Inhaled corticosteroid therapy: A substitute for theophylline as well as prednisolone?

Clark, T. J. H.

doi:10.1016/0091-6749(85)90649-9

Cited by 33 publications

(6 citation statements)

References 17 publications

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“…Further analyses of the mechanisms in volved in GC action on cytokine transcription and release from mast cells are thus desirable since they may help to clarify important ther apeutic problems like steroid resistance in asthmatics where GC are First-line drugs [21]. They may also provide clues that would help in tailoring GC-like drugs towards inhibition against specific cytokines that may play a key role in specific diseases.…”

Section: Discussionmentioning

confidence: 99%

Modulation of in vitro Cytokine Release from Human Leukemic Mast Cells (HMC-1) by Glucocorticoids

Lippert¹,

Welker²,

Krüger‐Krasagakes³

et al. 1996

Skin Pharmacol Physiol

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Mast cells are well known effector cells not only in allergic but also in diverse acute and chronic inflammatory diseases. We have shown previously that these cells produce a broad spectrum of cytokines which might contribute to mast cell-dependent pathology. In the present study, we have investigated the influence of four potent glucocorticoids, methylprednisolone-aceponate, methylprednisolone-17-propionate, prednicarbate, and betametasone valerate (10⁵M-10^-9M), on the IL-1Β, IL-3, IL-8, and tumor necrosis factor Α secretion of the HMC-1 mast cell line as measured by ELISA. All four glucocorticoids caused a comparable dose- and time-dependent inhibition of cytokine release from HMC-1 cells stimulated for 24 h with phorbol 12-myristate 13-acetate 25 ng/ml and calcium ionophore 2 × 10^-7M. These results shed further light on the mechanisms involved in antiinflammatory effects of glucocorticoids in allergic inflammation.

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Section: Discussionmentioning

confidence: 99%

Modulation of in vitro Cytokine Release from Human Leukemic Mast Cells (HMC-1) by Glucocorticoids

Lippert¹,

Welker²,

Krüger‐Krasagakes³

et al. 1996

Skin Pharmacol Physiol

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“…However, they do not influence the basic pathophysiological mechanism of this disease. Many reports confirm that corticosteroid aerosol therapy is effective in reducing levels of bronchial hyper-responsiveness in asthma (Clark 1985;Ryan et al 1985;Dutoit et al 1987). The adverse effects of steroids can largely be avoided by giving beclomethasone by aerosol, and there is increasing evidence that inhaled beclomethasone is effective in the management of patients with asthma (Brogden et al 1984;Konig 1988).…”

Section: Discussionmentioning

confidence: 99%

TIME COURSE OF RECOVERY OF β‐ AND α₁‐ADRENOCEPTORS IN EXPERIMENTAL ASTHMA

Shindoh

Sugiyama

Hayashi

et al. 1990

Clin Exp Pharma Physio

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1. The time course of recovery of reduced beta-adrenoceptors caused by ovalbumin (OA) challenge was investigated using guinea-pigs. 2. The effects of prednisolone on the recovery time course were also evaluated. 3. beta- and alpha 1-receptor assays were performed using lung membranes. Adenylate cyclase activity was also measured. 4. OA challenge reduced the number of beta-adrenoceptors by 35%, and a significant decrease (13%) persisted for 7 days. The number of beta-adrenoceptor recovered after 14 days. 5. OA challenge elevated the number of alpha 1-adrenoceptors. A significant increase (24%) was observed after 7 days, and it took a further 7 days for the recovery. 6. After OA challenge there was a significant decrease in adenylate cyclase activity after 7 days, which recovered after a further 7 days. 7. Inhalation of prednisolone accelerated the recovery of beta-adrenergic responsiveness, though it did not affect the recovery of the number of alpha 1-adrenoceptors. Prednisolone inhalation also elevated beta-adrenergic responsiveness in non-asthmatic subjects. 8. It is concluded that reduced beta-adrenergic responsiveness caused by OA challenge persisted for 7 days and recovered after a further 7 days. Steroid hormone increased beta-adrenoceptors.

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“…Overreli ance on bronchodilators could even mask the progress of the disease. Inhaled ste roids are widely used to provide effective treatment for the inflammatory compo nents of asthma with less risk of systemic side effects occurring than with oral ste roids [25]. Side effects can still occur, how ever [26,27], and may become more com mon with the availability of higher-dose inhaled steroid preparations.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the subjects were classed as moderately severe asthmatics and were largely maintained on inhaled bronchodilalors (72 patients), oral bronchodilators (51) and inhaled steroids (25).…”

Section: Patient Characteristicsmentioning

confidence: 99%

Effectiveness of Nedocromil Sodium versus Placebo as Additions to Routine Asthma Maintenance Therapy: a Multicentre, Double-Blind, Group Comparative Trial

Bianco¹,

Bono

Grassi

et al. 1989

Respiration

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A total of 117 subjects took part in a double-blind, placebo-controlled trial of nedocromil sodium (4 × 4 mg daily by inhalation) in the management of patients with moderately severe bronchial asthma. Treatment was randomly allocated and was continued for 12 weeks following a 2-week baseline period on routine asthma therapy.Statistically significant differences for nedocromil sodium versus placebo were found for diary card asthma severity scores, morning and evening peak flow measurements and daily bronchodilator usage. The clinicians’ assessments of asthma severity and global opinions of treatment efficacy were also significantly in favour of nedocromil sodium. Overall, the clinical status of these asthmatic patients was improved by adding nedocromil sodium onto their existing therapy.

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Inhaled corticosteroid therapy: A substitute for theophylline as well as prednisolone?

Cited by 33 publications

References 17 publications

Modulation of in vitro Cytokine Release from Human Leukemic Mast Cells (HMC-1) by Glucocorticoids

Modulation of in vitro Cytokine Release from Human Leukemic Mast Cells (HMC-1) by Glucocorticoids

TIME COURSE OF RECOVERY OF β‐ AND α₁‐ADRENOCEPTORS IN EXPERIMENTAL ASTHMA

Effectiveness of Nedocromil Sodium versus Placebo as Additions to Routine Asthma Maintenance Therapy: a Multicentre, Double-Blind, Group Comparative Trial

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Inhaled corticosteroid therapy: A substitute for theophylline as well as prednisolone?

Cited by 33 publications

References 17 publications

Modulation of in vitro Cytokine Release from Human Leukemic Mast Cells (HMC-1) by Glucocorticoids

Modulation of in vitro Cytokine Release from Human Leukemic Mast Cells (HMC-1) by Glucocorticoids

TIME COURSE OF RECOVERY OF β‐ AND α1‐ADRENOCEPTORS IN EXPERIMENTAL ASTHMA

Effectiveness of Nedocromil Sodium versus Placebo as Additions to Routine Asthma Maintenance Therapy: a Multicentre, Double-Blind, Group Comparative Trial

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TIME COURSE OF RECOVERY OF β‐ AND α₁‐ADRENOCEPTORS IN EXPERIMENTAL ASTHMA