Inhaled corticosteroid for persistent cough following upper respiratory tract infection

Abstract

Inhaled corticosteroid is ineffective in treating persistent post-URTI cough in previously healthy individuals.

Antitussive Drugs—Past, Present, and Future

“…Gillissen et al (2007) reported significantly faster and greater decline in cough frequency with extra-fine HFA-BDP compared with placebo in patients with cough lasting more than 3 days but less than 2 weeks. However, Pornsuriyasak et al (2005) found no effect of inhaled budesonide (400 mg twice a day) given for 4 weeks in patients with cough lasting more than 3 weeks after a URTI.…”

Treatments for subacute cough in primary care: systematic review and meta-analyses of randomised clinical trials

“…Six RCTs were eligible (Table 1). [26][27][28][29][30][31] The studies were typically small, including between 30 and 276 patients (median 96, interquartile range [IQR] 76-170), and were…”

“…conducted between 2000 and 2012 in the UK, 26 Italy, 27 Netherlands, 30 Thailand, 31 Iran, 29 or multicentrically (that is, Europe, South America, and Africa). 28 They explored effects of orally administered montelukast, 26 inhaled salbutamol plus ipratropium bromide, 27 oral gelatine, 29 inhaled fluticasone propionate, 30 and inhaled budesonide 31 (Table 1). One study had three study arms investigating an orally active selective nociception opioid 1 (NOP1) receptor agonist and oral codeine.…”

“…Five studies blinded patients and care providers, or were reported as double blind. [26][27][28]30 Wang 26 and Pornsuriyasak 31 also reported blinded outcome assessment. Zanasi was deemed to have a substantial risk of bias because patients with symptom increase or indications of harm (adverse events) were excluded from analyses.…”

Efficacy of anti-inflammatory or antibiotic treatment in patients with non-complicated acute bronchitis and discoloured sputum: randomised placebo controlled trial

“…47 In another study, budesonide taken for four weeks did not reduce cough scores compared with placebo in patients coughing for three weeks or longer after an upper respiratory tract infection. 48 Two other studies evaluated the effect of inhaled beclomethasone dipropionate on cough score in patients with post-infectious acute cough (less than three weeks' duration). 49 50 In one of the studies treatment with inhaled steroid resulted in a greater reduction of cough frequency than placebo, but in the other study there was no benefit.…”