Inhaled corticosteroids and bone mineral density at school age: A follow‐up study after early childhood wheezing

Sidoroff, Virpi; Ylinen, Mari K; Kröger, Liisa; Kröger, Heikki; Korppi, Matti

doi:10.1002/ppul.22968

Cited by 22 publications

(18 citation statements)

References 29 publications

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“…Rodriguez‐Martinez et al found that treating patients with recurrent wheezing or mild persistent asthma with daily inhaled corticosteroids results in higher gain in quality adjusted life years (QALY) compared to intermittent treatment . Sidoroff et al reported that regular inhaled corticosteroid use for longer than 6 months in children aged less than 6 years was associated with decreased bone mineral density in the lumbar spine; the amount of the cumulative dose until age 12 was correlated with the amount of decrease in femoral bone mineral density . Petsky et al studied asthmatic children randomized to use of fractional exhaled nitric oxide (FeNO) monitoring as a treatment guide, and found that use of FeNO was associated with decreased severe exacerbations.…”

Section: Asthmasupporting

confidence: 68%

“…18 Sidoroff et al reported that regular inhaled corticosteroid use for longer than 6 months in children aged less than 6 years was associated with decreased bone mineral density in the lumbar spine; the amount of the cumulative dose until age 12 was correlated with the amount of decrease in femoral bone mineral density. 19 Petsky et al studied asthmatic children randomized to use of fractional exhaled nitric oxide (FeNO) monitoring as a treatment guide, and found that use of FeNO was associated with decreased severe exacerbations. However, the total dose of inhaled corticosteroids was higher in this group, and there was no effect on quality of life, lung function tests or control.…”

Section: Asthma Managementmentioning

confidence: 99%

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Pediatric pulmonology year in review 2015: Part 3

et al. 2016

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Our journal covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review covers articles on neonatal lung disease, pulmonary physiology, and respiratory infection.Word count: 71 3

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Section: Asthmasupporting

confidence: 68%

Section: Asthma Managementmentioning

confidence: 99%

Pediatric pulmonology year in review 2015: Part 3

et al. 2016

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“…Initiation of inhaled glucocorticoids at a young age has potential effects on bone accrual, peak bone mass and growth in addition to the cumulative lifetime effects of these medications. Of concern are recent studies in pediatric populations, which have demonstrated detrimental effects of these medications on bone growth and density [35, 37, 38]. …”

Section: Skeletal Effects Of Inhaled Glucocorticoids In Pediatric Astmentioning

confidence: 99%

“…In another study, children who received regular inhaled glucocorticoid treatment before 6 years of age, had significantly reduced BMD at the lumbar spine (mean aBMD=0.81, 95% CI 0.74–0.90) detected by late school age (median age 12.3 years) compared to those who had never used these medications. This analysis did not find a significant impact on BMD in the children with regular IGC use between 6 and 12 years of age, suggesting that exposure before 6 years of age may have the most critical impact [38]. …”

Section: Skeletal Effects Of Inhaled Glucocorticoids In Pediatric Astmentioning

confidence: 99%

The Skeletal Effects of Inhaled Glucocorticoids

Sutter

Stein

2016

Curr Osteoporos Rep

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The skeletal effects of inhaled glucocorticoids are poorly understood. Children with asthma treated with inhaled glucocorticoids have lower growth velocity, bone density, and adult height. Studies of adults with asthma have reported variable effects on BMD, although prospective studies have demonstrated bone loss after initiation of inhaled glucocorticoids in premenopausal women. There is a dose response relationship between inhaled glucocorticoids and fracture risk in asthmatics; the risk of vertebral and non-vertebral fractures is greater in subjects treated with the highest doses in the majority of studies. Patients with COPD have lower BMD and higher fracture rates compared to controls, however, the majority of studies have not found an additional detrimental effect of inhaled glucocorticoids on bone. While the evidence is not conclusive, it supports using the lowest possible dose of inhaled glucocorticoids to treat patients with asthma and COPD and highlights the need for further research on this topic.

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“…The bone adapts to mechanical stress, largely changing the size and shape that are the main factors of resistance to fracture (Turner, 2006). Specific characteristics of the skeleton in different species of mammals are interdependent due to environmental, adaptive , physiological (Stynder, 2008;Coates et al, 2016), specific (McClure et al, 2001) indicators not only in animals but also in humans (Sidoroff et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

X-ray densitometric indices of proximal phalanx, medial phalanx and ungular pelvic limb bones as criteria for age diagnosis of cattle in forensic veterinary expertise

Yatsenko

Tkachuk

Busol

et al. 2019

Regul. Mech. Biosyst.

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Morphological parameters of biological material are extremely informative in diagnostic studies, in particular, to determine the species, sex, time of death, the term of burial. The most informative object for these tasks is the skeleton, because changes in the bones are stored for a long time, while soft tissue is subjected to rotting. Bone tissue is the most durable, but at the same time, it is very labile and reacts to all metabolic processes in the body. The object of the study was proximal phalanx, medial phalanx and ungular bone of the pelvic limb of cattle ranging in age from newborn to 12 years old. Radiography of the proximal phalanx, medial phalanx and ungular bones of the pelvic limb was performed on the Arman apparatus. The bones were subjected to X-ray in the lateromedial projection. The inner and outer sections of the tubular bone were determined. The mathematical modeling of the interaction of X-rays and the cortical layer of bones of fingers (proximal phalanx, medial phalanx and ungular) of cattle was carried out in this work. It is established that this process is described by Bouger's law. The physico-mathematical model of proximal phalanx, medial phalanx and ungular bones has been calculated, on the basis of which it was possible to calculate the X-ray densitometric indices of these bones of cattle. The age features of dynamics of X-ray densitometric indices of the proximal phalanx, medial phalanx and ungular bones were established and a method of determining the age of cattle according to this criterion was proposed. A mathematical model for the proximal phalanx, medial phalanx and ungular bones of the pelvic limbs of cattle that can be applied in X-ray densitometry uses: for the average third proximal phalanx – section of heterogeneous tubular structure modeled by a semicircle; for a medial phalanx bone – a section of a triangular shape; for the ungular bone – a heterogeneous structure, the plantar surface is inscribed in a rectangle. The process of interaction of X-rays with the bone structure of the examined pelvic limb bones can be described by Bouguer's law. The developed mathematical modeling of this interaction and the algorithm for its analysis is the basis for determining the age of cattle for X-ray densitometric indices of the proximal phalanx, medial phalanx and ungular bones of pelvic limbs. By X-ray densitometry of the proximal phalanx and medial phalanx bones of the pelvic limbs extremities one can diagnose the age of bovine animals from birth to 5 years, but according to ungular bones – from birth to 10 years. X-ray densitometry of medial phalanx and ungular bones of pelvic limbs can be used for diagnosing bovine cattle in a complex with other morphological, chemical and physical methods of investigation.

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Inhaled corticosteroids and bone mineral density at school age: A follow‐up study after early childhood wheezing

Abstract: ICS use during childhood may be related to a decrease in BMD at late school age. It is important to use the lowest possible ICS dose that maintains adequate asthma control.

Cited by 22 publications

References 29 publications

Pediatric pulmonology year in review 2015: Part 3

Pediatric pulmonology year in review 2015: Part 3

The Skeletal Effects of Inhaled Glucocorticoids

X-ray densitometric indices of proximal phalanx, medial phalanx and ungular pelvic limb bones as criteria for age diagnosis of cattle in forensic veterinary expertise

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