Inhaled antibiotics and airway bacterial decolonization for patients with chronic obstructive pulmonary disease: The rationale and future

Han, Yaopin; Hua, Jenna; He, Binfeng; Zhang, Jing

doi:10.2478/jtim-2022-0005

Cited by 11 publications

(8 citation statements)

References 30 publications

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“…Prevention of AECOPD by modifying the lower respiratory tract using different medications was suggested. 41 In conclusion, the present multicentric study documented the microbial profile of the upper and lower respiratory tract of Egyptian patients with AECOPD. We could identify a distinctive pattern of inflammatory cell distribution in sputum and BAL samples of AECOPD patients.…”

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confidence: 62%

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Bacterial Species and Inflammatory Cell Variability in Respiratory Tracts of Patients with Chronic Obstructive Pulmonary Disease Exacerbation: A Multicentric Study

Salama¹,

Moazen²,

Elsawy³

et al. 2023

IDR

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Background and Aim Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has profound effects on disease progression and patients’ quality of life. Emerging evidence suggests an association between alterations in the respiratory microbiome flora species and airway inflammation in patients with AECOPD. The present study aimed to describe the inflammatory cells and bacterial microbiome distributions in respiratory tract in Egyptian patients with AECOPD. Subjects and Methods The present cross-sectional study included 208 patients with AECOPD. Sputum and broncho-alveolar lavage samples from the studied patients were submitted to microbial cultures using appropriate media. Total and differential leukocytic counts and were done via automated cell counter. Results The present study included 208 AECOPD patients. They comprised 167 males (80.3%) and 41 females (19.7%) with an age of 57.9 ± 4.9 years. AECOPD was categorized as mild, moderate and severe in 30.8%, 43.3% and 26%, respectively. Sputum samples had significantly higher TLC, neutrophil percent and eosinophil percent when compared with BAL samples. In contrast, lymphocyte percent was significantly higher in BAL samples. Sputum specimens had significantly lower frequency of positive growths (70.2% versus 86.5%, p = 0.001). Among the identified organisms, sputum specimens had significantly lower frequency of Strept. pneumoniae (14.4% versus 30.3%, p = 0.001), Klebsiella pneumoniae (19.7% versus 31.7%, p = 0.024), Haemophilus influenzae (12.5% versus 26.9%, p = 0.011), Pseudomonas aeruginosa (2.9% versus 10%, p = 0.019) and Acinetobacter spp . (1.9% versus 7.2%, p = 0.012) growths when compared with BAL samples. Conclusion The present study could identify a distinctive pattern of inflammatory cell distribution in sputum and BAL samples of AECOPD patients. The most commonly isolated organisms were Klebsiella pneumoniae and Strept. pneumoniae .

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confidence: 62%

“…Prevention of AECOPD by modifying the lower respiratory tract using different medications was suggested. 41 …”

Section: Discussionmentioning

confidence: 99%

Bacterial Species and Inflammatory Cell Variability in Respiratory Tracts of Patients with Chronic Obstructive Pulmonary Disease Exacerbation: A Multicentric Study

Salama¹,

Moazen²,

Elsawy³

et al. 2023

IDR

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“…Compared to systemic administration, pulmonary administration has been shown to be more acceptable to patients and reduces drug clearance in the liver and kidneys. 4,53 Moreover, delivering drugs directly to the lungs can also protect RNAi drugs from degradation by RNA enzymes in the blood. 54 Remarkably, senescent cells, which are currently believed to be involved in disease pathogenesis, may have unknown benecial functions.…”

Section: Sifoxo4-nt Selectively Eliminates Cse-induced Senescent Hfl-...mentioning

confidence: 99%

DNA nanoparticles targeting FOXO4 selectively eliminate cigarette smoke-induced senescent lung fibroblasts

Han,

Wu,

et al. 2023

Nanoscale Adv.

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“…Chronic obstructive pulmonary disease (COPD) is a progressive lung disease that represents a significant global burden [ 1 – 3 ], with smoking and ambient particulate matter being the main risk factors [ 2 , 4 , 5 ]. Persistent airway inflammation is the main pathology of COPD, which leads to airway remodeling and small airway obstruction [ 6 ], presenting as an increase in the overall thickness of the airway wall [ 7 ].…”

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confidence: 99%

Astaxanthin attenuates cigarette smoke-induced small airway remodeling via the AKT1 signaling pathway

Ding,

Yan,

Wang

et al. 2024

Respir Res

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Background Astaxanthin (AXT) is a keto-carotenoid with a variety of biological functions, including antioxidant and antifibrotic effects. Small airway remodeling is the main pathology of chronic obstructive pulmonary disease (COPD) and is caused by epithelial-to-mesenchymal transition (EMT) and fibroblast differentiation and proliferation. Effective therapies are still lacking. This study aimed to investigate the role of AXT in small airway remodeling in COPD and its underlying mechanisms. Methods First, the model of COPD mice was established by cigarette smoke (CS) exposure combined with intraperitoneal injection of cigarette smoke extract (CSE). The effects of AXT on the morphology of CS combined with CSE -induced emphysema, EMT, and small airway remodeling by using Hematoxylin-eosin (H&E) staining, immunohistochemical staining, and western blot. In addition, in vitro experiments, the effects of AXT on CSE induced-EMT and fibroblast function were further explored. Next, to explore the specific mechanisms underlying the protective effects of AXT in COPD, potential targets of AXT in COPD were analyzed using network pharmacology. Finally, the possible mechanism was verified through molecular docking and in vitro experiments. Results AXT alleviated pulmonary emphysema, EMT, and small airway remodeling in a CS combined with CSE -induced mouse model. In addition, AXT inhibited the EMT process in airway cells and the differentiation and proliferation of fibroblasts. Mechanistically, AXT inhibited myofibroblast activation by directly binding to and suppressing the phosphorylation of AKT1. Therefore, our results show that AXT protects against small airway remodeling by inhibiting AKT1. Conclusions The present study identified and illustrated a new food function of AXT, indicating that AXT could be used in the therapy of COPD-induced small airway remodeling.

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Inhaled antibiotics and airway bacterial decolonization for patients with chronic obstructive pulmonary disease: The rationale and future

Abstract: The research on the application of antibiotics in COPD was first started in the 1950s. Staykova et al. analyzed nine of these

Cited by 11 publications

References 30 publications

Bacterial Species and Inflammatory Cell Variability in Respiratory Tracts of Patients with Chronic Obstructive Pulmonary Disease Exacerbation: A Multicentric Study

Bacterial Species and Inflammatory Cell Variability in Respiratory Tracts of Patients with Chronic Obstructive Pulmonary Disease Exacerbation: A Multicentric Study

DNA nanoparticles targeting FOXO4 selectively eliminate cigarette smoke-induced senescent lung fibroblasts

Astaxanthin attenuates cigarette smoke-induced small airway remodeling via the AKT1 signaling pathway

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