Inhaled braylin regulates Th2 response and induces relaxant effects in the airway muscles in a model of ovalbumin-induced asthma

Santo, Renan Fernandes do Espírito; Meira, Cássio Santana; Opretzka, Luiza Carolina França; Silva, Karoline Cristina Jatobá da; Araujo, Fênix Alexandra de; Costa, Rafael dos Santos; Velozo, Eudes da Silva; Formiga, Fabio Rocha; Silva, Darízy Flávia; Soares, Milena Botelho Pereira; Villarreal, Cristiane Flora

doi:10.1016/j.phyplu.2023.100435

Cited by 1 publication

(3 citation statements)

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“…The intravenous administration was conducted through the lateral tail vein, and the inhalation dosing was conducted using inhalation exposure chambers. The nebulizer device was operated according to the manufacturer’s specifications [ 15 ]. The blood samples were collected 0.083, 0.25, 0.5, 0.75, 1, 2, and 4 h after both administrations.…”

Section: Methodsmentioning

confidence: 99%

“…The current research is a continuation of previously published work [6,14,15]. Briefly, 6-methoxyseselin was identified and isolated from the roots of Zanthoxylum tingoassuiba A. St. Hil (Rutaceae) by the Medical Research Laboratory (LAPEMM) of the Federal University of Bahia (UFBA) (Brazil), which were collected in Feira de Santana, Brazil, 12°12′52.9″ S, 38°52′44.1″ W. A voucher specimen (no.…”

Section: Chemicals and Reagentsmentioning

confidence: 96%

“…Recently, the antiasthmatic properties have been demonstrated. Inhaled 6-methoxyseselin reduced, in a dose-dependent manner, key pathophysiological events of experimental asthma, with similar efficacy to systemic dexamethasone, considered the standard gold drug [ 15 ]. These data highlight the potential of coumarin as a candidate for the drug discovery process of new anti-asthmatic drugs.…”

Section: Introductionmentioning

confidence: 99%

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Preclinical Pharmacokinetic Study and Lung Penetration of a Coumarin Extracted from Zanthoxylum tingoassuiba

Santos,

da Hora Borges,

Jatobá da Silva

et al. 2024

Pharmaceutics

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The compound 6-methoxyseselin, derived from Zanthoxylum tingoassuiba, demonstrates various therapeutic properties, including vasorelaxation, antinociceptive, anti-inflammatory, and immunomodulatory effects, along with recently discovered antiasthmatic properties. This study aimed to evaluate its preclinical pharmacokinetics and pulmonary delivery in Balb/c mice. The method involved administering the compound via inhalation and intravenous routes, followed by blood sample collection for analysis using high-performance liquid chromatography with diode array detection (HPLC-DAD). The results indicated good linearity, precision, accuracy, and stability of the compound in the biological samples. Pharmacokinetic parameters such as the rate of elimination, half-life, clearance, volume of distribution, area under the curve, and mean residence time were determined for both administration routes, showing similar profiles. The lung concentrations were notably higher than the plasma concentrations, indicating significant lung penetration. These findings suggest 6-methoxyseselin as a promising candidate for new anti-asthmatic drugs, supported by its favorable pharmacokinetic profiles and high lung penetration factors. This study represents the first exploration of the pharmacokinetics and pulmonary delivery of 6-methoxyseselin in mice, highlighting its potential for further drug development.

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Section: Methodsmentioning

confidence: 99%

Section: Chemicals and Reagentsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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