2015
DOI: 10.1016/j.jpain.2015.07.009
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Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data

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Cited by 200 publications
(176 citation statements)
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References 87 publications
(183 reference statements)
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“…29 Patients showing an insufficient response or a major side effect to these agents may benefit from the opioids tramadol, fentanyl, or buprenorphine and even from inhaled medical cannabis. 36 Poorly validated treatments are lidocaine patches or creams, transcutaneous electrical nerve stimulation, and acupuncture (see Table 3). [27][28][29] In the absence of convincing clinical evidence and with a potential risk for drug interference, we do not recommend the routine use of high-dose vitamins or other neuroprotective strategies.…”
Section: Comments About Patient 1 Peripheral Neuropathymentioning
confidence: 99%
“…29 Patients showing an insufficient response or a major side effect to these agents may benefit from the opioids tramadol, fentanyl, or buprenorphine and even from inhaled medical cannabis. 36 Poorly validated treatments are lidocaine patches or creams, transcutaneous electrical nerve stimulation, and acupuncture (see Table 3). [27][28][29] In the absence of convincing clinical evidence and with a potential risk for drug interference, we do not recommend the routine use of high-dose vitamins or other neuroprotective strategies.…”
Section: Comments About Patient 1 Peripheral Neuropathymentioning
confidence: 99%
“…Double blind randomized clinical trials have shown that inhaled THC, a key constituent of C. sativa, significantly decreased allodynia, and was suggested that this effect is due to THC specific suppression of central and peripheral sensitization. 80,96 The third most potent herb was F. hermonis. Interestingly, there has been no detailed clinical studies investigating F. hermonis in the amelioration of NP reported in the English language.…”
Section: Discussionmentioning
confidence: 99%
“…This study showed a 30% reduction in chronic pain improvement at the individual patient level. 80 Therefore, cannabinoids open doors for a future treatment for NP. Elder has shown significant effects towards amelioration of mechanical allodynia and hyperalgesia 24 Elder were fractioned by RP-column chromatography and RP-HPLC, and showed that the most effective compound was kaempferol.…”
mentioning
confidence: 99%
“…Inhaled or vaporized cannabis has also been studied, but, again, few randomized trials have been conducted. A recently published meta-analysis demonstrated that 1 in 5-6 patients would benefit from the use of inhaled cannabis treatments for neuropathic pain 43 .…”
Section: Painmentioning
confidence: 99%