majority of asthmatics. However many patients with severe asthma and poorly controlled symptoms require additional forms of therapy. This review focuses on current asthma therapy as well as

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Inhaled corticosteroids in asthma

Cited by 3 publications

References 55 publications

Inhaled Corticosteroids in Children

Inhaled Corticosteroids in Children

Airway Structure in Asthma: A Role for Confocal Microscopy?

Update on cUrrent therapy of asthma

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